The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

The Structure and Function of the Aspartic Proteinases

1990 • 637 citations

PUTATIVE VIRULENCE FACTORS OF CANDIDA ALBICANS

1991 • 632 citations

Assessment of phase accuracy by cross validation: the free R value. Methods and applications

1993 • 451 citations

Determination of Absolute from Relative X-Ray Intensity Data

1942 • 423 citations

Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans

1994 • 374 citations

A restrained-parameter thermal-factor refinement procedure

1980 • 312 citations

The γ Turn, a Possible Folded Conformation of the Polypeptide Chain. Comparison with the β Turn

1972 • 271 citations

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.

1993 • 269 citations

Multiplicity of genes encoding secreted aspartic proteinases in Candida species

1994 • 251 citations

Critical role of germ tube formation in the pathogenesis of candidal vaginitis

1984 • 249 citations

Serum-proteins as nitrogen source for yeastlike fungi

1966 • 226 citations

Pathogenesis of Candida infections

1994 • 220 citations

INDUCIBLE PROTEINASE OF CANDIDA ALBICANS IN DIAGNOSTIC SEROLOGY AND IN THE PATHOGENESIS OF SYSTEMIC CANDIDOSIS

1980 • 200 citations

Improvement of macromolecular electron-density maps by the simultaneous application of real and reciprocal space constraints

1993 • 194 citations

The Emerging Fungal Threat

1994 • 182 citations

Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.

1993 • 161 citations

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

1982 • 148 citations

Isolation and Characterization of Proteinase from Candida albicans: Substrate Specificity

1984 • 143 citations

Distribution of Attack on Iron or Zinc Partly Immersed in Chloride Solutions

1942 • 141 citations

X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins

1992 • 138 citations

Molecular replacement

1992 • 137 citations

The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant

1990 • 127 citations

Revised 2.3 Å structure of porcine pepsin: Evidence for a flexible subdomain

1990 • 117 citations

The three‐dimensional structure of recombinant bovine chymosin at 2.3 Å resolution

1990 • 115 citations

The use of Sayre's equation with solvent flattening and histogram matching for phase extension and refinement of protein structures

1990 • 114 citations

High-frequency phenotypic switching in Candida albicans

1993 • 112 citations

Domain flexibility in aspartic proteinases

1992 • 100 citations

Candidaacid proteinases

1992 • 100 citations

Molecular replacement

1992 • 92 citations

A second gene for a secreted aspartate proteinase in Candida albicans

1992 • 90 citations

X-ray analyses of aspartic proteinases

1990 • 89 citations

Comparative production and rapid purification of Candida acid proteinase from protein-supplemented cultures

1990 • 78 citations

Innovations in proteases and their inhibitors

1994 • 58 citations

Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase

1992 • 48 citations

X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin

1993 • 48 citations

X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.

1993 • 46 citations

Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor

1992 • 40 citations

A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica

1994 • 34 citations

Innovations in Proteases and Their Inhibitors

1993 • 34 citations

Structures of complexes of rhizopuspepsin with pepstatin and other statine‐containing inhibitors

1992 • 32 citations

Crystallization of Inhibited Aspartic Proteinase from Candida albicans

1993 • 17 citations