The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Adrenal steroid receptors and actions in the nervous system

1986 • 1,231 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period

1986 • 968 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

The Physiology and Pathology of Exposure to Stress

1951 • 783 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

1984 • 729 citations

Regulation of ACTH Secretion: Variations on a Theme of B

1987 • 668 citations

Infantile Experience and Resistance to Physiological Stress

1957 • 656 citations

Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*

1984 • 586 citations

In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*

1982 • 557 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation

1989 • 473 citations

Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat

1989 • 470 citations

Mediation by Corticotropin Releasing Factor (CRF) of Adenohypophysial Hormone Secretion

1986 • 443 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

Endocrinology and Metabolism.

1988 • 376 citations

Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications

1987 • 375 citations

Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis

1986 • 319 citations

The adrenocorticol stress-response in the aged male rat: Impairment of recovery from stress

1983 • 288 citations

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

2013 • 287 citations

Simple Method of Harvesting Limnoria from Nature

1962 • 280 citations

Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

1985 • 264 citations

Hemorrhage-Induced Secretion of Corticotropin-Releasing Factor-Like Immunoreactivity into the Rat Hypophysial Portal Circulation and Its Inhibition by Glucocorticoids*

1984 • 260 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

Differential Response of Type I and Type II Corticosteroid Receptors to Changes in Plasma Steroid Level and Circadian Rhythmicity

1987 • 247 citations

Corticosteroid Feedback Control of ACTH Secretion: Effect of Stress-Induced Corticosterone Secretion on Subsequent Stress Responses in the Rat1

1973 • 237 citations

The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters

1985 • 232 citations

The development of the glucocorticoid receptor system in the rat limbic brain. I. Ontogeny and autoregulation

1985 • 214 citations

Specificity of the Adrenal Steroid Receptor System in Rat Hippocampus*

1982 • 213 citations

Postweaning Development of Negative Feedback in the Pituitary-Adrenal System of the Rat

1973 • 200 citations

Basal ACTH, Corticosterone and Corticosterone-Binding Globulin Levels over the Diurnal Cycle, and Age-Related Changes in Hippocampal Type I and Type II Corticosteroid Receptor Binding Capacity in Young and Aged, Handled and Nonhandled Rats

1992 • 200 citations

A molecular framework for the actions of glucocorticoid hormones in the nervous system

1989 • 193 citations

Participation of the Dorsal Hippocampus in the Glucocorticoid Feedback Effect on Adrenocortical Activity

1980 • 190 citations

Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

1986 • 188 citations

Characterization of Rat Brain Aldosterone Receptors Reveals High Affinity for Corticosterone

1983 • 188 citations

Modification of the corticosterone response curve as a function of handling in infancy

1969 • 163 citations

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 • 162 citations

Regulation of Glucocorticoid Receptors in Brain by Corticosterone Treatment of Adrenalectomized Rats

1982 • 159 citations

The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation

1985 • 158 citations

Elevated Corticosterone Levels

1984 • 154 citations

Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures

1990 • 153 citations

Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors

1988 • 150 citations

The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition

1986 • 149 citations

Thyroid Hormones Influence the Development of Hippocampal Glucocorticoid Receptors in the Rat: A Mechanism for the Effects of Postnatal Handling on the Development of the Adrenocortical Stress Response

1987 • 147 citations

Effects of early experience on adrenocortical reactivity

1969 • 144 citations

The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat

1985 • 142 citations

Adrenocortical Steroids and the Brain

1987 • 141 citations

The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus

1990 • 138 citations

Glucocorticoids and Hippocampus: Receptors in Search of a Function

1982 • 124 citations

Differential ontogeny of Type 1 and Type 2 benzodiazepine receptors

1981 • 122 citations

Further studies of brain aldosterone binding sites employing new mineralocorticoid and glucocorticoid receptor markers in vitro

1985 • 122 citations

The development of the glucocorticoid receptor system in the rat limbic brain. II. An autoradiographic study

1985 • 120 citations

Increased Pituitary Sensitivity to Glucocorticoid Feedback during the Stress Nonresponsive Period in the Neonatal Rat*

1986 • 120 citations

Inhibition of Immunoreactive Corticotropin-Releasing Factor Secretion into the Hypophysial-Portal Circulation by Delayed Glucocorticoid Feedback*

1986 • 118 citations

Selectivity of serotonergic drugs for multiple brain serotonin receptors

1987 • 117 citations

Diminished Diurnal Secretion of Adrenocorticotropin (ACTH), But Not Corticosterone, in Old Male Rats: Possible Relation to Increased Adrenal Sensitivity to ACTHin Vivo*

1987 • 105 citations

Ontogeny of Type I and Type II corticosteroid receptors in the rat hippocampus

1988 • 104 citations

Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain

1987 • 96 citations

Neurotrophic ACTH analogue promotes plasticity of type I corticosteroid receptor in brain of senescent male rats

1988 • 95 citations

Glucocorticoid binding to receptor-like proteins in rat brain and pituitary: Ontogenetic and experimentally induced changes

1976 • 94 citations

Differential fornix ablations and the circadian rhythmicity of adrenal corticosteroid secretion

1980 • 86 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors

1988 • 83 citations

Hippocampal inhibition of pituitary-adrenocortical function in female rats

1980 • 81 citations

Mineralcorticoid Receptor in Rat Kidney and Hippocampus: Characterization and Quantitation by Isoelectric Focusing

1983 • 81 citations

Effect of angiotensin II on ACTH release in vivo: role of corticotropin-releasing factor

1983 • 75 citations

Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: Direct binding studies

1987 • 73 citations

The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats

1983 • 72 citations

Administration of dexamethasone prior to training blocks ACTH-induced recovery of an extinguished avoidance response.

1985 • 67 citations

Observations on cell growth and regulation of glutamine synthetase by dexamethasone in primary cultures of forebrain and cerebellar astrocytes

1985 • 67 citations

Ontogenesis of Glucocorticoid Receptors in Anterior Pituitary Gland: Transient Dissociation among Cytoplasmic Receptor Density, Nuclear Uptake, and Regulation of Corticotropic Activity*

1981 • 63 citations

Handling in Infancy: Increased Levels of the Hypothalamic Corticotropin Releasing Factor (CRF) Following Exposure to a Novel Situation

1972 • 60 citations

The ontogeny of corticosterone and dexamethasone receptors in rat brain

1977 • 56 citations

Age-related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary

1991 • 52 citations

Ontogenetical Variations of Transcortin Modulate Glucocorticoid Receptor Function and Corticotropic Activity in the Pituitary Gland

1983 • 47 citations

The development of sex differences in the adrenal morphology and responsiveness in stress of rats from birth to the end of life

1976 • 47 citations

Hormonal Correlates of Behavior

1975 • 44 citations

Early Experience and Hormones: Emotional Behavior and Adrenocortical Function

1975 • 42 citations

Glucocorticoid receptors in brain and pituitary of the lactating rat

1989 • 39 citations

Bidirectional responsiveness of the pituitary-adrenal system in old and young male and female rats

1986 • 38 citations

Protein-Bound Corticosteroid in Human Serum Is Selectively Transported into Rat Brain and Liver in Vivo*

1983 • 37 citations

Feedback Effects of Dexamethasone on Adrenocortical Responses in Rats with Fornix Section

1976 • 37 citations

Physical stimulation reduces the body temperature of infant rats

1988 • 32 citations

Feedback Actions of Adrenal Steroid Hormones

1982 • 22 citations

Réactivité au ‘stress’ et capacité d’adaptation à une situation inhabituelle chez le rat jeune, adulte et âgé

1964 • 22 citations

Effects of early experience on the metabolism and production of corticosterone in rats

1976 • 18 citations

DIVISION OF PSYCHOLOGY: INFANTILE HANDLING AND BODY TEMPERATURE CHANGE IN THE RAT. I. INITIAL INVESTIGATIONS OF THE TEMPERATURE HYPOTHESIS*

1968 • 10 citations

DIVISION OF PSYCHOLOGY: INFANTILE HANDLING AND BODY TEMPERATURE CHANGE IN THE RAT. II. PARAMETRIC INVESTIGATIONS OF BODY TEMPERATURE LOSS AND THEORETICAL IMPLICATIONS*

1968 • 10 citations

Regulation of Stress‐induced Secretion of POMC‐derived Peptidesa

1987 • 10 citations