Cell Proliferation and Cell Death in the Liver: Patterns, Mechanisms and Measurements

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

Growth Kinetics of Tumours

1978 • 691 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Review: assessment of cell proliferation in histological material.

1990 • 456 citations

Apoptosis: molecular mechanisms in programmed cell death.

1991 • 425 citations

The clinical assessment of proliferation and growth in human tumours: Evaluation of methods and applications as prognostic variables

1990 • 341 citations

The biology of epithelial cell populations

1984 • 339 citations

THE KINETICS OF CELLULAR PROLIFERATION IN REGENERATING LIVER

1968 • 288 citations

The streaming liver

1985 • 271 citations

Oxford textbook of pathology

2013 • 220 citations

Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage.

1993 • 181 citations

Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide.

1991 • 180 citations

Mechanisms of cell death

1991 • 174 citations

Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

1985 • 174 citations

Regulation of hepatic growth

1986 • 173 citations

Transforming growth factor-β 1 as a signal for induction of cell death by apoptosis

1993 • 173 citations

Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia

1986 • 144 citations

?Tissue? transglutaminase is specifically expressed in neonatal rat liver cells undergoing apoptosis upon epidermal growth factor-stimulation

1991 • 138 citations

Apoptosis: a gene-directed programme of cell death.

1992 • 115 citations

Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. A sequential study.

1984 • 115 citations

Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue.

1988 • 108 citations

Apoptosis—the mechanism of cell death in dimethylnitrosamine‐induced hepatotoxicity

1989 • 101 citations

Ca(++)-activated DNA fragmentation and dimethylnitrosamine-induced hepatic necrosis: effects of Ca(++)-endonuclease and poly(ADP-ribose) polymerase inhibitors in mice.

1992 • 58 citations

Assessment of Cell Proliferation in Clinical Practice

1992 • 50 citations

Proliferating Cell Nuclear Antigen Immunolocalization in Gastro-Intestinal Epithelia

1991 • 42 citations

Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver

1990 • 40 citations

Chemical Carcinogenesis 2

1991 • 8 citations

Stimulus Dependent Phenotypic Diversity in the Resistant Hepatocyte Model

1991 • 6 citations