Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Hsp90

2001 • 819 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

2002 • 526 citations

IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

2001 • 469 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90

2002 • 393 citations

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappaB

2002 • 369 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

2000 • 353 citations

NF- κ B and the innate immune response

2000 • 332 citations

Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation

2000 • 328 citations

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

2001 • 328 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

2002 • 213 citations

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

1999 • 202 citations

Activation of the IκB Kinases by RIP via IKKγ/NEMO-mediated Oligomerization

2000 • 171 citations

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

2003 • 156 citations

Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation

2003 • 135 citations

Lymphotoxin and lipopolysaccharide induce NF‐κB‐p52 generation by a co‐translational mechanism

2003 • 127 citations

The Molecular and Cellular Origins of Hodgkin's Disease

2000 • 102 citations

Hsp90 Is Essential for the Synthesis and Subsequent Membrane Association, But Not the Maintenance, of the Src-Kinase p56^lck

2000 • 87 citations

Hsp90 Regulates p50 Function during the Biogenesis of the Active Conformation of the Heme-regulated eIF2α Kinase

2001 • 83 citations

Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes

2000 • 65 citations

The Inhibitory Action of Sodium Arsenite on Lipopolysaccharide-Induced Nitric Oxide Production in RAW 267.4 Macrophage Cells: A Role of Raf-1 in Lipopolysaccharide Signaling

2001 • 57 citations

Effects of Geldanamycin, a Heat-Shock Protein 90-Binding Agent, on T Cell Function and T Cell Nonreceptor Protein Tyrosine Kinases

2000 • 52 citations

Immunosuppressive effects of the heat shock protein 90‐binding antibiotic geldanamycin

1999 • 22 citations

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

1999 • 20 citations

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