Processing of the Precursors to Neurotensin and Other Bioactive Peptides by Cathepsin E

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

1979 • 1,758 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

The Structure and Function of the Aspartic Proteinases

1990 • 637 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

1987 • 335 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

Evolution in the structure and function of aspartic proteases

1987 • 298 citations

Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8A˚resolution

1990 • 263 citations

The processing of peptide precursors

1986 • 249 citations

The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences.

1988 • 216 citations

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

1992 • 207 citations

Cellular and molecular biology of neuropeptide processing and packaging

1989 • 203 citations

Precursors for peptide hormones share common secondary structures forming features at the proteolytic processing sites

1986 • 183 citations

Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor.

1987 • 181 citations

Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles.

1985 • 179 citations

A systematic series of synthetic chromophoric substrates for aspartic proteinases

1986 • 174 citations

Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins.

1981 • 122 citations

The aspartic proteases

1992 • 122 citations

Pure Renin. Isolation from hog kidney and characterization.

1977 • 121 citations

Acid Proteases: Structure, Function, and Biology

1977 • 116 citations

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites.

1992 • 116 citations

Proteases and the emerging role of protease inhibitors in prohormone processing

1994 • 104 citations

Human Gastric Cathepsin E

1989 • 100 citations

Exploration of subsite binding specificity of human cathepsin D through kinetics and rule‐based molecular modeling

1993 • 99 citations

An Immunocytochemical Study on Distinct Intracellular Localization of Cathepsin E and Cathepsin D in Human Gastric Cells and Various Rat Cells

1991 • 81 citations

The family of pro-hormone and pro-protein convertases

1993 • 78 citations

Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s).

1987 • 61 citations

Posttranslational Processing of the Neurotensin/Neuromedin‐N Precursor

1992 • 60 citations

Subcellular localization and targeting of cathepsin E.

1994 • 59 citations

Gastric procathepsin E and progastricsin from guinea pig. Purification, molecular cloning of cDNAs, and characterization of enzymatic properties, with special reference to procathepsin E.

1992 • 57 citations

Processing of a fusion protein by endoprotease in COS-1 cells for secretion of mature peptide by using a chimeric expression vector.

1993 • 46 citations

Cathepsin E from rat neutrophils: Its properties and possible relations to cathepsin D-like and cathepsin E-like acid proteinases

1987 • 45 citations

Structure and Function of the Aspartic Proteinases: "Genetics, Structures, And Mechanisms"

2012 • 45 citations

Rabbit procathepsin E and cathepsin E

1993 • 45 citations

Further studies on rat cathepsin E: Subcellular localization and existence of the active subunit form

1988 • 44 citations

The complete amino acid sequence of monkey pepsinogen A.

1986 • 39 citations

Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin

1991 • 37 citations

[8] Procathepsin E and cathepsin E

1995 • 37 citations

Substrate specificity and inhibitors of aspartic proteinases

1992 • 37 citations

In vitro processing of proopiomelanocortin by recombinant PC1 (SPC3).

1994 • 33 citations

The Anglerfish Somatostatin-28-Generating Propeptide Converting Enzyme Is an Aspartyl Protease*

1991 • 30 citations

Generation of xenopsin-related peptides during acid extraction of gastric tissues.

1985 • 26 citations

Fluorimetric assay of renin

1978 • 24 citations

IMPROVED PURIFICATION OF SLOW MOVING PROTEASE FROM HUMAN GASTRIC MUCOSA AND ITS ACTION ON THE B CHAIN OF OXIDIZED BOVINE INSULIN

1988 • 16 citations

Isolation and sequence of canine xenopsin and an extended fragment from its precursor

1990 • 12 citations

Potential Precursors to Neuromedin N in the Cat and Their Processing by Pepsin*

1987 • 12 citations

[35] Renin

1981 • 12 citations

Pepsin-mediated processing of synthetic precursor-like sequence yields neurotensin-like peptide

1992 • 8 citations

<b>CATHEPSIN D FROM JAPANESE MONKEY SKELETAL MUSCLE: AN EFFICIENT AND HIGH-YIELD PURIFICATION AND SOME PROPERTIES </b>

1991 • 2 citations