Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments

The acute phase response

1994 • 2,927 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

1990 • 742 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

Functional discrimination between interleukin 6 and interleukin 1

1988 • 443 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 419 citations

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

1993 • 402 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Soluble cytokine receptors: their role in immunoregulation

1991 • 289 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma

1995 • 275 citations

Pharmacokinetics of recombinant interleukin 2 in humans.

1990 • 210 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

1993 • 206 citations

Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.

1993 • 142 citations

Selective and differential binding of interleukin (IL)‐1α, IL‐1β, IL‐2 and IL‐6 to glycosaminoglycans

1992 • 123 citations

Studies on the structure and regulation of the human hepatic interleukin‐6 receptor

1990 • 110 citations

Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo.

1993 • 108 citations

Protective effect of anti‐interleukin (IL)‐6 antibody against endotoxin, associated with paradoxically increased IL‐6 levels

1992 • 105 citations

High amounts of circulating interleukin (IL)‐6 in the form of monomeric immune complexes during anti‐IL‐6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo

1992 • 102 citations

Cytokine-binding proteins: stimulating antagonists

1995 • 94 citations

Phorbol ester modulates interleukin 6- and interleukin 1-regulated expression of acute phase plasma proteins in hepatoma cells.

1988 • 88 citations

On the multimeric nature of natural human interleukin-6

1991 • 69 citations

Human anti-mouse antibody response to the injection of murine monoclonal antibodies against IL-6

1994 • 51 citations

Cytokine antagonists and their potential therapeutic use

1994 • 49 citations

Differential regulation of interleukin-6 receptor and gp130 gene expression in rat hepatocytes.

1992 • 47 citations

Enhancement of the biologic effects of interleukin-3 in vivo by anti- interleukin-3 antibodies

1993 • 44 citations

Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies

1991 • 42 citations

Stable model immune complexes produced by bivalent affinity labeling haptens: In-vivo survival

1979 • 38 citations

Effects of anti‐TNF monoclonal antibody infusion in patients with hairy cell leukaemia

1992 • 11 citations

Computer Calculation of Multiple Binding Equilibrium Isotherms: Application to the Binding of Bivalent Ligands to Antibodies Interacting with Cell Surface Fc-receptors

1993 • 9 citations