Circulating and tissue angiotensin systems.

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Organization of Angiotensin II Immunoreactive Cells and Fibers in the Rat Central Nervous System

1985 • 652 citations

The renin-angiotensin-aldosterone system

1978 • 606 citations

Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat.

1986 • 484 citations

Neovascularization produced by angiotensin II.

1985 • 392 citations

Release of a Prostaglandin E-Like Substance from Canine Kidney by Bradykinin

1972 • 354 citations

Captopril-induced Changes in Prostaglandin Production

1980 • 340 citations

Angiotensin Synthesis in the Brain and Increased Turnover in Hypertensive Rats

1983 • 325 citations

Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases.

1982 • 298 citations

Accentuated Vascular and Endocrine Response to Sq 20881 in Hypertension

1977 • 270 citations

Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity.

1986 • 256 citations

Prorenin and Other Large Molecular Weight Forms of Renin*

1980 • 229 citations

Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics

1984 • 216 citations

Tubular transport responses to angiotensin

1985 • 212 citations

Role of the intrarenal renin-angiotensin system in the control of renal function.

1981 • 195 citations

Regulation by angiotensin II of its receptors in resistance blood vessels

1980 • 194 citations

The Brain Renin-Angiotensin System

1984 • 193 citations

LONG-TERM EFFECTS OF CAPTOPRIL (SQ14 225) ON BLOOD-PRESSURE AND HORMONE LEVELS IN ESSENTIAL HYPERTENSION

1979 • 191 citations

Evidence for a Putatively New Angiotensin II-generating Enzyme in the Vascular Wall

1984 • 178 citations

Renin synthesis by canine aortic smooth muscle cells in culture

1982 • 175 citations

Production of Renin by in vitro Cultures of Human Chorion and Uterine Muscle

1968 • 174 citations

Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes

1978 • 152 citations

Tissue and gene specificity of mouse renin expression.

1984 • 138 citations

Blood vessel-hormone interactions: angiotensin, bradykinin, and prostaglandins

1977 • 134 citations

Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.

1984 • 123 citations

Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins.

1981 • 122 citations

Angiotensin II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney.

1981 • 120 citations

Renin expression by vascular endothelial cells in culture.

1985 • 118 citations

Arterial wall uptake of renal renin and blood pressure control.

1983 • 111 citations

ANGIOTENSIN II BLOOD-LEVELS IN HUMAN HYPERTENSION

1971 • 106 citations

Beta-adrenoceptor-mediated release of angiotensin II from mesenteric arteries

1986 • 106 citations

Identification of a human neutrophil angiotension II-generating protease as cathepsin G.

1982 • 105 citations

Converting enzyme inhibitor and saralasin infusion in rats. Evidence for an additional vasodepressor property of converting enzyme inhibitor.

1978 • 103 citations

Renin and Angiotensin: the Complete System Within the Neuroblastoma × Glioma Cell

1981 • 102 citations

Immunocytochemical localization of angiotensinogen in rat liver and kidney

1983 • 100 citations

Human Chorionic Cells in Primary Culture: A Model for Renin Biosynthesis

1982 • 99 citations

Comparison of fast and slow pressor effects of angiotensin II in the conscious rat

1981 • 97 citations

Circulating angiotensin II and adrenal receptors after nephrectomy

1981 • 96 citations

Angiotensin II and its heptapeptide (2-8), hexapeptide (3-8), and pentapeptide (4-8) metabolites in arterial and venous blood of man.

1976 • 95 citations

The intrarenal renin-angiotensin-system

1982 • 95 citations

Control of Enzymatically Inactive Renin in man under Various Pathological Conditions: Implications for the Interpretation of Renin Measurements in Peripheral and Renal Venous Plasma

1978 • 94 citations

MEASUREMENT OF ANGIOTENSIN II IN BLOOD

1967 • 94 citations

Effects of a specific and long-acting renin inhibitor in the marmoset.

1985 • 94 citations

Vasodepressor Property of the Converting Enzyme Inhibitor Captopril (SQ 14 225): The Role of Factors other than Renin-Angiotensin Blockade in the Rat

1980 • 87 citations

Plasma prorenin and renin in anephric patients.

1977 • 87 citations

Evidence for intracellular formation of angiotensins: Coexistence of renin and angiotensin-converting enzyme in Leydig cells of rat testis

1984 • 86 citations

Arterial Wall or Plasma Renin in Hypertension?

1979 • 86 citations

Role of angiotensinogen in blood pressure homeostasis.

1982 • 79 citations

IMMUNOLOGIC IDENTIFICATION OF BOTH PLASMA AND HUMAN RENAL INACTIVE RENIN AS PRORENIN

1985 • 70 citations

Plasma prorenin and renin in anephric patients.

1977 • 69 citations

Measurement of Concentrations of Angiotensin I in Human Blood by Radioimmunoassay

1973 • 64 citations

The tissue Renin-Angiotensin Systems: Focus on Brain Angiotensin, Adrenal Gland and Arterial Wall

1983 • 64 citations

In vitro biosynthesis of human renin and identification of plasma inactive renin as an activation intermediate.

1985 • 64 citations

Renal hemodynamics and renal kinins after angiotensin-converting enzyme inhibition

1981 • 61 citations

Tonin, angiotensin II system. A review.

1977 • 59 citations

A comparison of the substrate specificities of cathepsin D and pseudorenin.

1978 • 51 citations

Metabolism and blood levels of angiotensin II in normal subjects, renal disease, and essential hypertension.

1970 • 51 citations

Immunohistochemical evidence that angiotensins I and II are formed by intracellular mechanism in juxtaglomerular cells.

1982 • 51 citations

Time Course and Effect of Sodium Intake on Vascular and Hormonal Responses to Enalapril (MK 421) in Normal Subjects

1983 • 49 citations

Confirmation of direct angiotensin formation by kallikrein

1983 • 47 citations

Evidence from a dual action of converting enzyme inhibitor on blood pressure in normal man

1981 • 45 citations

Renin, renin substrate, and angiotensin I-converting enzyme in the lymph of rats

1971 • 45 citations

Renin substrate in granules from rat kidney cortex

1976 • 45 citations

Attenuation of pressor responses to norepinephrine and pitressin and potentiation of pressor response to angiotensin II by captopril in human subjects.

1982 • 45 citations

Detection of renin mRNA in mouse testis by hybridization with renin cDNA probe

1984 • 42 citations

Clinical aspects of essential hypertension

1983 • 38 citations

Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism.

1981 • 38 citations

Renal vasodilation by converting enzyme inhibition. Role of renal prostaglandins.

1983 • 37 citations

Isolation and identification of a pepsitensin

1965 • 37 citations

Absence of renin-like activity in rat aorta and microvessels.

1983 • 37 citations

A Comparison of Minoxidil and Hydralazine in Non-azotemic Hypertensives

1983 • 36 citations

Arterial wall renin.

1983 • 36 citations

Converting enzyme inhibition during chronic angiotensin II infusion in rats. Evidence against a nonangiotensin mechanism.

1981 • 36 citations

Renin in anephric man

1972 • 33 citations

Prediction of sustained antihypertensive efficacy of chronic captopril therapy: Relationships to immediate blood pressure response and control plasma renin activity

1982 • 33 citations

Role of sympathetic nervous system activity in the blood pressure response to long-term captopril therapy in severely hypertensive patients

1982 • 32 citations

Differences in response to the peptidyldipeptide hydrolase inhibitors SQ 20,881 and SQ 14,225 in normal-renin essential hypertension.

1980 • 31 citations

The Effect of Captopril on Blood Pressure and Angiotensins I, II and III in Sodium-Depleted Dogs: Problems Associated with the Measurement of Angiotensin II after Inhibition of Converting Enzyme

1980 • 31 citations

Single-Dose Captopril Administration in DOCA/Salt Rats: Reduction of Hypotensive Effect by Indomethacin

1980 • 30 citations

Does captopril lower blood pressure in anephric patients?

1979 • 28 citations

Peptide Inhibitors of Renin

1983 • 28 citations

Renin in the Brain and Neuroblastoma Cells: An Endogenous and Intracellular System

1982 • 27 citations

Chemical identity of tryptensin with angiotensin

1980 • 27 citations

Biochemical and Immunological Characterization of Ectopic Tumoral Renin

1982 • 27 citations

Pharmacology of Converting Enzyme Inhibitors: New Aspects

1983 • 26 citations

Identification of Renin and Renin-like Enzymes in Rat Brain by a Renin-Specific Antibody

1980 • 21 citations

Abnormalities and Drug-Induced Alterations of Vasopressin in Human Hypertension

1981 • 18 citations

Generation of angiotensins in cultured pheochromocytoma cells

1984 • 18 citations

FAILURE OF ASPIRIN TO MODIFY THE HYPOTENSIVE ACTION OF CAPTOPRIL IN SPONTANEOUSLY HYPERTENSIVE RATS

1981 • 14 citations

Angiotensin-producing Enzyme I of Serum: Formation by Immunization with Renin

1984 • 11 citations

Biochemical and Immunological Properties of Dog Brain Isorenin*

1984 • 11 citations

Evidence for existence of angiotensins I and II in mature renin granules from rat kidney cortex

1985 • 10 citations

Renal Prostaglandin E in the Hypotensive Mechanism of MK-421 in Conscious Rats

1984 • 8 citations

Decreased uterine bradykinin receptors during captopril infusion in rats

1982 • 6 citations

Immunochemical Differences between Angiotensin I-Forming Enzymes in Man

1980 • 6 citations

Angiotensin-producing serum enzyme II. Formation by inhibitor removal and proenzyme activation.

1985 • 5 citations