Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase

1988 • 496 citations

Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats

1985 • 493 citations

The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions

1991 • 467 citations

A modified histochemical technique to visualize acetylcholinesterase-containing axons.

1985 • 441 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

1991 • 422 citations

Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor

1994 • 406 citations

Mood Disorder and Multiple Sclerosis

1987 • 390 citations

The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions

1985 • 386 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats

1987 • 352 citations

Animal models of Alzheimer's disease: experimental cholinergic denervation

1988 • 340 citations

Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes

1989 • 325 citations

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrain

1989 • 277 citations

Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of meynert in Alzheimer's disease

1982 • 239 citations

Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree)

1983 • 225 citations

The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

1988 • 210 citations

Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system

1992 • 204 citations

Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study

1989 • 198 citations

Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy

1987 • 193 citations

Near-total loss of ‘learning’ and ‘memory’ as a result of combined cholinergic and serotonergic blockade in the rat

1987 • 175 citations

Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?

1990 • 168 citations

A reappraisal of the functions of the nucleus basalis of Meynert

1988 • 151 citations

Potential Animal Models for Senile Dementia of Alzheimer's Type, with Emphasis on AF64A-Induced Cholinotoxicity

1986 • 148 citations

Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat

1992 • 146 citations

Scopolamine amnesia of passive avoidance: A deficit of information acquisition

1988 • 132 citations

An Immunotoxin Composed of Monoclonal Anti-Thy 1.1 Antibody and a Ribosome-Inactivating Protein From <italic>Saponaria officinalis:</italic> Potent Antitumor Effects In Vitro and In Vivo

1985 • 130 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

192 IgG-saporin : I. Specific Lethality for Cholinergic Neurons in the Basal Forebrain of the Rat

1994 • 106 citations

Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin

1994 • 104 citations

Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain

1988 • 102 citations

[20] Techniques in the tissue culture of rat sympathetic neurons

1983 • 86 citations

Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia

1986 • 81 citations

An ‘anatomical cascade hypothesis’ for Alzheimer's disease

1992 • 77 citations

Characterization of a Saponaria officinalis seed ribosome-inactivating protein: Immunoreactivity and sequence homologies

1985 • 77 citations

High-affinity choline uptake carrier in Alzheimer's disease: implications for the cholinergic hypothesis of dementia

1991 • 59 citations

Immunohistochemical detection of a monoclonal antibody directed against the NGF receptor in basal forebrain neurons following intraventricular injection

1991 • 58 citations

Immunohistochemical localization of β-nerve growth factor receptors in the forebrain of the rat

1988 • 57 citations

A Critical Review of the Role of the Cholinergic System in Human Memory and Cognition^a

1985 • 55 citations

Synthesis and characterization of an antihuman T-lymphocyte saporin immunotoxin (OKT1-SAP) with in vivo stability into nonhuman primates

1988 • 54 citations

Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

1992 • 54 citations

Nerve growth factor receptor-mediated transport from cerebrospinal fluid to basal forebrain neurons

1987 • 46 citations

Anti-Thy-1 immunotoxin, OX7-saporin, destroys cerebellar purkinje cells after intraventricular injection in rats

1989 • 45 citations

Behavioural and histological effects of low concentrations of intraventricular AF64A

1989 • 45 citations

Animal Models of Alzheimer's Disease: Behavior, Pharmacology, Transplants

1986 • 44 citations

Selective destruction of nerve growth factor receptor-bearing cells in vitro using a hybrid toxin composed of ricin A chain and a monoclonal antibody against the nerve growth factor receptor.

1985 • 43 citations

Neuronotoxic effects of monoclonal anti-Thy 1 antibody (OX7) coupled to the ribosome inactivating protein, saporin, as studied by suicide transport experiments in the rat

1989 • 38 citations

Nerve growth factor receptor-mediated transport from CSF labels cholinergic neurons: direct demonstration by a double-labeling study

1989 • 37 citations

Animal and drug modelling for Alzheimer synaptic pathology

1992 • 37 citations

The effects of ibotenic acid lesions of the nucleus basalis and cholinergic-rich neural transplants on win-stay/lose-shift and win-shift/lose-stay performance in the rat

1990 • 35 citations

Strategies for the Development of Animal Models of Human Memory Impairments^a

1985 • 33 citations

Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?

1992 • 31 citations

The need for common perspectives in the development and use of animal models for age-related cognitive and neurodegenerative disorders

1988 • 31 citations

Memory Disorders: Research and Clinical Practice

1991 • 28 citations

Animal test systems to study behavioral dysfunctions of neurodegenerative disorders.

1991 • 27 citations

Age-dependent effects of scopolamine on avoidance, locomotor activity, and rearing

1982 • 26 citations

Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody

1991 • 23 citations

Ultrastructural and neurochemical effects of the presumed cholinergic toxin AF64A in the rat interpeduncular nucleus

1986 • 22 citations

An attempt to cause the selective loss of the cholinergic neurons in the basal forebrain of the rat: A new animal model of Alzheimer's disease

1989 • 22 citations

Pathogenesis of Alzheimer's Disease — Beyond the Cholinergic Hypothesis: Discussion Paper

1986 • 20 citations

Persistent innervation of the rat neocortex by basal forebrain cholinergic neurons despite the massive reduction of cortical target neuronsII. Neurochemical analysis

1992 • 19 citations

Alzheimer's disease: a multisystem disorder.

1986 • 19 citations

Attempts to make models for Alzheimer's disease

1992 • 16 citations

Persistent innervation of the rat neocortex by basal forebrain cholinergic neurons despite the massive reduction of cortical target neuronsI. Morphometric analysis

1992 • 15 citations

Animal models of degenerative neurological disease.

1987 • 15 citations

6. The cholinergic system and the excitatory amino acids in Alzheimer's disease

2009 • 15 citations

Memory disorders. Research and clinical practice

1992 • 14 citations

The validity of animal models in the search for drugs for the aging brain.

1990 • 14 citations

Animal models of Alzheimer's disease: are they valid and useful?

1990 • 11 citations

Chapter 21 The old animal as a model in research on brain aging and Alzheimer's disease/senile dementia of the Alzheimer type

1986 • 9 citations

Searching for Models of Alzheimer's Disease: A Comparison of Four Amnestic Treatments in Two Behavioral Tasks

1985 • 7 citations

Animal models of brain ageing and dementia.

1987 • 7 citations

Criteria for development of animal models of diseases of the nervous system.

1980 • 5 citations

Intracerebral Injections of AF64A: An Animal Model of Alzheimer's Disease?

1985 • 5 citations

Needs for animal models of human diseases of the nervous system.

1980 • 5 citations

BASIC MODELS OF ALZHEIMERʼS DISEASE

1992 • 1 citations