A Novel Binding Protein Composed of Homophilic Tetramer Exhibits Unique Properties for the Small GTPase Rab5

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

1992 • 648 citations

Phosphatidylinositol-3-OH kinases are Rab5 effectors

1999 • 625 citations

Rab 7: an important regulator of late endocytic membrane traffic.

1995 • 625 citations

A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function

1997 • 586 citations

Rab9 functions in transport between late endosomes and the trans Golgi network.

1993 • 556 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Rab5 regulates motility of early endosomes on microtubules

1999 • 504 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

2000 • 373 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.

1993 • 318 citations

Ras-Activated Endocytosis Is Mediated by the Rab5 Guanine Nucleotide Exchange Activity of RIN1

2001 • 307 citations

Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.

1990 • 305 citations

The rab7 gtpase resides on a vesicular compartment connected to lysosomes

1995 • 297 citations

The small GTP-binding protein rab4 is associated with early endosomes.

1991 • 286 citations

The Stress-Induced MAP Kinase p38 Regulates Endocytic Trafficking via the GDI:Rab5 Complex

2001 • 281 citations

A novel role for Rab5–GDI in ligand sequestration into clathrin-coated pits

1998 • 273 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

Epidermal Growth Factor and Membrane Trafficking

2000 • 233 citations

Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound rab4 and rab5

1998 • 218 citations

Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI

1997 • 218 citations

Yeast Homotypic Vacuole Fusion: A Window on Organelle Trafficking Mechanisms

2000 • 214 citations

Functional Synergy between Rab5 Effector Rabaptin-5 and Exchange Factor Rabex-5 When Physically Associated in a Complex

2001 • 211 citations

Membrane tethering in intracellular transport

1999 • 179 citations

A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1

1995 • 170 citations

beta sub2 -Adrenergic receptor internalization, endosomal sorting and plasma membrane recycling are regulated by Rab GTPases

2000 • 158 citations

Vps9p Is a Guanine Nucleotide Exchange Factor Involved in Vesicle-mediated Vacuolar Protein Transport

1999 • 135 citations

The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer

1999 • 127 citations

β2-Adrenergic Receptor Internalization, Endosomal Sorting, and Plasma Membrane Recycling Are Regulated by Rab GTPases

2000 • 123 citations

Protein binding and signaling properties of RIN1 suggest a unique effector function

1997 • 114 citations

Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

1991 • 107 citations

Molecular Cloning of a Novel Member of the Eukaryotic Polypeptide Chain-Releasing Factors (eRF)

1998 • 107 citations

Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion

1998 • 102 citations

RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans

1999 • 87 citations

The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer

1999 • 83 citations

Parallel Dimers and Anti-parallel Tetramers Formed by Epidermal Growth Factor Receptor Pathway Substrate Clone 15 (EPS15)

1997 • 76 citations

RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation

2001 • 63 citations

Eps15 Is Constitutively Oligomerized Due to Homophilic Interaction of Its Coiled-coil Region

1997 • 57 citations

A Novel Membrane-anchored Rab5 Interacting Protein Required for Homotypic Endosome Fusion

2000 • 51 citations

Association of Phosphatidylinositol 3-Kinase Composed of p110 -Catalytic and p85-Regulatory Subunits with the Small GTPase Rab5

2001 • 46 citations

Heat shock-regulated production of Escherichia coli beta-galactosidase in Saccharomyces cerevisiae.

1983 • 37 citations

Dimerization of small GTPase Rab5

2001 • 21 citations

[2] Purification of posttranslationally modified and unmodified Rab5 protein expressed in Spodoptera frugiperda cells

1995 • 20 citations