Stress and Glucocorticoids in Aging

A Syndrome produced by Diverse Nocuous Agents

1936 • 3,733 citations

Handbook of the Psychology of Aging

2016 • 3,477 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1

1946 • 2,239 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Handbook of the Psychology of Aging

1986 • 1,567 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Handbook of the Biology of Aging

1978 • 871 citations

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

1986 • 773 citations

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

1984 • 729 citations

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

1968 • 700 citations

The Rate of Living.

1928 • 686 citations

Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications

1985 • 677 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*

1984 • 586 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

Pretreatment DST and Hypothalamic-Pituitary-Adrenocortical Function in Depressed Patients and Comparison Groups

1984 • 374 citations

TRANSCORTIN: A CORTICOSTEROID-BINDING PROTEIN OF PLASMA*†

1959 • 371 citations

Evolutionary Ecology of Marsupials

1985 • 357 citations

Glucocorticoid Inhibition of Glucose Uptake by Peripheral Tissues: Old and New Evidence, Molecular Mechanisms, and Physiological Significance

1971 • 347 citations

Progress in Psychoneuroendocrinology

1982 • 292 citations

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

1986 • 288 citations

The adrenocorticol stress-response in the aged male rat: Impairment of recovery from stress

1983 • 288 citations

Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

1908 • 256 citations

Cortisol Hypersecretion and Cognitive Impairment in Depression

1984 • 238 citations

Glucocorticoid toxicity in the hippocampus: in vitro demonstration

1988 • 219 citations

Treatment Development Strategies for Alzheimer’s Disease

1987 • 198 citations

Glucocorticoid toxicity in the hippocampus: Temporal aspects of neuronal vulnerability

1985 • 182 citations

Corticosteroid-Binding Globulin in the Rat: Studies on the Sex Difference

1965 • 172 citations

Chronic Dexamethasone Pretreatment Aggravates Ischemic Neuronal Necrosis

1986 • 172 citations

Age pigments, cell loss and hippocampal function

1979 • 170 citations

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 • 162 citations

Elevated Corticosterone Levels

1984 • 154 citations

Glucocorticoid Toxicity in the Hippocampus

1986 • 152 citations

The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition

1986 • 149 citations

HISTOLOGICAL CHANGES IN THE ORGANS AND TISSUES OF MIGRATING AND SPAWNING PACIFIC SALMON (GENUS ONCORHYNCHUS)¹

1960 • 146 citations

Effect of age and sex on cortisol secretion in depressives and normals

1984 • 130 citations

Chronic Stress Effects on Adrenocortical Responsiveness in Young and Aged Rats

1973 • 130 citations

Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections

1981 • 125 citations

Stress and population regulation in small mammals.

1985 • 125 citations

Endocrine changes in dasyurid marsupials with differing mortality patterns

1981 • 118 citations

Adrenocortical hormones, ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11-deoxycorticosterone, total and free cortisol and urinary corticosteroids

1983 • 110 citations

The dexamethasone suppression test in an elderly population.

1981 • 109 citations

ADRKNOCORTICAL FUNCTION AND CORTISOL METABOLISM IN OLD AGE*

1961 • 108 citations

Diminished Diurnal Secretion of Adrenocorticotropin (ACTH), But Not Corticosterone, in Old Male Rats: Possible Relation to Increased Adrenal Sensitivity to ACTHin Vivo*

1987 • 105 citations

Failure of glucocorticoid feedback in males of a population of small marsupials (Antechinus swainsonii) during the period of mating

1986 • 103 citations

Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4

1986 • 99 citations

Vulnerability to Stress-Induced Tumor Growth Increases with Age in Rats: Role of Glucocorticoids*

1985 • 98 citations

Plasma Corticosteroids: Changes in Concentration after Stimulation of Hippocampus and Amygdala

1963 • 97 citations

Hypothalamus Pituitary and Aging

1977 • 94 citations

Morphologische Ver�nderungen im Diencephalon und Telencephalon nach St�rungen des Regelkreises Adenohypophyse-Nebennierenrinde

1968 • 91 citations

PROLONGATION OF THE LIFE SPAN OF KOKANEE SALMON (ONCORHYNCHUS NERKA KENNERLYI) BY CASTRATION BEFORE BEGINNING OF GONAD DEVELOPMENT

1961 • 90 citations

Adrenocortical Responsiveness to Stress and ACTH in Aging Rats

1970 • 86 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

Influence of age on the cortisol response to dexamethasone

1984 • 79 citations

Chronic and Acute Dexamethasone Suppression of Stress Activation of the Adrenal Cortex in Young and Aged Rats

1972 • 75 citations

The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats

1983 • 72 citations

Adrenocortical Responsiveness to Graded ACTH Infusions in Normal Young and Elderly Human Subjects

1986 • 70 citations

SERUM CORTICOTROPHIN, PLASMA CORTISOL AND URINARY EXCRETION OF 17-KETOGENIC STEROIDS IN THE ELDERLY (AGE GROUP: 66–94 YEARS)

1971 • 62 citations

Recovery of stress-induced increases in noradrenaline turnover is delayed in specific brain regions of old rats

1984 • 58 citations

Pituitary Degeneration and Adrenal Tissue Hyperplasia in Spawning Pacific Salmon

1957 • 55 citations

Do vasopressin-related peptides induce hippocampal corticosterone receptors? Implications for aging

1984 • 54 citations

Aging of the Rat Adrenocortical Cell: Response to Acth and Cyclic Amp in Vitro

1983 • 49 citations

Differential Effects of Aging on Adrenocdrticotropin Receptors, Adenosine 3′5′-Monophosphate Response, and Corticosterone Secretion in Adrenocortical Cells from Sprague-Dawley Rats*

1986 • 49 citations

The development of sex differences in the adrenal morphology and responsiveness in stress of rats from birth to the end of life

1976 • 47 citations

law of deviation of homeostasis and diseases of aging

1981 • 45 citations

Effects of chronic ACTH stimulation on adrenocortical function in young and aged rats

1972 • 44 citations

Serum Insulin Changes in Male Rats Associated With Age and Reproductive Activity

1974 • 43 citations

Reduced Ability of Old Male Rats to Release Acth and Corticosterone in Response to CRF Administration

1984 • 43 citations

Dexamethasone suppression test: experimental model in rats, and effect of age.

1984 • 41 citations

Bidirectional responsiveness of the pituitary-adrenal system in old and young male and female rats

1986 • 38 citations

Urinary-Free Cortisol Excretion in Relation to Age in Acutely Stressed Persons with Depressive Symptoms

1984 • 38 citations

Biochemical indices of reactivity and habituation in rats with hippocampal lesions

1984 • 35 citations

Cushing's syndrome.

1982 • 32 citations

Hypothalamic-pituitary-adrenal axis activity and age in major depression.

1984 • 30 citations

Occurrence of high concentrations of postdexamethasone cortisol in elderly psychiatric inpatients

1985 • 27 citations

Pituitary Function in the Elderly

1970 • 26 citations

The Influence of Age on Steroidogenic Enzyme Activities of the Rat Adrenal Gland: Enhanced Expression of Cholesterol Side-Chain Cleavage Activity*

1987 • 23 citations

Hypothalamic - Pituitary - Adrenocortical Function in Geriatric Depression: Diagnostic and Treatment implications

1985 • 22 citations

Metabolism of Progesterone-4-C¹⁴in Young and Elderly Men

1963 • 22 citations

Réactivité au ‘stress’ et capacité d’adaptation à une situation inhabituelle chez le rat jeune, adulte et âgé

1964 • 22 citations

Aging and adrenal cortical hormones.

1952 • 21 citations

Regulation of Corticosterone Levels and Liver Enzyme Activity in Aging Rats

1975 • 20 citations

Interaction of Aging with <i>in vitro </i>Adrenocortical Responsiveness to ACTH and Cyclic AMP

1979 • 19 citations

Diurnal Variation of the Serum Cortisol Level of Geriatric Subjects

1971 • 18 citations

AGE DEPENDENCE OF PLASMA OESTROGEN RESPONSE TO HCG AND ACTH IN MEN

1975 • 18 citations

The miscible pool and turnover rate of cortisol in the aged, and variations in relation to time of day

1969 • 11 citations

ADRENOCORTICAL FUNCTION IN THE AGED, ASSESSED BY THE RAPID CORTICOTROPHIN TEST (SYNACTHEN®)

1970 • 5 citations

Acth Administration, Adrenal Response and Age

1954 • 3 citations