The Mechanism for Acetylcholine Receptor Inhibition by α-Neurotoxins and Species-Specific Resistance to α-Bungarotoxin Revealed by NMR

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

NMR of Proteins and Nucleic Acids

2006 • 5,989 citations

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

1992 • 3,627 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Gradient-Tailored Water Suppression for 1H-15N HSQC Experiments Optimized to Retain Full Sensitivity

1993 • 1,113 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Protein structures in solution by nuclear magnetic resonance and distance geometry

1987 • 569 citations

From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor

1998 • 544 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor

1989 • 279 citations

Snake venom α‐neurotoxins and other ‘three‐finger’ proteins

1999 • 272 citations

Structure of nicotinic acetylcholine receptors

1993 • 234 citations

Nicotinic receptors in wonderland

2001 • 166 citations

NMR of macromolecules

1977 • 156 citations

How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor.

1992 • 130 citations

The Binding Site of Acetylcholine Receptor as Visualized in the X-Ray Structure of a Complex between α-Bungarotoxin and a Mimotope Peptide

2001 • 129 citations

Restoration of 125I-alpha-bungarotoxin binding activity to the alpha subunit of Torpedo acetylcholine receptor isolated by gel electrophoresis in sodium dodecyl sulfate.

1981 • 128 citations

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra

1995 • 104 citations

NMR solution structure of an .alpha.-bungarotoxin/nicotinic receptor peptide complex

1993 • 94 citations

Structural studies of .alpha.-bungarotoxin. 1. Sequence-specific proton NMR resonance assignments

1988 • 75 citations

The Binding Site of the Nicotinic Acetylcholine Receptor in Animal Species Resistant to .alpha.-Bungarotoxin

1995 • 72 citations

NMR Structural Analysis of α-Bungarotoxin and Its Complex with the Principal α-Neurotoxin-binding Sequence on the α7 Subunit of a Neuronal Nicotinic Acetylcholine Receptor

2002 • 67 citations

A β-hairpin structure in a 13-mer peptide that binds α-bungarotoxin with high affinity and neutralizes its toxicity

2001 • 64 citations

.alpha.-Bungarotoxin and the competing antibody WF6 interact with different amino acids within the same cholinergic subsite

1991 • 57 citations

Chimeric Analysis of a Neuronal Nicotinic Acetylcholine Receptor Reveals Amino Acids Conferring Sensitivity to α-Bungarotoxin

1999 • 57 citations

Characterization of the binding of alpha-bungarotoxin to bacterially expressed cholinergic binding sites.

1988 • 54 citations

Distribution of alpha-bungarotoxin binding sites over residues 173-204 of the alpha subunit of the acetylcholine receptor.

1988 • 53 citations

Comparison of the toxin binding sites of the nicotinic acetylcholine receptor from Drosophila to human

1990 • 52 citations

Design and synthesis of peptides that bind α-bungarotoxin with high affinity

2001 • 49 citations

The Solution Structure of the Complex Formed between α-Bungarotoxin and an 18-mer Cognate Peptide Derived from the α1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica

2001 • 47 citations

Pairwise Electrostatic Interactions between α-Neurotoxins and γ, δ, and ε Subunits of the Nicotinic Acetylcholine Receptor

2000 • 45 citations

Three-dimensional solution structure of the complex of α-bungarotoxin with a library-derived peptide

1997 • 37 citations

Orientation of α-Neurotoxin at the Subunit Interfaces of the Nicotinic Acetylcholine Receptor

2000 • 34 citations

NMR Structure of α-Bungarotoxin Free and Bound to a Mimotope of the Nicotinic Acetylcholine Receptor

2002 • 26 citations

Probing the Agonist Domain of the Nicotinic Acetylcholine Receptor by Cysteine Scanning Mutagenesis Reveals Residues in Proximity to the α-Bungarotoxin Binding Site

1999 • 22 citations

Effects of mutations of Torpedo acetylcholine receptor .alpha.1 subunit residues 184-200 on .alpha.-bungarotoxin binding in a recombinant fusion protein

1993 • 21 citations

NMR Mapping and Secondary Structure Determination of the Major Acetylcholine Receptor α-Subunit Determinant Interacting with α-Bungarotoxin^,

2001 • 21 citations

How do snake curaremimetic toxins discriminate between nicotinic acetylcholine receptor subtypes

1998 • 17 citations

NMR mapping and secondary structure determination of the major acetylcholine receptor alpha-subunit determinant interacting with alpha-bungarotoxin.

2001 • 17 citations

Structural studies of α-bungarotoxin. 1. Sequence-specific 1 H NMR resonance assignments

1988 • 9 citations

The Mongoose Neuronal Acetylcholine Receptor (α7) Binds α‐Bungarotoxin

1998 • 3 citations