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1974 • 3,582 citations

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1991 • 2,563 citations

Combined Chemotherapy and Radiotherapy Compared with Radiotherapy Alone in Patients with Cancer of the Esophagus

1992 • 2,028 citations

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

1957 • 1,528 citations

Prolongation of the Disease-Free Interval in Surgically Treated Rectal Carcinoma

1985 • 1,097 citations

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1979 • 912 citations

Three-dimensional structure of the free radical protein of ribonucleotide reductase

1990 • 833 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

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1960 • 649 citations

Treatment of Locally Unresectable Carcinoma of the Pancreas: Comparison of Combined-Modality Therapy (Chemotheraphy Plus Radiotherapy) to Chemotheraphy Alone1

1988 • 564 citations

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1958 • 436 citations

Repair of Potentially Lethal Damage in X-Irradiated HeLa Cells¹

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Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays

1982 • 391 citations

NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer

1990 • 389 citations

Studies on the Chemical Basis of Cellular Radiosensitization by 5-bromouracil Substitution in DNA

1969 • 356 citations

Hydroxyurea: Differential Lethal Effects on Cultured Mammalian Cells during the Cell Cycle

1965 • 347 citations

Fluorinated Pyrimidines and Their Nucleosides

1975 • 333 citations

Synthesis and biological activities of iododeoxyuridine, an analog of thymidine

1959 • 332 citations

Repair of Potentially Lethal Damage in X-Irradiated HeLa Cells

1966 • 310 citations

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1990 • 288 citations

The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells.

1977 • 210 citations

Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group.

1992 • 204 citations

Adjuvant postoperative radiotherapy and chemotherapy in rectal carcinoma: A review of the gastrointestinal tumor study group experience

1988 • 201 citations

Nonlinear pharmacokinetic models for 5-fluorouracil in man: Intravenous and intraperitoneal routes

1980 • 181 citations

The distribution and fate of bromodeoxyuridine and bromodeoxycytidine in the mouse and rat.

1962 • 175 citations

Definitive Irradiation and Chemotherapy for Radiosensitization in Management of Anal Carcinoma: Interim Report on Radiation Therapy Oncology Group Study No. 8314

1989 • 170 citations

Combined Effect of X Radiation and 5-Fluorouracil on Survival of Transplanted Leukemic Cells<xref ref-type="fn" rid="FN1">2</xref>

1971 • 168 citations

Studies on Ultraviolet Irradiation of Escherichia coli Containing 5-Bromouracil in its DNA

1960 • 163 citations

An overview of the clinical experience with hydroxyurea.

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X-ray sensitization by halopyrimidines.

1974 • 151 citations

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1987 • 145 citations

Combined modality treatment with radiotherapy and chemotherapy

1989 • 145 citations

Impact of improved local control on survival

1986 • 144 citations

INTRA-ARTERIAL 5-BROMODEOXYURIDINE AND X-RAY THERAPY

1967 • 143 citations

Radiation Research : A Twentieth-Century Perspective

1992 • 134 citations

Molecular Radiobiology of Human Cell Lines: V. Comparative Radiosensitizing Properties of 5-Halodeoxycytidines and 5-Halodeoxyuridines

1963 • 127 citations

DNA Damage Induction of Ribonucleotide Reductase

1989 • 122 citations

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1970 • 121 citations

Hydroxyurea: A radiation potentiator in carcinoma of the uterine cervix

1983 • 117 citations

5-Fluorouracil incorporation in DNA of human breast carcinoma cells.

1982 • 117 citations

Hydroxyurea. A New Type of Potential Antitumor Agent¹

1963 • 114 citations

The combined effect of hydroxyurea and x-rays on Chinese hamster cells in vitro.

1968 • 109 citations

Patterns of treatment failure and prognostic factors associated with the treatment of esophageal carcinoma with chemotherapy and radiotherapy either as sole treatment or followed by surgery .

1992 • 106 citations

Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.

1982 • 102 citations

A Phase III comparison of BCNU, hydroxyurea, and radiation therapy to BCNU and radiation therapy for treatment of primary malignant gliomas

1979 • 102 citations

A phase i study of intermittent intravenous bromodeoxyuridine (BUdR) with conventional fractionated irradiation

1984 • 99 citations

Molecular radiobiology of human cell lines. I. Comparative sensitivity to X-rays and ultraviolet light of cells containing halogen-substituted DNA

1961 • 99 citations

Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

1988 • 96 citations

Pharmacology and phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme.

1988 • 96 citations

Initial clinical studies with 5-iodo-2'-deoxyuridine.

1961 • 95 citations

Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial.

1993 • 94 citations

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.

1987 • 93 citations

Molecular Radiobiology of Human Cell Lines: III. Radiation-sensitizing Properties of 5-Iododeoxyuridine

1963 • 89 citations

Free-radical Formation in Irradiated Deoxyribonucleic Acid

1965 • 89 citations

Pharmacokinetics of the fluoropyrimidines: implications for their clinical use

1976 • 89 citations

Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells

1990 • 86 citations

Hydroxyurea and Radiotherapy in Head and Neck Cancer

1971 • 86 citations

Radiosensitization of Malignant Brain Tumours with Bromouridine (Thymidine Analogue)

1969 • 85 citations

A phase i study of intravenous iododeoxyuridine as a clinical radiosensitizer

1985 • 81 citations

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DNA damage induction of ribonucleotide reductase.

1989 • 77 citations

Cancer Chemotherapy by Infusion

1987 • 75 citations

5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cells

1991 • 74 citations

Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase

1989 • 73 citations

The incorporation of uracil into animal cell DNA in vitro

1978 • 71 citations

Linear-Quadratic Analysis of Radiosensitization by Halogenated Pyrimidines: II. Radiosensitization of Human Colon Cancer Cells by Bromodeoxyuridine

1992 • 70 citations

A REVIEW OF SOME ASPECTS OF 5-IODODEOXYURIDINE AND AZAURIDINE.

1963 • 70 citations

Continuous intravenous infusions of bromodeoxyuridine as a clinical radiosensitizer.

1984 • 69 citations

Studies on the Chemical Basis of Cellular Radiosensitization by 5-bromouracil Substitution in DNA

1969 • 69 citations

Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis

1982 • 67 citations

HYDROXYUREA: A RADIOSENSITIZER IN THE TREATMENT OF NEOPLASMS OF THE HEAD AND NECK

1969 • 65 citations

The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure

1990 • 63 citations

Preferential Radiosensitization of Mouse Sarcoma Relative to Normal Skin by Chronic Intra-Arterial Infusion of Halogenated Pyrimidine Analogs<xref ref-type="fn" rid="FN2">2</xref>

1971 • 63 citations

Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.

1992 • 60 citations

Hydroxyurea: effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells

1987 • 58 citations

Long-term follow-up on National Cancer Institute Phase I/II study of glioblastoma multiforme treated with iododeoxyuridine and hyperfractionated irradiation.

1992 • 57 citations

Halogenated Pyrimidines as Radiosensitizers in the Treatment of Glioblastoma Multiforme

1987 • 55 citations

Hydroxyurea plus pelvic irradiation versus placebo plus pelvic irradiation in nonsurgically staged stage IIIB cervical cancer

1989 • 55 citations

Bromodeoxyuridine Dependence—A New Mutation in Mammalian Cells

1973 • 54 citations

A phase I study of hydroxyurea.

1963 • 54 citations

5-fluorouracil infusions and fractionated doses of radiation: Studies with a murine squamous cell carcinoma

1987 • 50 citations

Intra-arterial bromodeoxyuridine radiosensitization of malignant gliomas

1990 • 48 citations

Incorporation of 5-fluorouracil into murine bone marrow DNA in vivo.

1984 • 46 citations

Inhibition of the growth of mouse leukemia cells in culture by 5-iododeoxyuridine

1959 • 45 citations

The Effect of 5-Bromouracil on Energy Transfer in DNA and Related Model Systems: DNA with Incorporated 5-BUdR

1971 • 43 citations

Suppression by cysteamine of radiosensitization in 5-bromodeoxyuridine substituted phage T1

1963 • 41 citations

Kinetics of cell labelling and thymidine replacement after continuous infusion of halogenated pyrimidines in vivo

1994 • 40 citations

A phase I study of intraarterial iododeoxyuridine in patients with colorectal liver metastases.

1989 • 39 citations

Interaction of the Oxygen Effect and Radiosensitization Produced by Base Analogues Incorporated into Deoxyribonucleic Acid

1962 • 37 citations

Effects of combined roentgen irradiation and chemotherapy on transplanted tumors in mice.

1961 • 36 citations

The experimental and clinical rationale for the use of S-phase-specific radiosensitizers to overcome tumor cell repopulation.

1992 • 35 citations

Effect of Oxygen in Mammalian Cells Sensitized to Radiation by Incorporation of 5-Bromodeoxyuridine into the DNA

1963 • 34 citations

Hydroxyurea in the treatment of neoplasms of the head and neck

1973 • 33 citations

Effects of 5′-iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double strand breaks in chinese hamster ovary cells

1992 • 32 citations

High‐dose intravenous and hepatic artery infusions of thymidine

1978 • 32 citations

Hydroxyurea revisited: A decade of clinical effects studies

1981 • 31 citations

Comparison of Intravenous and Intra-arterial Pyrimidine Infusion as a Means of Radiosensitizing TumorsIn Vivo

1977 • 31 citations

Effect of 1-β-D-arabinofuranosyl cytosine and hydroxyurea on the repair of X-ray-induced DNA single-strand breaks in human leukemic blasts

1985 • 30 citations

Linear-Quadratic Analysis of Radiosensitization by Halogenated Pyrimidines: I. Radiosensitization of Human Colon Cancer Cells by Iododeoxyuridine

1992 • 30 citations

Effect of hydroxyurea on the radiation response of C3H mouse mammary tumors

1972 • 28 citations

Clinical and pharmacological studies with 5-iodo-2'-deoxycytidine.

1963 • 28 citations

INCORPORATION OF I-125-LABELED IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF MURINE AND HUMAN TISSUES FOLLOWING THERAPEUTIC DOSES.

1963 • 28 citations

Enhancement of the antitumor activity of 5-fluorouracil by drug combinations.

1973 • 25 citations

Fluorodeoxyuridine modulation of the incorporation of iododeoxyuridine into DNA of granulocytes: a phase I and clinical pharmacological study.

1988 • 23 citations

Phase i trial of postoperative 5-FU, radiation therapy, and high dose leucovorin for resectable rectal cancer

1992 • 23 citations

The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization

1991 • 22 citations

The place of hydroxyurea in the treatment of primary brain tumors.

1992 • 21 citations

Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition.

1990 • 21 citations

Transitional cell carcinoma of the urinary bladder: histologic clearance with combined 5-FU chemotherapy and radiation therapy. Preliminary results of a bladder-preservation study.

1988 • 21 citations

Iododeoxyuridine incorporation and radiosensitization in three human tumor cell lines

1992 • 18 citations

The diverse effects of 5′‐bromodeoxyuridine on enzyme activities in cultured H35 hepatoma cells

1977 • 17 citations

Hydroxyurea with concomitant radiotherapy for locally advanced head and neck cancer.

1992 • 17 citations

The effects of 5-iodo-2'-deoxyuridine upon the replication of ileal and spleen cells in vivo.

1969 • 16 citations

Modification of Radiation Effect on Mammalian Tumour Cells by Pharmacological Agents

1962 • 16 citations

The effect of 5-bromouracil on energy transfer in DNA and related model systems. Purine: pyrimidine crystal complexes.

1971 • 16 citations

RADIOSENSITIZATION BY THE HALOGENATED PYRIMIDINE ANALOGUES: LABORATORY AND CLINICAL INVESTIGATIONS.

1970 • 15 citations

5-Bromodeoxyuridine Specifically Inhibits the Synthesis of Estrogen-Induced Proteins in MCF7 Cells

1981 • 15 citations

Theoretical Evaluation of a Limitation in the Use of Pyrimidine Analogs in Radiation Therapy

1966 • 14 citations

Modulation of iododeoxyuridine-mediated radiosensitization by 5-fluorouracil in human colon cancer cells

1992 • 13 citations

Progressive formation of DNA lesions during treatment with anti-metabolites without incorporation of the drugs into DNA

1988 • 12 citations

The effect of natural and unnatural pyrimidines and pyrimidine nucleosides on the phosphorolysis of 5-iododeoxyuridine by mouse liver extract

1964 • 10 citations

The Effect of 5-Bromouracil on Energy Transfer in DNA and Related Model Systems. Purine: Pyrimidine Crystal Complexes

1971 • 10 citations

Cancer chemotherapy by infusion

1989 • 9 citations

Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: A preliminary report

1980 • 9 citations

Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.

1984 • 8 citations

RATIONALE FOR AND EXPERIENCE WITH CLINICAL TRIALS OF HALOGENATED PYRIMIDINES IN MALIGNANT GLIOMAS: THE UCSF/NCOG EXPERIENCE

1992 • 6 citations

Measurement of the in vivo Degradation of Carbon-14-labelled Thymidine and Its Halogenated Analogues in Man by Continuous Monitoring of Expired Carbon-14-Carbon Dioxide

1964 • 5 citations

Basis for the differential modulation of the uptake of 5-iododeoxyuridine by 5'-aminothymidine among various cell types.

1989 • 4 citations