Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Biostatistical Analysis (2nd ed.).

1986 • 5,963 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

A NEW FLUOROMETRIC ASSAY FOR CYTOTOXICITY MEASUREMENTS IN-VITRO

1993 • 572 citations

Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae

1996 • 522 citations

Morphologic Changes in Pulmonary Oxygen Toxicity

1986 • 393 citations

Determination of lipid phosphorus in the nanomolar range

1970 • 389 citations

Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange.

1994 • 334 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements

1994 • 265 citations

Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.

1995 • 243 citations

High performance liquid chromatographic separation and direct ultraviolet detection of phospholipids

1977 • 234 citations

Increase in metallothionein produced by chemicals that induce oxidative stress

1991 • 232 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14α-sterol demethylase purified from Candida albicans

1990 • 179 citations

Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.

1994 • 166 citations

Direct Reaction of H2O2with Sulfhydryl Groups in HL-60 Cells: Zinc-Metallothionein and Other Sites

1996 • 139 citations

Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats

1995 • 123 citations

Metallothioneins and Cell Death by Anticancer Drugs

1995 • 119 citations

Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis

1997 • 98 citations

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

1990 • 96 citations

Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid

1996 • 74 citations

Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents

1989 • 66 citations

V79 Chinese-hamster cells rendered resistant to high cadmium concentration also become resistant to oxidative stress

1988 • 61 citations

Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cells

1995 • 61 citations

Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure.

1994 • 57 citations

Effect of oxygen and endotoxin on lactate dehydrogenase release, 5‐hydroxytryptamine uptake, and antioxidant enzyme activities in endothelial cells

1985 • 56 citations

Translocation of protein kinase C is associated with inhibition of 5-HT uptake by cultured endothelial cells

1989 • 53 citations

Cell-specific Alterations in Expression of Hyperoxia-induced mRNAs of Lung

1991 • 48 citations

Cross-tolerance to hyperoxia following cadmium aerosol pretreatment

1990 • 48 citations

Glutathione is the antioxidant responsible for resistance to oxidative stress in V79 Chinese hamster fibroblasts rendered resistant to cadmium

1992 • 45 citations

Acyl-trafficking in membrane phospholipid fatty acid turnover: The transfer of fatty acid from the acyl-L-carnitine pool to membrane phospholipids in intact human erythrocytes

1992 • 38 citations

Oxidant resistance of cadmium-adapted human lung fibroblasts

1995 • 24 citations

Cellular localization of metallothionein in the lung following repeated cadmium inhalation

1985 • 23 citations

Cadmium Ion-induced Alterations of Phospholipid Metabolism in Endothelial Cells

1991 • 13 citations

Induction of pulmonary metallothionein following oxygen exposure

1989 • 11 citations

Expression of Pulmonary Metallothionein Genes in Late Gestational Lambs

1992 • 10 citations

Increased oxidant resistance of alveolar macrophages isolated from rats repeatedly exposed to cadmium aerosols

1996 • 9 citations

Tolerance to Ozone Induced in Rats by Preexposure to Cadmium Chloride Aerosol

1989 • 6 citations