Presynaptic control of quantal size: kinetic mechanisms and implications for synaptic transmission and plasticity

Synaptic Activity and the Construction of Cortical Circuits

1996 • 3,004 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse

2001 • 1,218 citations

Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.

1997 • 984 citations

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

2000 • 861 citations

Identification and characterization of the vesicular GABA transporter

1997 • 860 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter

2000 • 792 citations

Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.

1993 • 729 citations

Postsynaptic Signaling and Plasticity Mechanisms

2002 • 713 citations

Heterogeneous Release Properties of Visualized Individual Hippocampal Synapses

1997 • 605 citations

Transmitter timecourse in the synaptic cleft: its role in central synaptic function

1996 • 599 citations

Quantal analysis of synaptic potentials in neurons of the central nervous system.

1990 • 578 citations

Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch‐clamp study.

1990 • 545 citations

Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices.

1990 • 467 citations

Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude

1997 • 453 citations

Calcium Dependence and Recovery Kinetics of Presynaptic Depression at the Climbing Fiber to Purkinje Cell Synapse

1998 • 417 citations

Real-time measurement of transmitter release from single synaptic vesicles

1995 • 404 citations

Immunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain

2002 • 391 citations

Hippocampal pyramidal cells excite inhibitory neurons through a single release site

1993 • 388 citations

Optimizing Synaptic Architecture and Efficiency for High-Frequency Transmission

2002 • 387 citations

Multivesicular Release at Climbing Fiber-Purkinje Cell Synapses

2001 • 372 citations

Efficacy of Thalamocortical and Intracortical Synaptic Connections

1999 • 368 citations

Immunocytochemical localization of candidates for vesicular glutamate transporters in the rat cerebral cortex

2001 • 364 citations

Variability of Neurotransmitter Concentration and Nonsaturation of Postsynaptic AMPA Receptors at Synapses in Hippocampal Cultures and Slices

1999 • 357 citations

Multivesicular release from excitatory synapses of cultured hippocampal neurons

1994 • 333 citations

Facilitation at single synapses probed with optical quantal analysis

2002 • 330 citations

Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated

1999 • 321 citations

Properties of synaptic transmission at single hippocampal synaptic boutons

1995 • 315 citations

Three-Dimensional Comparison of Ultrastructural Characteristics at Depressing and Facilitating Synapses onto Cerebellar Purkinje Cells

2001 • 305 citations

Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals

2002 • 295 citations

Locus of frequency‐dependent depression identified with multiple‐probability fluctuation analysis at rat climbing fibre‐Purkinje cell synapses

1998 • 290 citations

Non‐NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites.

1996 • 266 citations

Postfusional regulation of cleft glutamate concentration during LTP at ‘silent synapses’

2000 • 247 citations

Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse

2002 • 243 citations

A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation

2001 • 226 citations

Spillover of Glutamate onto Synaptic AMPA Receptors Enhances Fast Transmission at a Cerebellar Synapse

2002 • 223 citations

Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses

1999 • 220 citations

Nonsaturation of AMPA and NMDA receptors at hippocampal synapses

2000 • 219 citations

Quantal Release of Serotonin

2000 • 217 citations

Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones

2000 • 211 citations

Development of Vesicle Pools during Maturation of Hippocampal Synapses

2002 • 211 citations

Variation in GABA mini amplitude is the consequence of variation in transmitter concentration

1995 • 211 citations

Loose-patch recordings of single quanta at individual hippocampal synapses

1997 • 185 citations

Regulation of Quantal Size by Presynaptic Mechanisms

2000 • 183 citations

Intrinsic Quantal Variability Due to Stochastic Properties of Receptor-Transmitter Interactions

1992 • 181 citations

A Single Packet of Transmitter Does Not Saturate Postsynaptic Glutamate Receptors

2002 • 180 citations

Quantal Size and Variation Determined by Vesicle Size in Normal and MutantDrosophilaGlutamatergic Synapses

2002 • 174 citations

Expression of a Putative Vesicular Acetylcholine Transporter Facilitates Quantal Transmitter Packaging

1997 • 174 citations

Multivesicular Release at Single Functional Synaptic Sites in Cerebellar Stellate and Basket Cells

1998 • 170 citations

A Monte Carlo Model Reveals Independent Signaling at Central Glutamatergic Synapses

2002 • 169 citations

Estimation of Quantal Size and Number of Functional Active Zones at the Calyx of Held Synapse by Nonstationary EPSC Variance Analysis

2001 • 154 citations

Quantal currents at single‐site central synapses

2000 • 137 citations

Altered Presynaptic Vesicle Release and Cycling during mGluR-Dependent LTD

2002 • 133 citations

Quantal amplitude and quantal variance of strontium‐induced asynchronous EPSCs in rat dentate granule neurons

1999 • 130 citations

Separation of Presynaptic and Postsynaptic Contributions to Depression by Covariance Analysis of Successive EPSCs at the Calyx of Held Synapse

2002 • 124 citations

Interaction of Postsynaptic Receptor Saturation with Presynaptic Mechanisms Produces a Reliable Synapse

2002 • 120 citations

Presynaptic origin of paired‐pulse depression at climbing fibre‐Purkinje cell synapses in the rat cerebellum

1998 • 119 citations

Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus

2001 • 112 citations

Saturation of postsynaptic receptors at central synapses?

1996 • 109 citations

Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation

1995 • 106 citations

Novel expression mechanism for synaptic potentiation: Alignment of presynaptic release site and postsynaptic receptor

1997 • 98 citations

Spillover and synaptic cross talk mediated by glutamate and GABA in the mammalian brain

2000 • 91 citations

Development of the quantal properties of evoked and spontaneous synaptic currents at a brain synapse

1998 • 86 citations

Quantal components of the excitatory postsynaptic currents at a rat central auditory synapse

2001 • 71 citations

Relationship between presynaptic calcium transients and postsynaptic currents at single γ-aminobutyric acid (GABA)ergic boutons

1999 • 69 citations

Behaviour of NMDA and AMPA receptor‐mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging

1999 • 67 citations

The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study

1997 • 65 citations

Splitting the quantum: regulation of quantal release during vesicle fusion

2002 • 64 citations

The essence of excitation

2001 • 56 citations

Glutamate release during LTD at cerebellar climbing fiber–Purkinje cell synapses

2002 • 39 citations

Spillover of glutamate onto synaptic AMPA receptors enhances fast transmission at a cerebellar synapse (vol 35, pg 521, 2002)

2002 • 10 citations