Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Rates of sterol synthesis and uptake in the major organs of the rat in vivo.

1981 • 212 citations

Measurement of rates of cholesterol synthesis using tritiated water

1984 • 204 citations

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

1991 • 181 citations

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

1989 • 172 citations

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

1990 • 171 citations

Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates.

1979 • 160 citations

The physiological disposition of lovastatin.

1989 • 123 citations

Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens.

1989 • 105 citations

Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors.

1990 • 74 citations

Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

1990 • 73 citations

Physiological Disposition of Hmg-Coa-Reductase Inhibitors

1990 • 68 citations

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase

1991 • 59 citations

Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase

1990 • 56 citations

Dissociation of hepatic cholesterol synthesis from hepatic low-density lipoprotein uptake and biliary cholesterol saturation in female and male hamsters of different ages

1983 • 46 citations

A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase

1989 • 32 citations

Inhibition of cholesterol synthesis by lovastatin tested on six human cell typesin vitro

1990 • 17 citations

Efficacy, tissue distribution and biliary excretion of methyl (3R∗,5S∗)-(E)-3,5-dihydroxy-9,9-diphenyl-6, 8-nonadienoate (CP-83101), A hepatoselective inhibitor of HMG-CoA reductase activity in the rat

1990 • 12 citations

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