Selective disruption of genes expressed in totipotent embryonal stem cells.

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Murine Developmental Control Genes

1990 • 594 citations

Effects of Intercistronic Length on the Efficiency of Reinitiation by Eucaryotic Ribosomes

1987 • 540 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Nucleotide sequences in Xenopus 5S DNA required for transcription termination

1981 • 515 citations

Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes

1989 • 491 citations

Transgenic Animals

1988 • 473 citations

5'-terminal cap structure in eucaryotic messenger ribonucleic acids

1980 • 463 citations

Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene

1983 • 422 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes

1991 • 262 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites

1987 • 248 citations

Chromosomal position or virus mutation permits retrovirus expression in embryonal carcinoma cells

1986 • 236 citations

Units of transcription and translation: Sequence components of heterogeneous nuclear RNA and messenger RNA

1975 • 226 citations

Evaluation of the “scanning model” for initiation of protein synthesis in eucaryotes

1980 • 223 citations

Transcriptionally active genome regions are preferred targets for retrovirus integration

1990 • 210 citations

Independent mechanisms involved in suppression of the moloney leukemia virus genome during differentiation of murine teratocarcinoma cells

1983 • 205 citations

Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression

1983 • 187 citations

Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.

1989 • 186 citations

Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome

1990 • 169 citations

Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death.

1987 • 133 citations

Insertion Mutagenesis of Embryonal Carcinoma Cells by Retroviruses

1985 • 132 citations

Efficient insertion of genes into the mouse germ line via retroviral vectors.

1985 • 126 citations

Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants.

1986 • 125 citations

Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells.

1987 • 118 citations

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.

1987 • 115 citations

Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner

1989 • 111 citations

Insertional mutagenesis in mice

1987 • 99 citations

Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells.

1989 • 99 citations

A stem cell-specific silencer in the primer-binding site of a retrovirus.

1991 • 90 citations

Evidence for a stem cell-specific repressor of Moloney murine leukemia virus expression in embryonal carcinoma cells.

1990 • 78 citations

Identification of cellular promoters by using a retrovirus promoter trap

1989 • 74 citations

Introduction of a viral thymidine kinase gene and the human β-globin gene into developmentally multipotential mouse teratocarcinoma cells

1980 • 72 citations

Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived "portable exons" carrying the Escherichia coli lacZ gene.

1989 • 71 citations

Molecular basis of mouse developmental mutants.

1991 • 68 citations

Two blocks in Moloney murine leukemia virus expression in undifferentiated F9 embryonal carcinoma cells as determined by transient expression assays

1989 • 67 citations

Expression of foreign genes from retroviral vectors in mouse teratocarcinoma chimaeras.

1985 • 62 citations

Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells

1991 • 57 citations

Integration-specific retrovirus expression in embryonal carcinoma cells.

1984 • 53 citations

Determinants of retrovirus gene expression in embryonal carcinoma cells

1991 • 47 citations

Isolation of cellular promoters by using a retrovirus promoter trap.

1990 • 47 citations

Retrovirus activation in embryonal carcinoma cells by cellular promoters.

1989 • 44 citations

Spontaneous germ line virus infection and retroviral insertional mutagenesis in eighteen transgenic Srev lines of mice.

1989 • 42 citations

Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.

1991 • 33 citations

A cellular enhancer of retrovirus gene expression in embryonal carcinoma cells.

1987 • 29 citations

Activation of an Enhancerless Gene by Chromosomal Integration

1986 • 22 citations

The Ability of EK Cells to Form Chimeras after Selection of Clones in G418 and Some Observations on the Integration of Retroviral Vector Proviral DNA into EK Cells

1985 • 21 citations

Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors.

1987 • 20 citations

Improved oligonucleotide labeling and hybridization assay for endogenous nonecotropic murine leukemia proviruses

1991 • 12 citations

Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

1989 • 9 citations