RRM1-induced metastasis suppression through PTEN-regulated pathways

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Cancer Statistics, 2002

2002 • 2,954 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Multicolor Spectral Karyotyping of Human Chromosomes

1996 • 1,780 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

2000 • 877 citations

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1999 • 787 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Rho GTPases: Signaling, Migration, and Invasion

2000 • 584 citations

Regulation of G₁progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1999 • 572 citations

From RNA to DNA, Why So Many Ribonucleotide Reductases?

1993 • 525 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.

1994 • 502 citations

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

1998 • 453 citations

Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

1999 • 418 citations

PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1999 • 367 citations

Ribonucleotide reductase: regulation, regulation, regulation

1992 • 305 citations

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

2000 • 291 citations

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

2001 • 228 citations

Promoter Methylation and Silencing of PTEN in Gastric Carcinoma

2002 • 227 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1998 • 198 citations

Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types

1998 • 195 citations

Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea

1993 • 135 citations

Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer.

1994 • 115 citations

Overexpression of transfected human ribonucleotide reductase M2 subunit in human cancer cells enhances their invasive potential.

1997 • 98 citations

The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

1997 • 97 citations

Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer

1991 • 95 citations

Ribonucleotide reductases in the twenty-first century

1998 • 91 citations

Profiling the Downstream Genes of Tumor Suppressor PTEN in Lung Cancer Cells by Complementary DNA Microarray

2000 • 75 citations

Mammalian ribonucleotide reductase R1 mRNA stability under normal and phorbol ester stimulating conditions: involvement of a cis-trans interaction at the 3′ untranslated region.

1993 • 67 citations

Total body irradiation (TBI) as primary therapy for advanced lymphosarcoma

1975 • 63 citations

Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1)

1999 • 54 citations

Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell‐mediated chromosome transfer

1993 • 53 citations

Transcript map and complete genomic sequence for the 310 kb region of minimal allele loss on chromosome segment 11p15.5 in non-small-cell lung cancer

2001 • 32 citations

Prognostic Significance of Molecular Genetic Aberrations on Chromosome Segment 11p15.5 in Non–Small-Cell Lung Cancer

2002 • 32 citations

Regulation of ribonucleotide reductase activity in mammalian cells

1983 • 29 citations

Defining a Novel cis-Element in the 3′-Untranslated Region of Mammalian Ribonucleotide Reductase Component R2 mRNA

1996 • 25 citations

An historical perspective of multi-modality treatment for resectable non-small cell lung cancer

1995 • 14 citations

DNA-Binding Activity of Wild-Type p53 Protein is Mediated by the Central Part of the Molecule and Controlled by Its C Terminus

1998 • 13 citations