Nitric Oxide Synergistically Enhances DNA Strand Breakage Induced by Polyhydroxyaromatic Compounds, but Inhibits That Induced by the Fenton Reaction

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

[23] Oxidative chemistry of peroxynitrite

1994 • 981 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Nitric oxide as an antioxidant

1991 • 441 citations

Potential genotoxicity of chronically elevated nitric oxide: A review

1995 • 385 citations

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

1995 • 343 citations

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.

1996 • 322 citations

Intense oxidative DNA damage promoted by <scp>l</scp>‐DOPA and its metabolites implications for neurodegenerative disease

1994 • 294 citations

Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro

1995 • 289 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli.

1995 • 258 citations

A stable solid that generates hydroxyl radical upon dissolution in aqueous solutions: reaction with proteins and nucleic acid

1992 • 229 citations

DNA damage resulting from the oxidation of hydroquinone by copper: role for a Cu(II)/Cu(I) redox cycle and reactive oxygen generation

1993 • 226 citations

Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance

1995 • 215 citations

Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide‐mediated killing

1993 • 196 citations

Peroxynitrite Causes DNA Nicks in Plasmid pBR322

1995 • 185 citations

Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA

1996 • 174 citations

Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite

1996 • 168 citations

The Chemistry and Tumoricidal Activity of Nitric Oxide/Hydrogen Peroxide and the Implications to Cell Resistance/Susceptibility

1996 • 162 citations

Chemical synthesis with a quenched flow reactor. Hydroxytrihydroborate and peroxynitrite

1974 • 149 citations

Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide

1993 • 127 citations

The biology of nitric oxide, part 5

1996 • 102 citations

Nitric Oxide Protects against the Cytotoxic Effects of Reactive Oxygen Species

1994 • 99 citations

An Adduct between Peroxynitrite and 2‘-Deoxyguanosine: 4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine

1996 • 90 citations

Inflammation and Cancer

2009 • 88 citations

Nitric oxide-induced nitration of catecholamine neurotransmitters: A key to neuronal degeneration?

1995 • 66 citations

The Antioxidant Effect of Spermine NONOate in Human Low-Density Lipoprotein

1995 • 60 citations

Peripheral T-cell lymphoma in childhood and adolescence a clinicopathologic study of 22 patients

1993 • 54 citations

A New Perspective on the Inhibitory Role of Nitric Oxide in Sympathetic Neurotransmission

1995 • 52 citations

DNA Damage and Cytotoxicity Caused by Nitric Oxide

1994 • 36 citations

Modulation of DNA breakage induced via the Fenton reaction

1993 • 24 citations

Strand Scission in DNA Induced by S-Nitrosothiol with Hydrogen Peroxide

1994 • 5 citations