Heat shock protein 70: role in antigen presentation and immune stimulation

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

A new puffing pattern induced by temperature shock and DNP in drosophila

1962 • 1,969 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

2002 • 1,483 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Role of the Major Heat Shock Proteins as Molecular Chaperones

1993 • 1,096 citations

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

2000 • 1,028 citations

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

2002 • 949 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Hyperthermia in oncology

2001 • 638 citations

Heat shock protein 70-associated peptides elicit specific cancer immunity.

1993 • 631 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma

1995 • 557 citations

Chlamydial Heat Shock Protein 60 Localizes in Human Atheroma and Regulates Macrophage Tumor Necrosis Factor-α and Matrix Metalloproteinase Expression

1998 • 546 citations

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages

1999 • 517 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways

2000 • 407 citations

Cutting Edge: Receptor-Mediated Endocytosis of Heat Shock Proteins by Professional Antigen-Presenting Cells

1999 • 399 citations

Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.

1997 • 392 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

Expression of human HSP70 during the synthetic phase of the cell cycle.

1986 • 316 citations

Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells

2001 • 260 citations

Lipopolysaccharide (LPS) Signal Transduction and Clearance

1995 • 260 citations

Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells

2002 • 255 citations

Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: A pilot study

2000 • 250 citations

Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells

1999 • 219 citations

Heat Shock Protein-chaperoned Peptides but Not Free Peptides Introduced into the Cytosol Are Presented Efficiently by Major Histocompatibility Complex I Molecules

2001 • 218 citations

The role of heat shock protein (hsp70) in dendritic cell maturation: Hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

2001 • 208 citations

Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock Protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes

1998 • 193 citations

Cell surface expression of heat shock proteins and the immune response

1996 • 177 citations

Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells.

2001 • 173 citations

Evolution of effectors and receptors of innate immunity

2001 • 166 citations

Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity

2001 • 165 citations

Cell Surface Targeting of Heat Shock Protein gp96 Induces Dendritic Cell Maturation and Antitumor Immunity

2001 • 161 citations

Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms

1993 • 159 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view

2000 • 153 citations

Immunotherapy of human cancer: lessons from mice

2000 • 143 citations

CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells

1995 • 140 citations

Heat shock protein-peptide complexes in cancer immunotherapy

1994 • 140 citations

Cancer and the heat shock response

1994 • 138 citations

Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes

1997 • 138 citations

Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.

1996 • 128 citations

The role of Toll-like receptors and MyD88 in innate immune responses

2000 • 104 citations

Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-γ production in T cells

2001 • 100 citations

Isolation of processed, H-2Kb -binding ovalbumin-derived peptides associated with the stress proteins HSP70 and GP96

1998 • 96 citations

The HSC73 Molecular Chaperone: Involvement in MHC Class II Antigen Presentation

1999 • 93 citations

Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70

2001 • 91 citations

The Role of Heat Shock Proteins and Their Receptors in the Activation of the Immune System

2001 • 79 citations

Hyperthermia in oncology

2001 • 77 citations

Heat-shock protein-based anticancer immunotherapy: an idea whose time has come.

1998 • 70 citations

Noncovalent Association with Stress Protein Facilitates Cross-Priming of CD8+ T Cells to Tumor Cell Antigens by Dendritic Cells

2002 • 53 citations

Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells.

2000 • 47 citations

Hyperthermia in the treatment of cancer: Perspectives on its promise and its problems

1984 • 47 citations

In vivo biological activities of endotoxin.

1985 • 23 citations

Possible Mechanisms for Tumour Cell Sensitivity to TNF-a and Potential Therapeutic Applications

2001 • 16 citations

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