Abnormal Heart Rate Regulation in GIRK4 Knockout Mice

On the use of windows for harmonic analysis with the discrete Fourier transform

1978 • 6,860 citations

Power Spectrum Analysis of Heart Rate Fluctuation: A Quantitative Probe of Beat-to-Beat Cardiovascular Control

1981 • 4,922 citations

Decreased heart rate variability and its association with increased mortality after acute myocardial infarction

1987 • 3,955 citations

Frequency domain measures of heart period variability and mortality after myocardial infarction.

1992 • 1,702 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Defective Cardiac Parasympathetic Control in Patients with Heart Disease

1971 • 971 citations

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

1991 • 832 citations

The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

1995 • 830 citations

Über humorale übertragbarkeit der Herznervenwirkung

1921 • 817 citations

Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino‐atrial node cells.

1988 • 780 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis

1988 • 726 citations

Transfer function analysis of the circulation: unique insights into cardiovascular regulation

1991 • 725 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel

1993 • 600 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Transfer function analysis of autonomic regulation. I. Canine atrial rate response

1989 • 495 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1924 • 473 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

IRK(1–3) and GIRK(1–4) Inwardly Rectifying K⁺Channel mRNAs Are Differentially Expressed in the Adult Rat Brain

1996 • 450 citations

Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

1994 • 450 citations

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

1995 • 441 citations

Ion channel regulation by G proteins

1995 • 408 citations

Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities.

1979 • 381 citations

Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia.

1983 • 370 citations

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

1993 • 355 citations

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K ⁺ channel GIRK2

1997 • 336 citations

Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

1995 • 324 citations

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

1995 • 304 citations

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.

1996 • 302 citations

Cloning provides evidence for a family of inward rectifier and G‐protein coupled K⁺ channels in the brain

1994 • 280 citations

Muscarinic Modulation of Cardiac Rate at Low Acetylcholine Concentrations

1989 • 277 citations

Respiratory sinus arrhythmia in the denervated human heart

1989 • 272 citations

Delayed Mammary Tumor Progression in Muc-1 Null Mice

1995 • 268 citations

Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac G _sα Overexpression

1996 • 266 citations

Cardiac autonomic neuropathy in diabetes: Comparison of measures of R-R interval variation

1981 • 261 citations

Changes in membrane currents in bullfrog atrium produced by acetylcholine.

1976 • 259 citations

Baroreflex sensitivity and electrophysiological correlates in patients after acute myocardial infarction.

1991 • 246 citations

Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation

1991 • 231 citations

Gβγ Binds Directly to the G Protein-gated K+ Channel, IKACh

1995 • 227 citations

Developmental Changes in Ionic Channel Activity in the Embryonic Murine Heart

1996 • 209 citations

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice.

1996 • 205 citations

Relaxation of the ACh-induced potassium current in the rabbit sinoatrial node cell

1978 • 200 citations

Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease

1997 • 199 citations

Cloning and functional expression of a rat heart KATP channel

1994 • 184 citations

Cloning of a Xenopus laevis Inwardly Rectifying K+ Channel Subunit That Permits GIRK1 Expression of IKACh Currents in Oocytes

1996 • 176 citations

Inhibition of the hyperpolarization‐activated current (if) induced by acetylcholine in rabbit sino‐atrial node myocytes.

1988 • 166 citations

Molecular Cloning of a Mouse G-Protein-Activated K+ Channel (mGIRK1) and Distinct Distributions of 3 GIRK (GIRK1, 2 and 3) mRNAs in Mouse Brain

1995 • 161 citations

Heterologous Multimeric Assembly Is Essential for K+ Channel Activity of Neuronal and Cardiac G-Protein-Activated Inward Rectifiers

1995 • 153 citations

A sustained inward current activated at the diastolic potential range in rabbit sino‐atrial node cells.

1995 • 135 citations

Does the ?pacemaker current? generate the diastolic depolarization in the rabbit SA node cells?

1983 • 132 citations

Effect of adenosine on atrioventricular conduction. I: Site and characterization of adenosine action in the guinea pig atrioventricular node.

1986 • 124 citations

Adenosine receptors in frog sinus venosus: slow inhibitory potentials produced by adenine compounds and acetylcholine.

1979 • 118 citations

Gβγ Directly Binds to the Carboxyl Terminus of the G Protein-Gated Muscarinic K+ Channel, GIRK1

1995 • 95 citations

The K⁺ channel inward rectifier subunits form a channel similar to neuronal G protein‐gated K⁺ channel

1996 • 91 citations

The action of acetylcholine on background conductance in frog atrial trabeculae.

1978 • 91 citations

The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current

1995 • 89 citations

G protein activation of cardiac muscarinic K+ channels

1992 • 85 citations

An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain

1997 • 85 citations

Distribution and localization of a G protein‐coupled inwardly rectifying K⁺ channel in the rat

1994 • 84 citations

Pancreatic Islet Cells Express a Family of Inwardly Rectifying K+ Channel Subunits Which Interact to Form G-protein-activated Channels

1995 • 78 citations

Decreased heart rate variability in transgenic mice overexpressing atrial beta 1-adrenoceptors

1996 • 78 citations

Transmission at autonomic neuroeffector junctions

1992 • 73 citations

Molecular basis of cardiac potassium channel stimulation by protein kinase A.

1994 • 72 citations

Effects of selective A1 and A2 adenosine receptor agonists on cardiovascular tissues

1993 • 70 citations

The power spectral analysis of heart rate variability in athletes during dynamic exercise—Part I

1995 • 64 citations

A Novel Ubiquitously Distributed Isoform of GIRK2 (GIRK2B) Enhances GIRK1 Expression of the G-Protein-Gated K+ Current inXenopusOocytes

1996 • 61 citations

The Cardiac Inward Rectifier K+ Channel Subunit, CIR, Does Not Comprise the ATP-sensitive K+ Channel, IKATP

1995 • 55 citations

Targeted inactivation of α_i2or α_i3disrupts activation of the cardiac muscarinic K⁺channel, I_K^+Ach, in intact cells

1997 • 53 citations

Ionic Mechanisms of the Cardiac Pacemaker Potential.

1996 • 51 citations

The effects of triiodothyronine (T₃) on heart rate, temperature and ECG measured with telemetry in freely moving mice

1997 • 49 citations

Specific atrial overexpression of G protein coupled human 1 adrenoceptors in transgenic mice

1993 • 44 citations

The telemetric monitoring of heart rate, locomotor activity, and body temperature in mice and voles (Microtus arvalis) during ambient temperature changes

1996 • 41 citations

The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current

1995 • 39 citations

Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells

1989 • 37 citations

Effects of vagal stimulation and applied acetylcholine on the arrested sinus venosus of the toad.

1990 • 34 citations

Delayed rectifier potassium channels in ventricle and sinoatrial node of the guinea pig: Molecular and regulatory properties

1993 • 32 citations

Calcitonin-gene-related peptide activates the muscarinic-gated K+ current in atrial cells

1991 • 30 citations

Partial Structure, Chromosome Localization, and Expression of the MouseIclnGene

1997 • 26 citations

Localization of a G-protein-coupled inwardly rectifying K+ channel, CIR, in the rat brain

1997 • 26 citations

Cardiac and autonomic system reactions to stretch of the atria

1975 • 25 citations

Cardiac pacemaker: 15 years of "new" interpretation.

1995 • 25 citations

Partial Structure, Chromosome Localization, and Expression of the MouseGirk4Gene

1997 • 22 citations

Phenotypic determinants of heart rate variability in cardiac hypertrophy and failure

1994 • 11 citations