Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Molecular cloning (2nd Ed)

1989 • 1,191 citations

Structure of a serpin–protease complex shows inhibition by deformation

2000 • 1,054 citations

Expression of baculovirus P35 prevents cell death in Drosophila

1994 • 1,037 citations

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

1991 • 810 citations

Improving biosensor analysis

1999 • 753 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

Caspase inhibitors

1999 • 372 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

Structural basis of the endoproteinase–protein inhibitor interaction

2000 • 283 citations

CLAMP©: a biosensor kinetic data analysis program

1998 • 217 citations

Interaction of the Baculovirus Anti-apoptotic Protein p35 with Caspases. Specificity, Kinetics, and Characterization of the Caspase/p35 Complex

1998 • 212 citations

A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction

2000 • 185 citations

Catalytic properties of the caspases

1999 • 178 citations

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

1999 • 176 citations

Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease

1996 • 170 citations

Structural basis for serpin inhibitor activity

1995 • 157 citations

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

1999 • 146 citations

Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition

1999 • 107 citations

Targeted expression of baculovirus p35 caspase inhibitor in oligodendrocytes protects mice against autoimmune-mediated demyelination

2000 • 99 citations

Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.

1997 • 64 citations

REPLACE, a suite of computer programs for molecular-replacement calculations

1993 • 48 citations

Caspase Inhibition by Baculovirus P35 Requires Interaction between the Reactive Site Loop and the β-Sheet Core

1999 • 34 citations

Evidence for an Ester Bond between Thrombin and Heparin Cofactor

1976 • 26 citations