Cellular Suicide Therapy of Malignant Disease

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

1988 • 924 citations

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

1997 • 694 citations

Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.

1993 • 611 citations

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

1996 • 581 citations

Transplantation of discordant xenografts: a review of progress

1990 • 538 citations

In VitroEvidence That Metabolic Cooperation Is Responsible for the Bystander Effect Observed with HSVtkRetroviral Gene Therapy

1993 • 425 citations

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

1996 • 418 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose

1993 • 356 citations

Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA.

1990 • 277 citations

Gene Transfer by Retrovirus Vectors Occurs Only in Cells That Are Actively Replicating at the Time of Infection

1990 • 273 citations

A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

1998 • 268 citations

THE EFFECT OF SOLUBLE COMPLEMENT RECEPTOR TYPE 1 ON HYPERACUTE REJECTION OF PORCINE XENOGRAFTS

1994 • 261 citations

Human serum lyses RNA tumour viruses

1975 • 222 citations

Evolution and pathophysiology of the human natural anti-?-galactosyl IgG (anti-Gal) antibody

1993 • 197 citations

Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

1990 • 195 citations

A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody.

1995 • 193 citations

Transfer of the HSV-tk Gene into Donor Peripheral Blood Lymphocytes for In Vivo Modulation of Donor Anti-Tumor Immunity after Allogeneic Bone Marrow Transplantation. The San Raffaele Hospital, Milan, Italy

1995 • 147 citations

An experimental model of retrovirus gene therapy for malignant brain tumors

1993 • 143 citations

A Phase I/II Dose-Escalation Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Metastatic Melanoma

1998 • 90 citations

Selective elimination of recombinant genes in vivo with a suicide retroviral vector.

1991 • 63 citations

Protection of Retroviral Vector Particles in Human Blood Through Complement Inhibition

1995 • 61 citations

Autoimmune diabetes: the role of the islets of langerhans

1996 • 51 citations

The Treatment of Ovarian Cancer with a Gene Modified Cancer Vaccine: A Phase I Study. Tulane University, New Orleans, Louisiana

1995 • 49 citations

Adoptive Immunotherapy for Leukemia: Donor Lymphocytes Transduced with the Herpes Simplex Thymidine Kinase Gene for Remission Induction. Human Gene Therapy Research Institute, Des Moines, Iowa, and Northwestern University School of Medicine, Chicago, Illinois

1998 • 43 citations

Intrathecal Gene Therapy for the Treatment of Leptomeningeal Carcinomatosis. National Institutes of Health, Bethesda, Maryland

1995 • 37 citations

Potential and limitations of HSV-TK-transduced donor peripheral blood lymphocytes after allo-BMT

1997 • 25 citations

Gene therapy for melanoma

1997 • 2 citations