KEX2 Influences Candida albicans Proteinase Secretion and Hyphal Formation

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Methods in Yeast Genetics: A Laboratory Course Manual

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Isogenic strain construction and gene mapping in Candida albicans.

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Methods in Yeast Genetics — A Laboratory Course Manual

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Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations

1984 • 1,198 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

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Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

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A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

1987 • 408 citations

High-Frequency Switching of Colony Morphology in Candida albicans

1985 • 405 citations

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions

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Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans

1994 • 374 citations

Centromeric DNA from Saccharomyces cerevisiae

1982 • 292 citations

[52] Staining of bud scars and other cell wall chitin with Calcofluor

1991 • 272 citations

Multiplicity of genes encoding secreted aspartic proteinases in Candida species

1994 • 251 citations

Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases

1988 • 236 citations

Serum-proteins as nitrogen source for yeastlike fungi

1966 • 226 citations

Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors

1995 • 211 citations

Variations in fluconazole susceptibility and electrophoretic karyotype among oral isolates of Candida albicans from patients with AIDS and oral candidiasis

1994 • 205 citations

Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid

1997 • 181 citations

Developmental Expression of a Tandemly Repeated, Proline- and Glutamine-rich Amino Acid Motif on Hyphal Surfaces of Candida albicans

1996 • 174 citations

Three distinct secreted aspartyl proteinases in Candida albicans

1993 • 163 citations

Candida and Candidosis

1988 • 136 citations

A novel class of small amphipathic peptides affect aerial hyphal growth and surface hydrophobicity in Ustilago maydis.

1996 • 127 citations

Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus

1996 • 123 citations

The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors

1995 • 119 citations

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

1991 • 118 citations

Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes

1993 • 108 citations

Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients

1995 • 106 citations

Candidaacid proteinases

1992 • 100 citations

An oligopeptide transport gene from Candida albicans

1997 • 99 citations

A chromosomal gene required for killer plasmid expression, mating, and spore maturation in Saccharomyces cerevisiae.

1976 • 99 citations

Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast.

1995 • 96 citations

A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease.

1994 • 93 citations

An exo- -(1,3)-glucanase of Candida albicans: purification of the enzyme and molecular cloning of the gene

1993 • 78 citations

In-vitro proteinase production by oral Candida albicans isolates from individuals with and without HIV infection and its attenuation by antimycotic agents

1996 • 78 citations

Candida albicans isolates from HIV-infected and AIDS patients exhibit enhanced adherence to epithelial cells

1995 • 69 citations

Expression of surface hydrophobic proteins by Candida albicans in vivo

1995 • 69 citations

Segregation of Proteinase-negative Mutants from Heterozygous Candida albicans

1987 • 66 citations

Allele-Specific Suppression of a Defective trans-Golgi Network (TGN) Localization Signal in Kex2p Identifies Three Genes Involved in Localization of TGN Transmembrane Proteins

1996 • 65 citations

Cloning, nucleotide sequence and functions of XPR6, which codes for a dibasic processing endoprotease from the yeast Yarrowia lipolytica

1994 • 61 citations

The role ofCandida albicans secreted aspartic proteinase in the development of candidoses

1996 • 56 citations

Isolation and characterization of krp, a dibasic endopeptidase required for cell viability in the fission yeast Schizosaccharomyces pombe.

1994 • 55 citations

Acid Proteinase Secreted by Candida Tropicalis: Functional Analysis of Preproregion Cleavages in C. Tropicalis and Saccharomyces Cerevisiae

1996 • 52 citations

The Kluyveromyces lactis KEX1 gene encodes a subtilisin‐type serine proteinase

1988 • 51 citations

Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector

1995 • 51 citations

Molecular biology of yeast exoglucanases

1995 • 50 citations

Increased phenotypic switching in strains of Candida albicans associated with invasive infections

1994 • 49 citations

Synthesis of Tight Binding Inhibitors and Their Action on the Proprotein-Processing Enzyme Furin

1995 • 46 citations

Heterogeneity of the purified extracellular aspartyl proteinase from Candida albicans: characterization with monoclonal antibodies and N-terminal amino acid sequence analysis

1993 • 42 citations

Recombinant canditropsin, an extracellular aspartic protease from yeast Candida tropicalis. Escherichia coli expression, purification, zymogen activation, and enzymic properties.

1993 • 34 citations

Saccharomyces cerevisiae killer expression mutant kex2 has altered secretory proteins and glycoproteins

1979 • 31 citations

Pathogenesis of invasive candidiasis

1994 • 16 citations

Heterologous Expression and Site‐Directed Mutagenesis Studies on the Activation Mechanism and the Roles of the Basic Residues in the Prosegment of Aspergillopepsinogen I

1996 • 14 citations

Expression pattern of aspartic proteinase antigens in aspergilli

1996 • 13 citations

Ultrastructure of proteinase-secreting cells of Candida albicans studied by alkaline bismuth staining and immunocytochemistry

1993 • 11 citations

Sequence of the Saccharomyces cerevisiae YTP1 gene encoding a deduced novel type-III integral membrane protein with domains of sequence similarity to mitochondrial electron-transport enzymes

1996 • 9 citations