Characterization of the IGF axis components in isolated rat hepatic stellate cells

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*

1980 • 752 citations

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

1991 • 680 citations

The Insulin-Like Growth Factors

1993 • 647 citations

Regulation of insulin-like growth factor I gene expression by growth hormone.

1986 • 558 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation

1976 • 399 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Evidence of Enzymatic Degradation of Insulin-Like Growth Factor-Binding Proteins in the 150K Complex during Pregnancy*

1990 • 349 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

Insulin-like growth factors and insulin: comparative aspects

1985 • 262 citations

Alveolar macrophages release an insulin-like growth factor I-type molecule.

1988 • 255 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.

1996 • 237 citations

Novel insights into the biology and physiology of the Ito cell

1995 • 181 citations

Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair.

1996 • 140 citations

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?

1987 • 123 citations

Insulinlike growth factor—ii/mannose 6-phosphate receptor is expressed on ccl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells

1995 • 121 citations

Acid-activated insulin-like growth factor-binding protein-3 proteolysis in normal and transformed cells. Role of cathepsin D.

1994 • 121 citations

Insulin-like growth factor binding protein (IGFBP) proteases: Functional regulators of cell growth

1995 • 117 citations

Transforming growth factor ?1-regulated gene expression of Ito cells

1996 • 116 citations

Production of Insulin-Like Growth Factor I and Its Binding Protein by Adult Rat Hepatocytes in Primary Culture*

1985 • 115 citations

Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.

1990 • 108 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Fails to Interact with G-proteins

1995 • 106 citations

Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts.

1984 • 104 citations

Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.

1995 • 99 citations

Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver.

1994 • 98 citations

Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: Regulation by insulin, insulinlike growth factor, and growth hormone

1996 • 95 citations

Human platelet-derived mitogens. II. Subcellular localization of insulinlike growth factor I to the alpha-granule and release in response to thrombin

1989 • 93 citations

Induction of glucokinase by insulin under the permissive action of dexamethasone in primary rat hepatocyte cultures

1979 • 84 citations

Coculture of primary rat hepatocytes and nonparenchymal cells permits expression of insulin-like growth factor binding protein-3 in vitro.

1994 • 80 citations

Heterogeneity of insulin‐like growth factor binding proteins between structure and affinity

1987 • 75 citations

Synthesis of insulinlike growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: Regulation by insulin, insulinlike growth factor, and growth hormone

1996 • 74 citations

Secretion of Insulin-Like Growth Factor-I and Binding Proteins by Rat Liver Fat-Storing Cells: Regulatory Role of Platelet-Derived Growth Factor*

1990 • 73 citations

The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts.

1996 • 72 citations

The expression of insulin-like growth factors and their binding proteins in normal human lymphocytes

1993 • 67 citations

The Differential Regulation by Glucagon and Growth Hormone of Insulin-Like Growth Factor (IGF)-I and IGF Binding Proteins in Cultured Rat Hepatocytes*

1991 • 64 citations

Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells

1995 • 63 citations

Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats.

1997 • 63 citations

Human platelet-derived mitogens. I. Identification of insulinlike growth factors I and II by purification and N alpha amino acid sequence analysis

1989 • 53 citations

Mediators of hepatic fibrogenesis.

1996 • 43 citations

Expression of Von Willebrand factor in normal and diseased rat livers and in cultivated liver cells

1995 • 41 citations

Metabolic actions of insulin-like growth factor-I in cultured hepatocytes from adult rats

1990 • 35 citations

Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells

1992 • 35 citations

Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid.

1994 • 34 citations

Origin of Lysosomal Proteins

1996 • 32 citations

Cellular localization and hormonal regulation of biosynthesis of insulin-like growth factor binding proteins and of the acid-labile subunit within rat liver

1995 • 29 citations

Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor

1992 • 28 citations

Distribution of messenger RNAs of insulin-like growth factor(IGF)-binding proteins-1 and -3 between parenchymal and nonparenchymal cells in rat liver.

1991 • 27 citations

Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding protein complex in primary cultures of human hepatocytes

1995 • 25 citations

Expression of Von Willebrand factor in normal and diseased rat livers and in cultivated liver cells*1

1995 • 22 citations

Hepatocyte-conditioned medium potentiates insulin-like growth factor (IGF) 1 and 2 stimulated DNA synthesis of cultured fat storing cells

1993 • 21 citations

Immunohistochemical localization of insulin-like growth factor binding protein-1, -3 and -4 in human fetal tissues and their analysis in media from fetal tissue explants.

1996 • 20 citations

The relation between hepatocellular damage and activation of fat-storing cell proliferation in vitro

1994 • 13 citations