Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

1993 • 1,022 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Hypoxia induces endothelin gene expression and secretion in cultured human endothelium.

1991 • 691 citations

Sickle Cell Disease: Basic Principles and Clinical Practice

1994 • 559 citations

Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease

1991 • 538 citations

Inhibition of nitric oxide synthesis by methylene blue

1993 • 519 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

1983 • 476 citations

Hypoxia on the pulmonary circulation. How and where it acts.

1976 • 465 citations

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

1985 • 461 citations

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

1993 • 445 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.

1990 • 390 citations

Optic nerve blood-flow abnormalities in glaucoma

1998 • 362 citations

Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia.

1991 • 321 citations

Anoxia and endothelium‐dependent reactivity of the canine femoral artery.

1983 • 259 citations

Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.

1984 • 257 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

Studies on Cobalt Myoglobins and Hemoglobins

1974 • 214 citations

Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells

1992 • 207 citations

Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.

1989 • 172 citations

Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs.

1994 • 170 citations

Characterization of endothelium-derived relaxing factor/nitric oxide synthase from bovine cerebellum and mechanism of modulation by high and low oxygen tensions.

1991 • 140 citations

Increasing oxygen tension dilates fetal pulmonary circulation via endothelium-derived relaxing factor

1993 • 132 citations

Hypoxic contraction of isolated rat pulmonary artery.

1989 • 121 citations

Endothelial Cells Synthesize Basic Fibroblast Growth Factor and Transforming Growth Factor Beta

1988 • 119 citations

Pulmonary vascular physiology and pathophysiology

1990 • 108 citations

Regulation of c-jun Expression during Hypoxic and Low-Glucose Stress

1994 • 104 citations

Acute and Prolonged Hypoxia Attenuate Endothelial Nitric Oxide Production in Rat Pulmonary Arteries by Different Mechanisms

1993 • 97 citations

A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts

1991 • 94 citations

Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types

1995 • 90 citations

H2O2 and cGMP may function as an O2 sensor in the pulmonary artery

1989 • 84 citations

Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes.

1994 • 83 citations

Regulation of c-jun expression during hypoxic and low-glucose stress.

1994 • 79 citations

Early effects of aldosterone on apical and basolateral membrane conductances of TBM cells

1992 • 77 citations

Pulmonary Endothelium-Derived Relaxing Factor is Impaired in Hypoxia

1989 • 72 citations

The Role of Endothelium in Hypoxic Constriction of Human Pulmonary Artery Rings

1993 • 70 citations

Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat

1992 • 67 citations

Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP

1991 • 67 citations

Loss of Endothelium-Dependent Relaxation in Proximal Pulmonary Arteries from Rats Exposed to Chronic Hypoxia: Effects of In Vivo and In Vitro Supplementation with l-Arginine

1993 • 52 citations

Inhibition of cGMP-associated pulmonary arterial relaxation to H2O2 and O2 by ethanol

1990 • 47 citations

Endotoxin enhances hypoxic constriction of rat aorta and pulmonary artery through induction of EDRF/NO synthase

1993 • 28 citations

Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells.

1994 • 10 citations

Ultrastructure of the lung in chronic hypoxia.

1994 • 10 citations

Prior episode of anoxia attenuates vasorelaxation in response to subsequent episode of anoxia

1994 • 6 citations