The Renin-Angiotensin System and Vascular Hypertrophy

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke

1972 • 1,098 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension

1991 • 734 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.

1989 • 632 citations

Protein kinase C in the regulation of smooth muscle contraction

1987 • 543 citations

Expression of AT2 receptors in the developing rat fetus.

1991 • 537 citations

Remodeling of cerebral arterioles in chronic hypertension.

1989 • 493 citations

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

1993 • 470 citations

Cardiac Hypertrophy in Spontaneously Hypertensive Rats

1974 • 458 citations

Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.

1993 • 409 citations

Molecular biology of the renin-angiotensin system.

1993 • 403 citations

Angiotensin II Induces c-fos mRNA in Aortic Smooth Muscle

1989 • 401 citations

Release of a Prostaglandin E-Like Substance from Canine Kidney by Bradykinin

1972 • 354 citations

Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain

1991 • 342 citations

"Structural factor" in primary and secondary hypertension.

1990 • 337 citations

Levels of angiotensin and molecular biology of the tissue renin angiotensin systems

1993 • 333 citations

Effect of Antihypertensive Treatment on Small Arteries of Patients With Previously Untreated Essential Hypertension

1995 • 304 citations

Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells

1991 • 288 citations

Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells.

1993 • 251 citations

Slow Pressor Mechanisms in Hypertension: A Role for Hypertrophy of Resistance Vessels?

1986 • 247 citations

Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats.

1990 • 234 citations

Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells

1991 • 230 citations

Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats.

1987 • 229 citations

Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.

1992 • 221 citations

Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension.

1988 • 221 citations

Effects of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension.

1988 • 220 citations

Proposed Update of Angiotensin Receptor Nomenclature

1995 • 220 citations

Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.

1994 • 213 citations

Activation of human peripheral monocytes by angiotensin II

1994 • 210 citations

Angiotensin II induces c-fos expression in smooth muscle via transcriptional control.

1989 • 206 citations

Changes in expression of angiotensin receptor subtypes in the rat aorta during development

1991 • 203 citations

Protein kinase C in transmembrane signalling

1990 • 194 citations

Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats.

1986 • 192 citations

Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange.

1989 • 190 citations

Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta.

1992 • 188 citations

Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector.

1985 • 185 citations

Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development.

1991 • 184 citations

Angiotensin II increases plasminogen activator inhibitor type 1 and tissue-type plasminogen activator messenger RNA in cultured rat aortic smooth muscle cells.

1994 • 177 citations

Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats

1990 • 174 citations

Frontiers in Hypertension Research.

1981 • 172 citations

Histology of subcutaneous small arteries from patients with essential hypertension.

1993 • 171 citations

Development of blood pressure in spontaneously hypertensive rats after withdrawal of long-term treatment related to vascular structure

1989 • 163 citations

Molecular biology of the renin-angiotensin system

1988 • 156 citations

An evaluation of large arteries compliance in man

1979 • 152 citations

Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II.

1993 • 152 citations

Different distribution of two types of angiotensin II-generating enzymes in the aortic wall

1987 • 151 citations

Systolic hypertension: Hemodynamic mechanism and choice of antihypertensive treatment

1979 • 148 citations

Angiotensin II induces expression of the - gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells

1988 • 146 citations

Induction of the proto-oncogene c-jun by angiotensin II.

1990 • 143 citations

Prognostic factors in medullary thyroid carcinoma: evaluation of 741 patients from the German Medullary Thyroid Carcinoma Register

1993 • 141 citations

Chymase-dependent angiotensin II forming system in humans

1996 • 141 citations

Progressive improvement in the structure of resistance arteries of hypertensive patients after 2 years of treatment with an angiotensin i-converting enzyme inhibitor comparison with effects of a ?-locker

1995 • 137 citations

Renin in Rats with Spontaneous Hypertension

1972 • 132 citations

Extra-renal transcription of the renin genes in multiple tissues of mice and rats.

1989 • 127 citations

Molecular biology of angiotensin II receptors: an overview.

1994 • 123 citations

Prevention of hypertension and vascular changes by captopril treatment.

1991 • 113 citations

Angiotensin II Receptor Antagonist Losartan Has Persistent Effects on Blood Pressure in the Young Spontaneously Hypertensive Rat: Lack of Relation to Vascular Structure

1992 • 112 citations

The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G.

1982 • 107 citations

Heterogeneity of angiotensin synthetic pathways and receptor subtypes: physiological and pharmacological implications.

1993 • 102 citations

Renin-angiotensin system in spontaneously hypertensive rats

1976 • 100 citations

Stimulation of cyclic GMP production in cultured endothelial cells of the pig by bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide

1990 • 96 citations

Vascular Renin-Angiotensin System and Vascular Protection

1993 • 87 citations

The influence of perindopril and the diuretic combination amiloride + hydrochlorothiazide on the vessel wall properties of large arteries in hypertensive patients

1995 • 84 citations

Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.

1991 • 84 citations

Impaired systemic arterial compliance in borderline hypertension

1984 • 83 citations

Role of transforming growth factor-beta 1 in the cellular growth response to angiotensin II.

1993 • 82 citations

Cellular hypertrophy in mesenteric resistance vessels from renal hypertensive rats.

1988 • 76 citations

Characterization of AT2 angiotensin II receptors in rat anterior cerebral arteries

1991 • 73 citations

Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector.

1985 • 70 citations

Prenatal and postnatal hydralazine treatment does not prevent renal vessel wall thickening in SHR despite the absence of hypertension.

1988 • 69 citations

Peripheral large arteries and the response to antihypertensive treatment.

1983 • 68 citations

Comparison of oral MK 421 and propranolol in mild to moderate essential hypertension and their effects on arterial and venous vessels of the forearm

1984 • 65 citations

Molecular biology of hypertension.

1991 • 62 citations

Angiotensin II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin II AT1 receptor

1992 • 62 citations

Post-synaptic Alpha-blockade and Brachial Artery Compliance in Essential Hypertension

1984 • 61 citations

Angiotensin II can regulate gene expression by the AP-1 binding sequence via a protein kinase C-dependent pathway

1990 • 60 citations

Contribution of Bradykinin to the Cardiovascular Effects of Ramipril

1993 • 60 citations

Contribution of Bradykinin to the Cardiovascular Effects of Ramipril

1993 • 56 citations

Effects of angiotensin and angiotensin blockade on coronary circulation and coronary reserve

1988 • 53 citations

Electrocardiographic and Echocardiographic Findings in Top Athletes, Athletic Students and Sedentary Controls

1993 • 52 citations

EXP3174, a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells

1993 • 52 citations

Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients.

1982 • 51 citations

Cardiac and aortic effects of angiotensin converting enzyme inhibitors.

1991 • 47 citations

Peptide Growth Factors Markedly Decrease the Ligand Binding of Angiotensin II Type 2 Receptor in Rat Cultured Vascular Smooth Muscle Cells

1993 • 47 citations

Changes in gene expression of the renin???angiotensin system in two-kidney, one clip hypertensive rats

1991 • 47 citations

Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats.

1993 • 45 citations

Angiotensin II stimulates phosphorylation of nuclear lamins via a protein kinase C-dependent mechanism in cultured vascular smooth muscle cells.

1990 • 44 citations

Effects of Acute and Chronic Angiotensin-Converting Enzyme Inhibition on Large Arteries in Human Hypertension

1985 • 42 citations

Effects of antihypertensive treatment on composition of cerebral arterioles.

1991 • 42 citations

Chronic angiotensin II type 1 receptor antagonism in genetic hypertension: effects on vascular structure and reactivity

1993 • 42 citations

The influence of antihypertensive therapy on the structural arteriolar changes in essential hypertension: different effects of enalapril and hydrochlorothiazide

1993 • 38 citations

Morphology and function of mesenteric resistance arteries in transgenic rats with low-renin hypertension

1992 • 37 citations

Central and peripheral indices of sympathetic activity after blood pressure lowering with enalapril (MK-421) or hydralazine in normotensive rats.

1984 • 37 citations

Hypertrophy and hyperplasia cause differing effects on vascular smooth muscle cell Na+/H+ exchange and intracellular pH.

1990 • 36 citations

The effect of acute and chronic nicardipine therapy on forearm arterial haemodynamics in essential hypertension.

1985 • 35 citations

Angiotensin II signal transduction pathways in the cardiovascular system

1994 • 33 citations

Arterial Compliance in Systolic Hypertension

1982 • 30 citations

Effects of an Angiotensin II Receptor Antagonist, CV-11974, on Angiotensin II-Induced Increases in Cytosolic Free Calcium Concentration, Hyperplasia, and Hypertrophy of Cultured Vascular Smooth Muscle Cells

1994 • 27 citations

Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension

1990 • 26 citations

Arterial effects of angiotensin converting enzyme inhibition in renovascular and spontaneously hypertensive rats.

1988 • 24 citations

Effects of angiotensins on cellular hypertrophy and c‐fos expression in cultured arterial smooth muscle cells

1992 • 23 citations

Increased proliferation fate and phosphoinositide turnover in cultured smooth muscle cells from spontaneously hypertensive rats.

1987 • 23 citations

Large Arteries in Hypertension

1984 • 20 citations

Role of Arterial Compliance in the Physiopharmacological Approach to Human Hypertension

1992 • 19 citations

Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury

1995 • 19 citations

Haemodynamic Basis of Early Modifications of the Large Arteries in Borderline Hypertension

1987 • 18 citations

The renin-angiotensin system: an overview of its intracellular function

1988 • 16 citations

Determinants of angiotensin II‐induced hypertrophy versus hyperplasia in vascular smooth muscle

1993 • 15 citations

Inhibition of the Angiotensin Converting Enzyme by Perindoprilat and Release of Nitric Oxide

1995 • 15 citations

The role of antihypertensive drugs in counteracting adverse influence on large arteries

1987 • 14 citations

REMODELLING OF THE VASCULAR SYSTEM IN RESPONSE TO HYPERTENSION AND DRUG THERAPY

1992 • 14 citations

Molecular Biology of the Vascular Renin-Angiotensin System

1991 • 13 citations

Haemodynamic effects of pindolol in essential hypertension with special reference to resistance vessels in the forearm during maximal vasodilatation.

1985 • 13 citations

Long-term antihypertensive treatment may induce normalization of left ventricular mass before complete regression of vascular structural changes

1988 • 12 citations

Losartan inhibits the angiotensin II-induced stimulation of the phosphoinositide signalling system in vascular smooth muscle cells

1992 • 11 citations

Characterization of angiotensin converting enzyme in isolated cerebral microvessels from spontaneously hypertensive and normotensive rats

1992 • 11 citations

Effects of hydralazine on blood pressure, pressor mechanisms, and cardiac hypertrophy in two-kidney, one-clip hypertensive rats

1986 • 11 citations

The renin-angiotensin system and extracellular matrix

1993 • 11 citations

Hypertension-Induced Vascular Fibrosis and its Reversal by Antihypertensive Drugs

1981 • 10 citations

Role of Arterial Compliance in the Physiopharmacological Approach to Human Hypertension

1992 • 9 citations

MESENTERIC RESISTANCE AND BRAIN MICROVASCULAR ANGIOTENSIN‐CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT

1992 • 8 citations

Control of vascular structure.

1993 • 8 citations

The Renin-Angiotensin System and Arterial Wall Behavior

1993 • 8 citations

The efficacy of a transdermal formulation of clonidine in mild to moderate hypertension and its effects on the arterial and venous vasculature of the forearm

1987 • 6 citations

Vascular Protection with Cilazapril in Hypertension

1992 • 6 citations

THE EFFECT OF HYPERTENSION AND ACE INHIBITION ON ARTERIAL STRUCTURE AND COMPLIANCE

1992 • 4 citations

Vascular wall thickness in hypertension

1993 • 4 citations

Comparative haemodynamic effects of ketanserin and ritanserin in the proximal and distal upper limb circulations of hypertensive patients

1989 • 3 citations

Plaque Hypertension Lipid-Lowering Italian Study (PHYLLIS)

1993 • 3 citations

Autacoide und ihre Rolle in der Pathogenese der Husteninduktion durch Angiotensin-Konversionsenzym Hemmer

1993 • 1 citations