HIV protease inhibitors block adipogenesis and increase lipolysis in vitro

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

1998 • 9,382 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

1998 • 2,421 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.

1996 • 1,169 citations

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1998 • 1,109 citations

Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

1999 • 884 citations

HIV-Protease Inhibitors

1998 • 868 citations

Adverse effects of reverse transcriptase inhibitors

1998 • 853 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Mitochondrial toxicity of antiviral drugs

1995 • 760 citations

Visceral abdominal-fat accumulation associated with use of indinavir

1998 • 717 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy

1999 • 607 citations

“Buffalo hump” in men with HIV-1 infection

1998 • 581 citations

Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients

1998 • 542 citations

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.

1997 • 524 citations

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1994 • 367 citations

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Enhancement of adipocyte differentiation by an insulin-sensitizing agent.

1992 • 274 citations

The Complement Abnormalities of Lipodystrophy

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Multiple-informant ranking of the disabling effects of different health conditions in 14 countries

1999 • 223 citations

The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis.

1993 • 218 citations

Multiple-dose pharmacokinetics of ritonavir in human immunodeficiency virus-infected subjects

1997 • 185 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 161 citations

Development of a Scintillation Proximity Assay for Peroxisome Proliferator-Activated Receptor γ Ligand Binding Domain

1998 • 112 citations

Effects of troglitazone and metformin on glucose and lipid metabolism

1997 • 110 citations

Stavudine

1996 • 102 citations

Regulation of Adipose Cell Development In Utero

1998 • 100 citations

Disposition of indinavir, a potent HIV-1 protease inhibitor, after an oral dose in humans.

1996 • 93 citations

Nelfinavir

1998 • 86 citations

The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

1999 • 86 citations

Nelfinavir Mesylate: A Protease Inhibitor

1999 • 85 citations

The Effect of Progesterone and of Insulin Administration on Regional Adipose Tissue Cellularity in the Rat

1976 • 83 citations

HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer

2000 • 81 citations

Regression of white adipose tissue in diabetic rats

1989 • 77 citations

HIV Protease Inhibitors: Advances in Therapy and Adverse Reactions, Including Metabolic Complications

1999 • 66 citations

Stimulation of vitamin A1 acid signaling by the HIV protease inhibitor indinavir

2000 • 65 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 64 citations

Recent Studies of the 3T3-L1 Adipocyte-Like Cell Line

1979 • 64 citations

Detection and quantification of the control proteins of the alternative pathway of complement in 3T3‐L1 adipocytes

1997 • 64 citations

Thiazolidinediones inhibit alkaline phosphatase activity while increasing expression of uncoupling protein, deiodinase, and increasing mitochondrial mass in C3H10T1/2 cells

1997 • 53 citations

Partial lipodystrophy, mesangiocapillary glomerulonephritis, and complement dysregulation

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Disorders of the complement system in lipodystrophy

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Longer‐Term Immunologic Effects and Side Effects of Successful Antiretroviral Therapy

1999 • 34 citations

Protease inhibitors and nucleoside analogue reverse transcriptase inhibitors interact to cause subcutaneous fat wasting in patients with HIV infection

1999 • 19 citations

Therapeutic approaches to Type 2 diabetes mellitus

1999 • 8 citations

β‐Adrenoceptor Assays

1998 • 2 citations