3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

1990 • 2,192 citations

Regression of Coronary Atherosclerosis During Treatment of Familial Hypercholesterolemia With Combined Drug Regimens

1990 • 793 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

1983 • 548 citations

Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia

1991 • 489 citations

Myopathy and Rhabdomyolysis Associated With Lovastatin-Gemfibrozil Combination Therapy

1990 • 422 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Discovery, biochemistry and biology of lovastatin

1988 • 348 citations

Efficacy and long-term adverse effect pattern of lovastatin

1988 • 338 citations

HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.

1989 • 336 citations

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.

1986 • 331 citations

Influence of Pravastatin, a Specific Inhibitor of HMG-CoA Reductase, on Hepatic Metabolism of Cholesterol

1990 • 276 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

Simvastatin

1990 • 219 citations

Lovastatin (Mevinolin) in the Treatment of Heterozygous Familial Hypercholesterolemia

1987 • 215 citations

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.

1985 • 210 citations

Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production.

1990 • 210 citations

Hypocholesterolemic effects of mevinolin in patients with heterozygous familial hypercholesterolemia.

1984 • 176 citations

Therapeutic response to lovasatain (Mevinolin) in nonfamilial hypercholesterolemia - A Multicenter study

1986 • 175 citations

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

1989 • 172 citations

Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens

1990 • 170 citations

Lovastatin for Lowering Cholesterol Levels in Non-Insulin-Dependent Diabetes Mellitus

1988 • 158 citations

EFFECTS OF SYNVINOLIN (MK-733) ON PLASMA LIPIDS IN FAMILIAL HYPERCHOLESTEROLAEMIA

1986 • 157 citations

Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme a reductase inhibitors

1989 • 136 citations

Lovastatin

1988 • 134 citations

Concentrations of Pravastatin and Lovastatin in Cerebrospinal Fluid in Healthy Subjects

1991 • 126 citations

Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.

1984 • 124 citations

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B‐containing lipoproteins

1990 • 118 citations

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

1983 • 117 citations

Pravastatin

1991 • 117 citations

Rhabdomyolysis and Acute Renal Failure Induced by Combination Lovastatin and Gemfibrozil Therapy

1990 • 94 citations

HEPATICOJEJUNOSTOMY WITH TRANSHEPATIC INTUBATION

1964 • 92 citations

Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins

1992 • 91 citations

The influence of apolipoprotein E phenotype on the response to lovastatin therapy in patients with heterozygous familial hypercholesterolemia

1990 • 88 citations

Lovastatin therapy in familial dysbetalipoproteinemia: Effects on kinetics of apolipoprotein B

1988 • 83 citations

Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

1988 • 82 citations

Simvastatin (MK-733): a potent cholesterol synthesis inhibitor in heterozygous familial hypercholesterolaemia

1988 • 79 citations

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.

1988 • 73 citations

Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy

1990 • 70 citations

Comparison between lovastatin and gemfibrozil in the treatment of primary hypercholesterolemia: The finnish multicenter study

1988 • 68 citations

Once‐daily pravastatin in patients with primary hypercholesterolemia: A dose‐response study

1991 • 66 citations

LOVASTATIN TREATMENT OF HYPERCHOLESTEROLEMIA IN RENAL TRANSPLANT RECIPIENTS

1990 • 55 citations

Comparison of Lovastatin and Gemfibrozil in Normolipidemic Patients With Hypoalphalipoproteinemia

1989 • 55 citations

The hypolipidemic effects of lovastatin and clofibrate alone and in combination in patients with type III hyperlipoproteinemia

1990 • 54 citations

Lovastatin in the Treatment of Multifactorial Hyperlipidemia Associated With Proteinuria

1989 • 54 citations

Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias

1992 • 54 citations

Lovastatin. Warfarin interaction

1990 • 54 citations

Extended clinical safety profile of lovastatin

1990 • 53 citations

Primary Hypertriglyceridemia With Borderline High Cholesterol and Elevated Apolipoprotein B Concentrations

1990 • 53 citations

Comparative efficacy of once versus twice daily mevinolin in the therapy of familial hypercholesterolemia

1986 • 52 citations

Lack of effect of lovastatin therapy on the parameters of whole-body cholesterol metabolism.

1990 • 49 citations

Comparison of low-dose simvastatin and gemfibrozil in the treatment of elevated plasma cholesterol

1989 • 48 citations

Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia

1989 • 45 citations

Treatment of familial hypercholesterolaemia: a controlled trial of the effects of pravastatin or cholestyramine therapy on lipoprotein and apolipoprotein levels

1990 • 44 citations

Modulation of chylomicron remnant metabolism by an hepatic hydroxymethylglutaryl coenzyme A reductase inhibitor

1990 • 42 citations

The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia

1990 • 39 citations

Cholesterol homeostasis in mononuclear leukocytes from patients with familial hypercholesterolemia treated with lovastatin.

1989 • 33 citations

Comparative hypolipidemic effects of lovastatin and simvastatin in patients with heterozygous familial hypercholesterolemia

1992 • 31 citations

Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II

1986 • 29 citations

Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100

1992 • 29 citations

Regression of Tendon Xanthomas in Patients With Familial Hypercholesterolemia Treated With Lovastatin

1990 • 24 citations

The Influence of Simvastatin on Adrenal Corticosteroid Production and Urinary Mevalonate during Adrenocorticotropin Stimulation in Patients with Heterozygous Familial Hypercholesterolemia*

1991 • 17 citations

Long-term maintenance of therapeutic response to lovastatin in patients with familial and non-familial hypercholesterolemia: a 3-year follow-up

1990 • 16 citations

Comparison of lovastatin and gemfibrozil in normolipidemic patients with hypoalphalipoproteinemia

1989 • 10 citations

Congenital abnormalities

1993 • 7 citations

[Treatment of familial hypercholesterolemia].

1987 • 4 citations

Use and Abuse of Lovastatin

1991 • 1 citations