Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

1996 • 513 citations

Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.

1994 • 453 citations

A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells

1991 • 420 citations

Treatment of chronic Chagas' disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up

1994 • 328 citations

DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans.

1995 • 266 citations

Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major.

1995 • 171 citations

DNA vaccines

1996 • 148 citations

Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes.

1992 • 134 citations

Mammalian cell sialic acid enhances invasion by Trypanosoma cruzi

1993 • 93 citations

Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease.

1995 • 89 citations

Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities.

1992 • 82 citations

Invasive phenotype of Trypanosoma cruzi restricted to a population expressing trans-sialidase

1996 • 67 citations

A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxyl-terminal domain is active, monomeric, and generates antibodies that inhibit enzymatic activity.

1994 • 67 citations

Evidence for the participation of the Ssp-3 antigen in the invasion of nonphagocytic mammalian cells by Trypanosoma cruzi.

1992 • 55 citations

The role of T cells in Trypanosoma cruzi infections

1995 • 43 citations

Passive transfer of a monoclonal antibody specific for a sialic acid-dependent epitope on the surface of Trypanosoma cruzi trypomastigotes reduces infection in mice

1997 • 39 citations

Sera from chronic Chagasic patients and rodents infected with Trypanosoma cruzi inhibit trans-sialidase by recognizing its amino-terminal and catalytic domain

1994 • 35 citations

Genetic Immunization

1996 • 32 citations