Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis

[73] Spectrophotometric and turbidimetric methods for measuring proteins

1957 • 3,309 citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

A Sensitive Colorimetric Method for the Estimation of 2-Deoxy Sugars with the Use of the MalonaldehydeThiobarbituric Acid Reaction

1959 • 480 citations

Studies on Fluorinated Pyrimidines

1961 • 419 citations

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1978 • 175 citations

Fluorinated pyrimidines. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

1974 • 172 citations

Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds

1970 • 141 citations

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1981 • 137 citations

The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.

1978 • 133 citations

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

1975 • 121 citations

Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells.

1980 • 110 citations

Antineoplastic and Immunosuppressive Agents.

1975 • 109 citations

Nucleic acids. IV. Catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors)

1967 • 92 citations

The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.

1969 • 88 citations

Pharmacological Basis of Cancer Chemotherapy.

1975 • 85 citations

Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.

1970 • 80 citations

A ten-year study of 5-flurouracil in disseminated breast cancer with clinical results and survival times..

1969 • 52 citations

Assay of 5-fluorodeoxyuridine 5'-monophosphate deoxyuridine 5'-monophosphate pools following 5-fluorouracil.

1974 • 50 citations

Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response

1978 • 49 citations

The mechanism of 5-fluorouridine toxicity in Novikoff hepatoma cells.

1976 • 49 citations

Tetrahydrodeoxyuridylate: A potent inhibitor of deoxycytidylate deaminase

1971 • 43 citations

Drug resistance and selectivity. Biochemical and cellular basis

1975 • 37 citations

Chemotherapy of Gastrointestinal Cancer

1967 • 36 citations

Sequential Blockage as a Theoretical Basis for Drug Synergism

1963 • 28 citations

Methods for the separation and identification of ribonucleotides on DEAE-cellulose

1973 • 24 citations

Chemotherapy of colorectal carcinoma.

1976 • 15 citations

[14] The thiobarbituric acid method for deoxyribonucleosides

1967 • 14 citations

Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy.

1965 • 12 citations