The Peroxisome Proliferator‐activated Receptors: Ligands and Activators^a

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

1992 • 454 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa

1994 • 380 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Studies on Antidiabetic Agents. X. Synthesis and Biological Activities of Pioglitazone and Related Compounds.

1991 • 284 citations

Enhancement of adipocyte differentiation by an insulin-sensitizing agent.

1992 • 274 citations

PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene

1993 • 265 citations

[[.omega.-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents

1994 • 259 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

1992 • 204 citations

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1995 • 185 citations

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

1994 • 174 citations

Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members

1993 • 154 citations

Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

1994 • 135 citations

The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor

1993 • 119 citations

Receptor-mediated mechanisms of peroxisome proliferators

1992 • 114 citations

Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells

1993 • 113 citations

Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones.

1990 • 81 citations

Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene

1993 • 78 citations

Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene.

1994 • 74 citations

Pathophysiology of peroxisomal beta-oxidation.

1989 • 62 citations

Peroxisome Proliferator-Activated Receptor (PPAR): Structure, Mechanisms of Activation and Diverse Functions.

1993 • 62 citations

Fatty Acid Activation of the Peroxisome Proliferator Activated Receptor, a Member of the Nuclear Receptor Gene Superfamily ,

1994 • 55 citations

Peroxisome proliferators: Paradigms and prospects

1993 • 38 citations

Peroxisome proliferators, a unique set of drug-metabolizing enzyme inducers: commentary on a symposium.

1992 • 38 citations

Coordinate induction of hepatic fatty acyl-CoA oxidase and P4504A1 in rat after activation of the peroxisome proliferator-activated receptor (PPAR) by sulphur-substituted fatty acid analogues

1994 • 15 citations