The Crisis in Antibiotic Resistance

The life and times of the Enterococcus

1990 • 1,772 citations

Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus Faecium

1988 • 1,441 citations

Enterobacter Bacteremia: Clinical Features and Emergence of Antibiotic Resistance during Therapy

1991 • 884 citations

Pneumococcal resistance to antibiotics

1990 • 820 citations

Extended-spectrum beta-lactamases

1989 • 808 citations

More extended-spectrum beta-lactamases

1991 • 740 citations

Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA

1991 • 640 citations

Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification

1991 • 605 citations

Antimicrobial resistance of Staphylococcus aureus: genetic basis

1987 • 596 citations

Emergence of Vancomycin Resistance in Coagulase-Negative Staphylococci

1987 • 594 citations

Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.

1980 • 584 citations

Deciding who gets what.

1983 • 561 citations

Intercontinental Spread of a Multiresistant Clone of Serotype 23F Streptococcus pneumoniae

1991 • 424 citations

Methicillin-Resistant Staphylococcal Colonization and Infection in a Long-Term Care Facility

1991 • 389 citations

Resistance to Erythromycin in Group A Streptococci

1992 • 361 citations

Rapid Development of Ciprofloxacin Resistance in Methicillin-Susceptible and -Resistant Staphylococcus aureus

1991 • 320 citations

Transferable vancomycin and teicoplanin resistance in Enterococcus faecium

1989 • 315 citations

Horizontal transfer of multiple penicillin‐binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae

1991 • 315 citations

Antimicrobial resistance among respiratory isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in the United States

1990 • 308 citations

High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant

1986 • 293 citations

Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates Causing Systematic Infections in Spain, 1979-1989

1990 • 292 citations

Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin‐resistant clinical isolates of Streptococcus pneumoniae

1991 • 280 citations

Nosocomial Infection by Gentamicin-ResistantStreptococcus faecalis

1987 • 273 citations

Antimicrobial Resistance of Streptococcus pneumoniae in the United States, 1979-1987

1991 • 269 citations

Extremely High Incidence of Antibiotic Resistance in Clinical Isolates of Streptococcus pneumoniae in Hungary

1991 • 266 citations

Methicillin-resistant staphylococci

1988 • 266 citations

A Cluster of Vancomycin-Resistant Enterococcus faecium in an Intensive Care Unit

1992 • 261 citations

Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis.

1983 • 256 citations

Occurrence of a beta-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci

1985 • 252 citations

Resistance to vancomycin and teicoplanin: an emerging clinical problem

1990 • 235 citations

Antibiotic susceptibilities and drug resistance in Moraxella (Branhamella) catarrhalis

1990 • 231 citations

Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity

1991 • 223 citations

Penicillin-Binding Proteins of Gram-Negative Bacteria

1988 • 212 citations

Quinolone Antimicrobial Agents

1992 • 207 citations

Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256

1989 • 198 citations

Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae

1989 • 197 citations

Methicillin-Resistant Staphylococcus aureus

1989 • 195 citations

Resistance of enterococci to glycopeptides

1990 • 193 citations

World-wide development of antibiotic resistance in pneumococci

1987 • 188 citations

Development of resistance during antibiotic therapy

1987 • 179 citations

Inducible -Lactamases: Clinical and Epidemiologic Implications for Use of Newer Cephalosporins

1988 • 177 citations

Klebsiella pneumoniae and Other Enterobacteriaceae Producing Novel Plasmid-Mediated -Lactamases Markedly Active Against Third-Generation Cephalosporins: Epidemiologic Studies

1988 • 169 citations

Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus

1989 • 168 citations

Antibiotic-Resistant Streptococcus pneumoniae: Clinical and Epidemiologic Aspects

1981 • 156 citations

Sensitivity of Group A Streptococci to Antibiotics

1979 • 151 citations

A Cluster of Vancomycin-Resistant Enterococcus faecium in an Intensive Care Unit

1992 • 148 citations

Survey of methicillin-resistant clinical strains of coagulase-negative staphylococci for mecA gene distribution

1992 • 148 citations

Inducible Resistance to Vancomycin in Enterococcus faecium D366

1989 • 147 citations

Emergence of Antibiotic Resistance In Hospitals, 1935-1975

1979 • 144 citations

β-Lactam Antibiotics: Structural Relationships Affecting in Vitro Activity and Pharmacologic Properties

1986 • 142 citations

The VANA glycopeptide resistance protein is related to d-alanyl-d-alanine ligase cell wall biosynthesis enzymes

1990 • 141 citations

Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem

1991 • 137 citations

Resistance to cefotaxime and seven other beta-lactams in members of the family Enterobacteriaceae: a 3-year survey in France

1992 • 136 citations

Evidence for natural gene transfer from gram-positive cocci to Escherichia coli

1988 • 135 citations

Origin and evolution of genes specifying resistance to macrolide, lincosamide and streptogramin antibiotics: data and hypotheses

1987 • 133 citations

Binding of -Lactam Antibiotics to Penicillin-Binding Proteins in Methicillin-Resistant Staphylococcus aureus

1990 • 131 citations

Epidemiology and pathogenesis of systemic fungal infections in the immunocompromised host

1991 • 129 citations

Burn Units as a Source of Methicillin-Resistant

1983 • 123 citations

Penicillin-Binding Proteins and the Antibacterial Effectiveness of β-Lactam Antibiotics

1986 • 119 citations

Resistance of Bacteria to Antibacterial Agents: Report of Task Force 2

1987 • 117 citations

Infections Caused by Pseudomonas maltophilia

1987 • 114 citations

BRO beta-lactamases of Branhamella catarrhalis and Moraxella subgenus Moraxella, including evidence for chromosomal beta-lactamase transfer by conjugation in B. catarrhalis, M. nonliquefaciens, and M. lacunata

1989 • 112 citations

Infections Due to Beta-Lactamase-producing, High-Level Gentamicin-resistant Enterococcus faecalis

1992 • 106 citations

Characterization of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis

1989 • 104 citations

High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium

1988 • 102 citations

Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins

1991 • 97 citations

R-plasmid-encoded adhesive factor in Klebsiella pneumoniae strains responsible for human nosocomial infections

1992 • 96 citations

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases

1991 • 96 citations

Five independent combinations of mutations can result in low-affinity penicillin-binding protein 2x of Streptococcus pneumoniae

1991 • 93 citations

Resistance to Imipenem Among Selected Gram-Negative Bacilli in the United States

1992 • 92 citations

Coagulase-negative staphylococci resistant to beta-lactam antibiotics in vivo produce penicillin-binding protein 2a

1987 • 91 citations

Risk Factors for Epidemic Xanthomonas Maltophilia Infection/Colonization in Intensive Care Unit Patients

1992 • 87 citations

Distribution and resistance patterns ofHaemophilus influenzae: A European cooperative study

1988 • 87 citations

Epidemiology of Penicillinase-ProducingNeisseria gonorrhoeaeInfections

1982 • 83 citations

General mechanisms of resistance to antibiotics

1988 • 76 citations

Antigenic Variation of Penicillin-Binding Proteins from Penicillin-Resistant Clinical Strains of Streptococcus pneumoniae

1991 • 73 citations

Cloning and expression of methicillin resistance from Staphylococcus epidermidis in Staphylococcus carnosus

1988 • 70 citations

Enterococci from Bangkok, Thailand, with high-level resistance to currently available aminoglycosides

1983 • 70 citations

Molecular Epidemiology of Antibiotic Resistance Plasmids of Haemophilus Species and Neisseria gonorrhoeae

1986 • 68 citations

The emergence of erythromycin resistance in Streptococcus pyogenes in Fremantle, Western Australia

1989 • 66 citations

The lethal action of aminoglycoside

1988 • 65 citations

The antimicrobial activity of mupirocin—an update on resistance

1991 • 59 citations

Gentamicin Resistance Plasmids of Enterococci from Diverse Geographic Areas Are Heterogeneous

1988 • 58 citations

Current mechanisms of resistance to antimicrobial agents in microorganisms causing infection in the patient at risk for infection

1984 • 57 citations

Presence of an additional penicillin-binding protein in methicillin-resistant Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, and Staphylococcus simulans with a low affinity for methicillin, cephalothin, and cefamandole

1990 • 56 citations

Outbreaks of Infections with Erythromycin-resistant Group A Streptococci in Child Day Care Centres

1990 • 53 citations

Bacterial resistance to antibiotics as a function of outer membrane permeability

1988 • 51 citations

Risk Factors for Epidemic Xanthomonas maltophilia Infection/Colonization in Intensive Care Unit Patients

1992 • 48 citations

Epidemiology of Rob -Lactamase Among Ampicillin-Resistant Haemophilus influenzae Isolates in the United States

1988 • 45 citations

Evolution of antimicrobial resistance and nosocomial infection

1981 • 45 citations

gyrA Mutations in Ciprofloxacin-Resistant, Methicillin-Resistant Staphylococcus aureus from Indiana, Minnesota, and Tennessee

1991 • 37 citations

Persistence mechanisms in Pseudomonas aeruginosa from cystic fibrosis patients undergoing ciprofloxacin therapy

1991 • 36 citations

The renaissance of erythromycin

1986 • 36 citations

Synergy of ciprofloxacin with fosfomycin in vitro against Pseudomonas isolates from patients with cystic fibrosis

1988 • 33 citations

Origin of small beta-lactamase-specifying plasmids in Haemophilus species and Neisseria gonorrhoeae

1986 • 31 citations

Variability of Penicillin-Binding Proteins from Penicillin-Sensitive Streptococcus pneumoniae

1991 • 30 citations

Erythromycin-resistant Beta-hemolytic Streptococci Group A in Goteborg, Sweden

1988 • 28 citations

Methicillin-resistant staphylococci

1990 • 27 citations

Coagulase-Negative Staphylococci

1989 • 27 citations

Perspectives of beta-lactamases inhibitors in therapy of infections caused by Escherichia coli or Klebsiella with plasmidic resistance to third generation cephalosporins

1990 • 23 citations

Enoxacin-induced modification of the susceptibility of bacteria to phagocytic killing

1988 • 14 citations

Patterns of resistance and resistance mechanisms in anaerobes

1992 • 9 citations

Efficacy of spiramycin on experimental airborne legionellosis in guinea

1988 • 8 citations

Uptake of ³H-norfloxacin in methicillin-resistant Staphylococcus aureus

1991 • 8 citations

Penicillin-Binding Proteins inStreptococcus pneumoniae:Alterations during Development of Intrinsic Penicillin Resistance

1991 • 4 citations