Parasite genomics: current status and future prospects

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum

2000 • 545 citations

The TIGR Gene Indices: analysis of gene transcript sequences in highly sampled eukaryotic species

2001 • 463 citations

Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum

1998 • 455 citations

Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum

1999 • 334 citations

The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

1999 • 322 citations

Protection against mycoplasma infection using expression-library immunization

1995 • 296 citations

Inflammatory Responses Induced by the Filarial Nematode Brugia malayi Are Mediated by Lipopolysaccharide-like Activity from Endosymbiotic Wolbachia Bacteria

2000 • 248 citations

Leishmania majorFriedlin chromosome 1 has an unusual distribution of protein-coding genes

1999 • 234 citations

Shotgun DNA microarrays and stage‐specific gene expression in Plasmodium falciparum malaria

2000 • 214 citations

Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor

1998 • 205 citations

Gene Discovery by EST Sequencing inToxoplasma gondiiReveals Sequences Restricted to the Apicomplexa

1998 • 182 citations

The Giardia lamblia genome

2000 • 179 citations

TheGiardiagenome project database

2000 • 168 citations

Identification oftgh-2, a Filarial Nematode Homolog ofCaenorhabditis elegans daf-7and Human Transforming Growth Factor β, Expressed in Microfilarial and Adult Stages ofBrugia malayi

2000 • 158 citations

Co‐ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis

2001 • 153 citations

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen

2001 • 149 citations

A Novel Serpin Expressed by Blood-Borne Microfilariae of the Parasitic Nematode Brugia malayi Inhibits Human Neutrophil Serine Proteinases

1999 • 118 citations

Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice

1998 • 117 citations

Genes expressed in Brugia malayi infective third stage larvae

1996 • 110 citations

The African trypanosome genome

2000 • 110 citations

Identification of Vaccine Candidates for Experimental Visceral Leishmaniasis by Immunization with Sequential Fractions of a cDNA Expression Library

2000 • 101 citations

PlasmoDB: An integrative database of the Plasmodium falciparum genome. Tools for accessing and analyzing finished and unfinished sequence data

2001 • 99 citations

Targeting of Wolbachia endobacteria in Litomosoides sigmodontis: comparison of tetracyclines with chloramphenicol, macrolides and ciprofloxacin

2000 • 99 citations

A Novel Member of the Transforming Growth Factor-β (TGF-β) Superfamily from the Filarial NematodesBrugia malayiandB. pahangi

1998 • 95 citations

The filarial genome project: analysis of the nuclear, mitochondrial and endosymbiont genomes of Brugia malayi

2000 • 95 citations

Identification of Potential Vaccine and Drug Target Candidates by Expressed Sequence Tag Analysis and Immunoscreening ofOnchocerca volvulusLarval cDNA Libraries

2000 • 94 citations

Amastigote Surface Proteins ofTrypanosoma cruziAre Targets for CD8+ CTL

1998 • 93 citations

Tetracycline Inhibits Development of the Infective-Stage Larvae of Filarial Nematodes in Vitro

2000 • 90 citations

Preliminary profile of the Cryptosporidium parvum genome: an expressed sequence tag and genome survey sequence analysis

2000 • 83 citations

Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against LethalTrypanosoma cruziInfection

1998 • 82 citations

The Trypanosoma cruzi Mucin Family Is Transcribed from Hundreds of Genes Having Hypervariable Regions

1998 • 76 citations

DNA-Based Immunization withTrypanosoma cruziComplement Regulatory Protein Elicits Complement Lytic Antibodies and Confers Protection againstTrypanosoma cruziInfection

2000 • 76 citations

The Serpin Secreted byBrugia malayiMicrofilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans

2000 • 68 citations

Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes

1998 • 67 citations

Reproducible and inexpensive probe preparation for oligonucleotide arrays

2001 • 66 citations

A Random Sequencing Approach for the Analysis of the Trypanosoma cruzi Genome: General Structure, Large Gene and Repetitive DNA Families, and Gene Discovery

2000 • 62 citations

Protective Immune Responses Induced by Vaccination with an Expression Genomic Library ofLeishmania major

1999 • 59 citations

The Schistosoma gene discovery program: state of the art

2000 • 54 citations

The Surface Protein Superfamily ofTrypanosoma cruziStimulates a Polarized Th1 Response That Becomes Anergic

1999 • 53 citations

Parasite Proteomics

2000 • 53 citations

Preliminary results on the effect of tetracycline on the embryogenesis and symbiotic bacteria (Wolbachia) of Dirofilaria immitis. An update and discussion.

1998 • 53 citations

The genomes of Onchocerca volvulus

2000 • 51 citations

Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A–T rich genomes

2001 • 48 citations

Helminth genome analysis: the current status of the filarial and schistosome genome projects

1999 • 48 citations

Telomeric organization of a variable and inducible toxin gene family in the ancient eukaryote Giardia duodenalis.

1997 • 48 citations

A Random Survey of the Cryptosporidium parvum Genome

1999 • 48 citations

Gene Survey of the Pathogenic Protozoan Trypanosoma cruzi

2000 • 45 citations

A survey of the Leishmania major Friedlin strain V1 genome by shotgun sequencing: a resource for DNA microarrays and expression profiling

2001 • 44 citations

Analysis of the gene expression profile of Schistosoma mansoni cercariae using the expressed sequence tag approach

1999 • 43 citations

Rapid purification and characterization of l-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi

1998 • 42 citations

The size difference between Leishmania major Friedlin chromosome one homologues is localized to sub-telomeric repeats at one chromosomal end

2000 • 42 citations

Generation, Identification, and Evaluation of Expressed Sequence Tags from Different Developmental Stages of the Asian Blood FlukeSchistosoma japonicum

1998 • 40 citations

200 000 nematode expressed sequence tags on the Net

2001 • 40 citations

Cloning and Characterization of Leishmania donovani Telomeres

2000 • 36 citations

The Case for Deemphasizing Genomics in Malaria Control

2000 • 36 citations

FULL-malaria: a database for a full-length enriched cDNA library from human malaria parasite, Plasmodium falciparum

2001 • 33 citations

Expression library immunization protects mice against a challenge with virulent rodent malaria

2000 • 33 citations

Theileria parva genomics reveals an atypical apicomplexan genome

2000 • 31 citations

A Telomere-mediated Chromosome Fragmentation Approach to Assess Mitotic Stability and Ploidy Alterations of LeishmaniaChromosomes

2001 • 26 citations

The Plasmodium vivax and P. berghei Gene Sequence Tag Projects

2000 • 26 citations

Initiation of a Sarcocystis neurona expressed sequence tag (EST) sequencing project: a preliminary report

2001 • 26 citations

Gene discovery in Plasmodium chabaudi by genome survey sequencing

2001 • 25 citations

Organization and Structure of the Giardia Genome

1999 • 22 citations

Construction and Characterization of aPlasmodium vivaxGenomic Library in Yeast Artificial Chromosomes

1997 • 22 citations

Trypanosoma cruzi:Monoclonal Antibodies to the Surface Glycoprotein Superfamily Differentiate Subsets of the 85-kDa Surface Glycoproteins and Confirm Simultaneous Expression of Variant 85-kDa Surface Glycoproteins

1999 • 20 citations

Expression and evolution of members of the Trypanosoma cruzi trypomastigote surface antigen multigene family

1994 • 17 citations

Polymorphic open reading frames encoding secretory proteins are located less than 3 kilobases from Theileria parva telomeres

2000 • 14 citations

The polymorphic telomeres of the African trypanosome Trypanosoma brucei

2000 • 10 citations

Assessing the impact of Plasmodium falciparum genome sequencing

2000 • 9 citations

Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae

2000 • 8 citations