DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

2000 • 1,801 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

2000 • 1,426 citations

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1999 • 963 citations

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita

1994 • 857 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

1996 • 827 citations

Orphan Nuclear Receptors: From Gene to Function*

1999 • 789 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

Wilms' Tumor 1 and Dax-1 Modulate the Orphan Nuclear Receptor SF-1 in Sex-Specific Gene Expression

1998 • 593 citations

Immunolocalisation of oestrogen receptor beta in human tissues

2000 • 539 citations

Estrogen receptor interaction with co-activators and co-repressors☆

2000 • 473 citations

DAX-1 Inhibits SF-1-Mediated Transactivation via a Carboxy-Terminal Domain That Is Deleted in Adrenal Hypoplasia Congenita

1997 • 469 citations

Role of Ahch in gonadal development and gametogenesis

1998 • 451 citations

DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis

1997 • 436 citations

Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function

1996 • 404 citations

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

2000 • 367 citations

Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohistochemistry

1997 • 364 citations

Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1

1998 • 337 citations

Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.

1996 • 303 citations

The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression

2000 • 303 citations

Ontogeny of Estrogen Receptor-β Expression in Rat Testis**This work was supported by grants from the Swedish Medical Research Council (MFR K98–04P-12596–01A) and the Loo och Hans Ostermans Stiftelse (to G.G.J.M.K.) and a grant from the European Union (EU-PL95–1223; to B.v.d.B., P.T.v.d.S., and J.-Å.G.).

1999 • 227 citations

A Regulatory Role for RIP140 in Nuclear Receptor Activation

1998 • 222 citations

A Transcriptional Silencing Domain in DAX-1 Whose Mutation Causes Adrenal Hypoplasia Congenita

1997 • 186 citations

The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ

1999 • 179 citations

DAX-1 Blocks Steroid Production at Multiple Levels¹

1998 • 175 citations

The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors

2000 • 157 citations

Expression of estrogen receptor alpha and beta during mouse embryogenesis

1999 • 140 citations

Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)

1998 • 139 citations

Hormonal and developmental regulation of DAX-1 expression in Sertoli cells.

1996 • 128 citations

Orphan Receptor DAX-1 Is a Shuttling RNA Binding Protein Associated with Polyribosomes via mRNA

2000 • 122 citations

Dax-1 as One of the Target Genes of Ad4BP/SF-1

1999 • 119 citations

Interaction of the Corepressor Alien with DAX-1 Is Abrogated by Mutations of DAX-1 Involved in Adrenal Hypoplasia Congenita

2000 • 112 citations

Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2

1998 • 109 citations

Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors

1999 • 76 citations

Cloning and expression of a DAX1 homologue in the chicken embryo

2000 • 69 citations

Characterization of the mouse DAX-1 gene reveals evolutionary conservation of a unique amino-terminal motif and widespread expression in mouse tissue.

1996 • 60 citations

The Role of DAX-1 in Reproduction

1998 • 41 citations

Identification and Developmental Expression of the Estrogen Receptor α and β in the Baboon Fetal Adrenal Gland¹

1999 • 33 citations

Novel missense mutation (Leu466Arg) of theDAX1 gene in a patient with X-linked congenital adrenal hypoplasia

1999 • 19 citations