Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

1963 • 2,254 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

1998 • 995 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

1992 • 869 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

1992 • 423 citations

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.

1996 • 378 citations

A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

1990 • 377 citations

Insulin secretion in diabetes mellitus

1981 • 364 citations

Evaluation of Glucose-6-Phosphate Dehydrogenase from Leuconostoc mesenteroides in the Hexokinase Method for Determining Glucose in Serum

1974 • 359 citations

β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion

1992 • 356 citations

The pancreatic islets in diabetes

1981 • 349 citations

Troglitazone action is independent of adipose tissue.

1997 • 340 citations

Disordered food intake and obesity in rats lacking cholecystokinin A receptors

1998 • 273 citations

Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic Agent

1983 • 266 citations

The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight

1999 • 255 citations

Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients

1996 • 239 citations

The isolation of insulin from a single cat pancreas

1962 • 209 citations

Effect of New Oral Antidiabetic Agent CS-045 on Glucose Tolerance and Insulin Secretion in Patients with NIDDM

1991 • 197 citations

Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat

1994 • 193 citations

Impaired Glucose Tolerance is Normalized by Treatment With the Thiazolidinedione Troglitazone

1997 • 143 citations

Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone

1996 • 125 citations

Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.

1999 • 103 citations

Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus?

1995 • 93 citations

Effects of a New Oral Hypoglycaemic Agent (CS‐045) on Metabolic Abnormalities and Insulin Resistance in Type 2 Diabetes

1994 • 89 citations

Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non—insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion?

1995 • 89 citations

Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK

1999 • 82 citations

Insulin Resistance in Skeletal Muscles in Patients With NIDDM

1992 • 73 citations

Impaired β-Cell Function and Deposition of Fat Droplets in the Pancreas as a Consequence of Hypertriglyceridemia in OLETF Rat, a Model of Spontaneous NIDDM

1997 • 73 citations

Exercise training has a long-lasting effect on prevention of non—insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima fatty rats

1996 • 58 citations

Pathogenesis of insulin resistance and hyperglycemia in non-insulin-dependent diabetes mellitus

1985 • 58 citations

Metabolic effects of troglitazone on fat-induced insulin resistance in the rat

1995 • 49 citations

Troglitazone prevents hyperglycemia-induced but not glucosamine-induced insulin resistance.

1998 • 45 citations

Lipoprotein compositional abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia.

1993 • 44 citations

Metabolic abnormalities in the genetically obese and diabetic Otsuka Long-Evans Tokushima fatty rat can be prevented and reversed by α-glucosidase inhibitor

1999 • 36 citations

Prophylaxis of genetically determined diabetes by diazoxide: a study in a rat model of naturally occurring obese diabetes.

1995 • 31 citations

Effects of obesity and inheritance on the development of non-insulin-dependent diabetes mellitus in Otsuka-Long-Evans-Tokushima Fatty rats

1995 • 31 citations

Apoptosis in the Pancreas of Genetically Diabetic Rats with a Disrupted Cholecystokinin (CCK-A) Receptor Gene

1997 • 11 citations

Effect of Timely Insulin Administration on Pancreatic B-Cells of Otsuka-Long-Evans-Tokushima-Fatty (OLETF) Strain Rats

1995 • 7 citations