Rosiglitazone Inhibits Early Stage of Glucolipotoxicity-Induced Beta-Cell Apoptosis

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

2003 • 3,886 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

2003 • 2,089 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

1992 • 869 citations

Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity

2002 • 735 citations

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

2002 • 660 citations

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

2002 • 634 citations

Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death

2003 • 584 citations

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

1988 • 506 citations

Endothelial Cell Apoptosis: Biochemical Characteristics and Potential Implications for Atherosclerosis

2001 • 445 citations

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

2004 • 419 citations

β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats

2001 • 374 citations

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

1997 • 349 citations

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

1997 • 325 citations

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

1998 • 252 citations

Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

1999 • 238 citations

Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARγ₂ in the modulation of insulin secretion

2004 • 154 citations

[17] Structure and lipid binding properties of serum albumin

1986 • 136 citations

Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone

1996 • 125 citations

Low-dose dexamethasone in the rat: a model to study insulin resistance

2002 • 115 citations

Pioglitazone preserves pancreatic islet structure and insulin secretory function in three murine models of type 2 diabetes

2004 • 105 citations

Effect of Rosiglitazone Versus Insulin on the Pancreatic β-Cell Function of Subjects With Type 2 Diabetes

2004 • 95 citations

Troglitazone does not protect rat pancreatic β cells against free fatty acid-induced cytotoxicity

2002 • 43 citations

Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity

2005 • 42 citations

Role of TGF-β1 in the development of pancreatic fibrosis in Otsuka Long-Evans Tokushima Fatty rats

2002 • 39 citations

Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes

2000 • 25 citations

Chronic effects of different fatty acids and leptin in INS-1 cells

2001 • 23 citations

Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma

2002 • 22 citations