Functional genomics in mice by tagged sequence mutagenesis

Basic local alignment search tool

1990 • 87,358 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project

1991 • 2,286 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

Recent Advances in the Polymerase Chain Reaction

1991 • 1,068 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

1992 • 729 citations

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

1993 • 551 citations

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

1993 • 537 citations

Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression

1992 • 528 citations

Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes

1989 • 491 citations

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

1993 • 491 citations

Chromosome engineering in mice

1995 • 479 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Catalog Of Mutant Genes And Polymorphic Loci

1996 • 404 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation.

1995 • 329 citations

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.

1994 • 325 citations

Capturing genes encoding membrane and secreted proteins important for mouse development.

1995 • 321 citations

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

1994 • 315 citations

From DNA sequence to biological function

1996 • 309 citations

3,400 new expressed sequence tags identify diversity of transcripts in human brain

1993 • 292 citations

A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice.

1992 • 281 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

Units of transcription and translation: Sequence components of heterogeneous nuclear RNA and messenger RNA

1975 • 226 citations

Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development.

1992 • 219 citations

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

1993 • 158 citations

INTEGRATION SPECIFICITY OF RETROTRANSPOSONS AND RETROVIRUSES

1990 • 155 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

Distribution of targets for avian retrovirus DNA integration in vivo.

1994 • 123 citations

A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.

1995 • 121 citations

An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.

1996 • 119 citations

NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.

1993 • 115 citations

Targeting the mouse genome: a compendium of knockouts (part I)

1995 • 100 citations

Targeting the mouse genome: a compendium of knockouts (part II)

1995 • 99 citations

A fast and simple procedure for sequencing double stranded DNA with Sequenase

1991 • 98 citations

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

1994 • 95 citations

An insertional mutation in theBTF3 transcription factor gene leads to an early postimplantation lethality in mice

1995 • 95 citations

Selective disruption of genes expressed in totipotent embryonal stem cells.

1992 • 92 citations

Differential splicing-in of a proline-rich exon converts alphaNAC into a muscle-specific transcription factor.

1996 • 87 citations

Cell Cycle- and Terminal Differentiation-Associated Regulation of the Mouse mRNA Encoding a Conserved Mitotic Protein Kinase

1993 • 86 citations

Isolation of anonymous DNA sequences from within a submicroscopic X chromosomal deletion in a patient with choroideremia, deafness, and mental retardation.

1987 • 85 citations

Characterization of a gene trap insertion into a novel gene, cordon‐bleu, expressed in axial structures of the gastrulating mouse embryo

1995 • 68 citations

Molecular basis of mouse developmental mutants.

1991 • 68 citations

The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs

1992 • 65 citations

Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion.

1996 • 60 citations

Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase.

1993 • 51 citations

Fluorescence-activated sorting of totipotent embryonic stem cells expressing developmentally regulated lacZ fusion genes.

1992 • 48 citations

Transcriptional specificity of the pluripotent embryonic stem cell.

1996 • 38 citations

Enrichment of Insertional Mutants Following Retrovirus Gene Trap Selection

1993 • 35 citations

Pressing ahead with human genome sequencing

1995 • 27 citations

The sequence complexity of exons trapped from the mouse genome

1994 • 14 citations

[17] Retrovirus gene traps

1995 • 9 citations