Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

1994 • 813 citations

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor

1997 • 655 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

Fatty acids, lipotoxicity and insulin secretion

1999 • 563 citations

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

1999 • 465 citations

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM

1997 • 465 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

1992 • 423 citations

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation.

1997 • 350 citations

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications

1995 • 269 citations

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

1998 • 252 citations

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

1997 • 217 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines

1992 • 216 citations

Dual Functional Role of Membrane Depolarization/Ca2+ Influx in Rat Pancreatic B-Cell

1992 • 180 citations

Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats

1988 • 157 citations

Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay

1992 • 151 citations

Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets.

1995 • 140 citations

Down regulation of peroxisome proliferator-activated receptorγ expression by inflammatory cytokines and its reversal by thiazolidinediones

1999 • 126 citations

Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in mice

1991 • 118 citations

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.

1999 • 115 citations

The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism.

1998 • 106 citations

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes

1999 • 97 citations

Augmentation of Insulin Release by Glucose in the Absence of Extracellular Ca2+: New Insights Into Stimulus-Secretion Coupling

1997 • 93 citations

Effects of a New Oral Hypoglycaemic Agent (CS‐045) on Metabolic Abnormalities and Insulin Resistance in Type 2 Diabetes

1994 • 89 citations

Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide

1995 • 78 citations

Effect of Troglitazone on B Cell Function, Insulin Sensitivity, and Glycemic Control in Subjects with Type 2 Diabetes Mellitus¹

1998 • 70 citations

Effect of Troglitazone on B Cell Function, Insulin Sensitivity, and Glycemic Control in Subjects with Type 2 Diabetes Mellitus

1998 • 49 citations

Dual functional role of membrane depolarization/Ca2+ influx in rat pancreatic B-cell

1992 • 44 citations

Palmitate and myristate selectively mimic the effect of glucose in augmenting insulin release in the absence of extracellular Ca2+.

1998 • 37 citations

Troglitazone (CS-045) Inhibits β-Cell Proliferation Rate Following Stimulation of Insulin Secretion in HIT-T 15 Cells

1998 • 34 citations

Pioglitazone hydrochloride stimulates insulin secretion in HIT-T 15 cells by inducing Ca2+ influx

1996 • 24 citations

Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling

1997 • 23 citations

Chronic effects of different fatty acids and leptin in INS-1 cells

2001 • 23 citations

Troglitazone but not pioglitazone affects ATP-sensitive K+ channel activity

1999 • 22 citations

Lack of effect of CS-045, a new antidiabetic agent, on insulin secretion in the remnant pancreas after 90% pancreatectomy in rats

1995 • 21 citations

Troglitazone (CS-045) Inhibits -Cell Proliferation Rate Following Stimulation of Insulin Secretion in HIT-T 15 Cells

1998 • 12 citations