Stimulation of Peroxisome Proliferator-Activated Receptors α and γ Blocks HIV-1 Replication and TNFα Production in Acutely Infected Primary Blood Cells, Chronically Infected U1 Cells, and Alveolar Macrophages From HIV-Infected Subjects

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

1998 • 2,421 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: acohort study

1999 • 1,549 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

1999 • 744 citations

The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy

2000 • 582 citations

Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site

1997 • 544 citations

Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients

1998 • 542 citations

Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors

1999 • 533 citations

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

1997 • 524 citations

Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design

1994 • 521 citations

Effects of Protease Inhibitors on Hyperglycemia, Hyperlipidemia, and Lipodystrophy

2000 • 465 citations

Clinical assessment of HIV-associated lipodystrophy in an ambulatory population

2001 • 429 citations

Fat distribution evaluated by computed tomography and metabolic abnormalities in patients undergoing antiretroviral therapy: preliminary results of the LIPOCO* study

2000 • 366 citations

Reversion of metabolic abnormalities after switching from HIV-1 protease inhibitors to nevirapine

1999 • 336 citations

The HIV Protease Inhibitor Indinavir Impairs Sterol Regulatory Element-Binding Protein-1 Intranuclear Localization, Inhibits Preadipocyte Differentiation, and Induces Insulin Resistance

2001 • 318 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Efficacy and Safety of Troglitazone in the Treatment of Lipodystrophy Syndromes

2000 • 301 citations

Metformin in the Treatment of HIV Lipodystrophy Syndrome

2000 • 300 citations

Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes

1998 • 287 citations

Effect of troglitazone on body fat distribution in type 2 diabetic patients.

1999 • 282 citations

Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy

1999 • 242 citations

ERK MAP Kinase Links Cytokine Signals to Activation of Latent HIV-1 Infection by Stimulating a Cooperative Interaction of AP-1 and NF-κB

1999 • 202 citations

Fasting Hyperinsulinemia and Changes in Regional Body Composition in Human Immunodeficiency Virus-Infected Women¹

1999 • 193 citations

Antiretroviral Treatment Simplification With Nevirapine in Protease Inhibitor–Experienced Patients With HIV-Associated Lipodystrophy

2001 • 173 citations

Diabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART).

1999 • 173 citations

HIV protease inhibitors block adipogenesis and increase lipolysis in vitro

2000 • 163 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 161 citations

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase

1998 • 156 citations

Interactions between Subunits of the Human Epithelial Sodium Channel

1997 • 140 citations

Fasting Hyperinsulinemia and Changes in Regional Body Composition in Human Immunodeficiency Virus-Infected Women

1999 • 135 citations

Normalization of Plasma Lipid Peroxides, Monocyte Adhesion, and Tumor Necrosis Factor-α Production in NIDDM Patients After Gliclazide Treatment

1998 • 124 citations

Regulation of TNF Expression by Multiple Mitogen-Activated Protein Kinase Pathways

2000 • 123 citations

Fasting Hyperinsulinemia in Human Immunodeficiency Virus-Infected Men: Relationship to Body Composition, Gonadal Function, and Protease Inhibitor Use1

2000 • 118 citations

The HIV Protease Inhibitor Nelfinavir Induces Insulin Resistance and Increases Basal Lipolysis in 3T3-L1 Adipocytes

2001 • 103 citations

The HIV Protease Inhibitor Indinavir Decreases Insulin- and Contraction-Stimulated Glucose Transport in Skeletal Muscle

2001 • 93 citations

HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer

2000 • 81 citations

Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.

1996 • 74 citations

Fasting Hyperinsulinemia in Human Immunodeficiency Virus-Infected Men: Relationship to Body Composition, Gonadal Function, and Protease Inhibitor Use

2000 • 67 citations

Antiretroviral Treatment Simplification With Nevirapine in Protease Inhibitor–Experienced Patients With HIV-Associated Lipodystrophy

2001 • 64 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 64 citations

Phosphorylation of Tumor Necrosis Factor Receptor CD120a (p55) by p42 Induces Changes in Its Subcellular Localization

1999 • 60 citations

Altered Fat Distribution in HIV-Positive Men on Nucleoside Analog Reverse Transcriptase Inhibitor Therapy

2001 • 47 citations

Tumor necrosis factor-? initiated signal transduction in 3T3-L1 adipocytes

1999 • 47 citations

Peroxisome Proliferator-activated Receptor γ Agonists Inhibit HIV-1 Replication in Macrophages by Transcriptional and Post-transcriptional Effects

2002 • 46 citations

The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors

1994 • 35 citations

Tumor necrosis factor-α mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes

1998 • 19 citations

Soluble Tumor Necrosis Factor Receptors Inhibit Phorbol Myristate Acetate and Cytokine-Induced HIV-1 Expression Chronically Infected U1 Cells

1996 • 7 citations