New strategies for enhancing the immunogenicity of tumors

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Vaccinia virus: a selectable eukaryotic cloning and expression vector.

1982 • 663 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

Immunotherapy of malignancy by in vivo gene transfer into tumors.

1993 • 320 citations

Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma

1993 • 314 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

Characterization of Naturally Occurring Minor Histocompatibility Peptides Including H-4 and H-Y

1990 • 215 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Melanoma cells and normal melanocytes share antigens recognized by HLA-A2-restricted cytotoxic T cell clones from melanoma patients.

1993 • 173 citations

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.

1991 • 126 citations

Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes.

1993 • 122 citations

Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld).

1987 • 57 citations

Order and chaos up in the air

1990 • 5 citations