Hydroxyurea: effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

NUCLEOSIDE-PHOSPHORYLASE DEFICIENCY IN A CHILD WITH SEVERELY DEFECTIVE T-CELL IMMUNITY AND NORMAL B-CELL IMMUNITY

1975 • 855 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

1971 • 280 citations

A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts

1979 • 272 citations

Nuclear and Cytoplasmic Pools of Deoxyribonucleoside Triphosphates in Chinese Hamster Ovary Cells

1974 • 145 citations

Deoxyribonucleoside‐Triphosphate Pools and DNA Synthesis in Synchronized Hamster Cells

1973 • 136 citations

Inhibition of DNA excision repair in human cells by arabinofuranosyl cytosine: effect on normal and xeroderma pigmentosum cells.

1979 • 135 citations

The inhibition of repair in UV irradiated human cells

1977 • 119 citations

The role of deoxynucleoside triphosphate pools in the inhibition of DNA-excision repair and replication in human cells by hydroxyurea

1984 • 103 citations

DNA precursor pools and ribonucleotide reductase activity: distribution between the nucleus and cytoplasm of mammalian cells.

1985 • 98 citations

Control of deoxyribonucleotide synthesis in vitro and in vivo

1972 • 94 citations

Initial rates of DNA incision in UV-irradiated human cells differences between normal, xeroderma pigmentosum and tumour cells

1982 • 89 citations

Role of deoxynucleoside triphosphate pools in the cytotoxic and mutagenic effects of DNA alkylating agents

1981 • 84 citations

Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation

1981 • 82 citations

Inhibitors of repair DNA synthesis

1982 • 80 citations

Deoxyribonucleoside 5′-triphosphate pool fluctuations during the mamalian cell cycle

1972 • 79 citations

DNA damage in ultraviolet-irradiated HeLa and CHO-Kl cells examined by alkaline lysis and hydroxyapatite chromatography

1977 • 77 citations

Dynamics of pyrimidine deoxynucleoside triphosphate pools in relationship to DNA synthesis in 3T6 mouse fibroblasts.

1983 • 76 citations

Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts.

1985 • 71 citations

Evidence for the involvement of substrate cycles in the regulation of deoxyribonucleoside triphosphate pools in 3T6 cells.

1985 • 67 citations

Sensitivity of excision repair in normal human, xeroderma pigmentosum variant and Cockayne's syndrome fibroblasts to inhibition by cytosine arabinoside

1981 • 53 citations

The Inhibition of DNA Repair

1984 • 43 citations

Cell cycle‐related variations in UV damage and repair capacity in chinese hamster (CHO‐K1) cells

1980 • 39 citations

Dependence of u.v.-induced DNA excision repair on deoxyribonucleoside triphosphate concentrations in permeable human fibroblasts: a model for the inhibition of repair by hydroxyurea

1985 • 26 citations

DNA repair in ultraviolet-irradiated HeLa cells is disrupted by aphidicolin

1983 • 25 citations

DNA Repair Under Stress

1987 • 24 citations

The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides

1984 • 24 citations

Kinetics of UV-induced changes in deoxynucleoside triphosphate pools in Chinese hamster ovary cells and their effect on measurements of DNA synthesis

1983 • 22 citations

A survey of dna repair incision activities after ultraviolet irradiation of a range of human, hamster, and hamster-human hybrid cell lines

1982 • 22 citations

Analysis of generalized two-dimensional homonuclear nmr spectra

1981 • 21 citations

Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells.

1984 • 10 citations

Inhibition by aphidicolin and dideoxythymidine triphosphate of a multienzyme complex of DNA synthesis from human cells

1983 • 8 citations