Allele-Specific Suppression of a Defective trans-Golgi Network (TGN) Localization Signal in Kex2p Identifies Three Genes Involved in Localization of TGN Transmembrane Proteins

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

Methods in Yeast Genetics — A Laboratory Course Manual

1991 • 1,257 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae

1979 • 518 citations

The purified E. coli integral membrane protein is sufficient for reconstitution of SecA-dependent precursor protein translocation

1990 • 516 citations

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

1994 • 500 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

[76] β-d-Fructofuranoside fructohydrolase from yeast

1975 • 455 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

[31] Tackling the protease problem in Saccharomyces cerevisiae

1991 • 427 citations

Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.

1991 • 415 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

Suppressor mutations that restore export of a protein with a defective signal sequence

1981 • 382 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

Glucose repression in the yeast Saccharomyces cerevisiae

1992 • 347 citations

Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase.

1989 • 330 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

1984 • 310 citations

Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae.

1991 • 268 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

1991 • 247 citations

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

1991 • 246 citations

Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus

1994 • 243 citations

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

1993 • 239 citations

TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain.

1993 • 231 citations

A temperature-sensitive mutant of E. coli exhibiting slow processing of exported proteins

1983 • 215 citations

An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.

1995 • 215 citations

Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole.

1992 • 209 citations

Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.

1990 • 199 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment.

1992 • 179 citations

THE SYNTHESIS AND FUNCTION OF PROTEASES IN SACCHAROMYCES: GENETIC APPROACHES

1984 • 179 citations

Sorting of membrane proteins in the secretory pathway

1993 • 171 citations

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1994 • 169 citations

The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn

1991 • 165 citations

The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.

1995 • 157 citations

Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein

1989 • 154 citations

Yeast vacuolar proenzymes are sorted in the late Golgi complex and transported to the vacuole via a prevacuolar endosome-like compartment.

1993 • 152 citations

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene.

1986 • 151 citations

Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues.

1993 • 148 citations

Selective and immediate effects of clathrin heavy chain mutations on Golgi membrane protein retention in Saccharomyces cerevisiae.

1992 • 147 citations

TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.

1993 • 143 citations

The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network.

1994 • 134 citations

Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

1991 • 118 citations

Golgi retention signals: do membranes hold the key?

1991 • 106 citations

Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae.

1994 • 101 citations

Sorting of membrane proteins in the yeast secretory pathway.

1994 • 95 citations

Yeast Kex1p is a Golgi-associated membrane protein: deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane.

1992 • 92 citations

The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway.

1994 • 90 citations

Yeast KEX2 protease and mannosyltransferase I are localized to distinct compartments of the secretory pathway

1989 • 81 citations

[9] Spore enrichment

1991 • 66 citations

The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p.

1996 • 45 citations

Immunoisolation of Kex2p-containing organelles from yeast demonstrates colocalisation of three processing proteinases to a single Golgi compartment

1993 • 40 citations

An efficient procedure for multiple transformations of yeast in parallel.

1993 • 8 citations