Possible mechanisms involved in tumor radiosensitization following nicotinamide administration

Oxygen in Human Tumors: Correlations between Methods of Measurement and Response to Therapy: Summary of a Workshop Held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland

1993 • 298 citations

Poly(ADP-ribose) and ADP-ribosylation of proteins

1976 • 283 citations

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

1989 • 266 citations

The Enhancement of Cytotoxicity of N‐Methyl‐N‐nitrosourea and of y‐Radiation by Inhibitors of Poly(ADP‐ribose) Polymerase

1980 • 196 citations

Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats.

1987 • 183 citations

A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments

1991 • 148 citations

Effect of Nicotinamide on the Microregional Heterogeneity of Oxygen Delivery Within a Murine Tumor

1990 • 144 citations

Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.

1989 • 124 citations

Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo

1991 • 112 citations

Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells.

1990 • 106 citations

Radiosensitization by Nicotinamide in Vivo: A Greater Enhancement of Tumor Damage Compared to That of Normal Tissues

1987 • 106 citations

Tumor Radiosensitization by Nicotinamide: A Result of Improved Perfusion and Oxygenation

1989 • 99 citations

Effect of Injectable or Inhalational Anesthetics and of Neuroleptic, Neuroleptanalgesic, and Sedative Agents on Tumor Blood Flow

1988 • 77 citations

Mechanism of action of the selective tumor radiosensitizer nicotinamide

1988 • 73 citations

Inhibitors of poly(adenosine diphosphoribose) synthetase, examination of metabolic perturbations, and enhancement of radiation response in Chinese hamster cells.

1985 • 65 citations

Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time

1993 • 64 citations

The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo

1990 • 58 citations

The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.

1984 • 50 citations

Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors

1993 • 43 citations

The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide.

1992 • 38 citations

Biochemical and physiological changes induced by nicotinamide in a C3H mouse mammary carcinoma and CDF1 mice

1992 • 35 citations

Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia

1991 • 33 citations

Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs

1970 • 32 citations

The Oxygenation of Murine Tumor Isografts and Human Tumor Xenografts by Nicotinamide

1992 • 32 citations

The measurement of radiosensitizer-induced changes in mouse tumor metabolism by 31P magnetic resonance spectroscopy

1991 • 21 citations

Energy Status and Radiobiological Hypoxia at Specified Oxygen Concentrations

1993 • 20 citations

Carbogen and nicotinamide: expectations too high?

1992 • 15 citations

Effects of the radiosensitising agent nicotinamide on relative tissue perfusion and kidney function in C3H mice

1993 • 14 citations

Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay

1993 • 12 citations

Tumour Radiosensitization by Nicotinamide: Is It the Result of an Improvement in Tumour Oxygenation?

1994 • 7 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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