Neurotransmitters, anxiety and benzodiazepines: A behavioral review

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

Comparative Genomics of Listeria Species

2001 • 1,491 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.

1934 • 1,281 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?

1978 • 782 citations

GABAergic modulation of benzodiazepine binding site sensitivity

1978 • 726 citations

Serotonin and appetite

1984 • 579 citations

New concepts on the mechanism of action of benzodiazepines

1975 • 539 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

1976 • 494 citations

Opioid modulation of appetite

1983 • 452 citations

Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli

1977 • 373 citations

EXPERIMENTS ON ‘NEOPHOBIA’ IN WILD AND LABORATORY RATS

1958 • 364 citations

Possible involvement of GABA in the central actions of benzodiazepines.

1975 • 346 citations

Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects

1982 • 341 citations

Benzodiazepines: Anxiety-Reducing Activity by Reduction of Serotonin Turnover in the Brain

1972 • 339 citations

5-HT and anxiety

1984 • 325 citations

Sodium Valproate

1977 • 318 citations

Benzodiazepines in Clinical Practice

1974 • 317 citations

High affinity GABA receptors — Autoradiographic localization

1981 • 307 citations

A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety

1979 • 284 citations

Minor tranquillizers, stress and central catecholamine neurons

1971 • 279 citations

Direct evidence for an interaction of β-adrenergic blockers with the 5-HT receptor

1977 • 275 citations

The anxiogenic action of benzodiazepine antagonists

1982 • 263 citations

Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animals

1979 • 260 citations

Benzodiazepine receptors

1984 • 253 citations

A sensitive open field measure of anxiolytic drug activity

1981 • 242 citations

The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination

1962 • 240 citations

Sex differences in emotional behaviour in mammals including man: Endocrine bases

1971 • 240 citations

Tryptophan-5-hydroxylase: function and control.

1974 • 237 citations

Increase of ?antianxiety? activity and tolerance of behavioral depression during chronic administration of oxazepam

1968 • 232 citations

Evidence for a late evolutionary appearance of brain-specific benzodiazepine receptors: an investigation of 18 vertebrate and 5 invertebrate species

1978 • 231 citations

Multiple benzodiazepine receptor localization by light microscopic radiohistochemistry.

1981 • 224 citations

beta-Carbolines enhance shock-induced suppression of drinking in rats.

1983 • 217 citations

2-Arylpyrazolo[4,3-c]quinolin-3-ones: a novel agonist, a partial agonist and an antagonist of benzodiazepines

1982 • 215 citations

EFFECTS OF PUNISHMENT INTENSITY DURING VARIABLE‐INTERVAL REINFORCEMENT

1960 • 215 citations

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

1981 • 211 citations

Purinergic inhibition of diazepam binding to rat brain ()

1979 • 195 citations

Nicotinamide is a brain constituent with benzodiazepine-like actions

1979 • 191 citations

A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants

1979 • 191 citations

Tryptaminergic mechanisms in punished and nonpunished behavior.

1970 • 182 citations

Behavioral analogues of anxiety animal models

1983 • 180 citations

Benzodiazepines as appetite-enhancing compounds

1980 • 178 citations

Behavioral effects of benzodiazepines: A review

1977 • 170 citations

Differences in benzodiazepine receptor binding in maudsley reactive and maudsley non-reactive rats

1978 • 167 citations

Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites.

1979 • 166 citations

Anxiogenic and non-anxiogenic benzodiazepine antagonists

1983 • 165 citations

The effects of 5-HTP on para-chlorophenylalanine (p-CPA) attenuation of “conflict” behavior

1970 • 163 citations

FIXED‐RATIO PUNISHMENT¹

1963 • 163 citations

Benzodiazepine Dependence

1981 • 160 citations

Diazepam-induced eating and lever pressing for food in sated rats.

1974 • 158 citations

A simple and specific screen for benzodiazepine-like drugs

1971 • 145 citations

Effects of benzodiazepines on central serotonergic mechanisms.

1975 • 143 citations

Evidence of -noradrenergic reward receptors and serotonergic punishment receptors in the rat brain.

1973 • 141 citations

Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.

1975 • 141 citations

GABA stimulation and blockade in the hypothalamus and midbrain: Effects on feeding and locomotor activity

1977 • 140 citations

Use of antianxiety agents in anxious outpatients

1978 • 136 citations

The effects of benzodiazepines and serotonergic manipulations on punished responding

1979 • 136 citations

The effects of p-chlorophenylalanine on experimentally induced conflict in the rat

1969 • 135 citations

Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor

1978 • 133 citations

(−)-Propranolol inhibits the behavioural responses of rats to increased 5-hydroxytryptamine in the central nervous system

1976 • 125 citations

The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

1978 • 124 citations

DRUGS AND PUNISHED RESPONDING I: RATE‐DEPENDENT EFFECTS UNDER MULTIPLE SCHEDULES¹

1973 • 123 citations

Multiple benzodiazepine receptors: Evidence of a dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives)

1981 • 120 citations

Benzodiazepine receptors in “emotional” and “non-emotional” mice: Comparison of four strains

1979 • 120 citations

Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat

1976 • 119 citations

Minor tranquilizers and brain defense systems.

1981 • 119 citations

Effets des anxiolytiques sur la prise de nourriture de rats et de souris plac�s en situation nouvelle ou famili�re

1975 • 118 citations

Benzodiazepines in clinical practice

1975 • 108 citations

Molecular substrates of anxiety: Clues from the heterogeneity of benzodiazepine receptors

1982 • 105 citations

Naloxone reduces social and exploratory activity in the rat

1980 • 103 citations

A water lick conflict paradigm using drug experienced rats

1981 • 103 citations

Benzodiazepine Receptors

1981 • 101 citations

Naloxone inhibits diazepam-induced feeding in rats

1979 • 99 citations

GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol

1979 • 97 citations

Do the reductions in social interaction produced by picrotoxin and pentylenetetrazole indicate anxiogenic actions?

1984 • 91 citations

Differential effects of naloxone against the diazepam-induced release of behavior in rats in three aversive situations

1980 • 90 citations

Altered 5-HT metabolism with clonazepam, diazepam and diphenylhydantoin

1975 • 89 citations

Muscimol induced feeding: A model to study the hypothalamic regulation of appetite

1981 • 88 citations

Sex and strain differences in septal driving of the hippocampal theta rhythm as a function of frequency: Effects of gonadectomy and gonadal hormones

1977 • 87 citations

The neuropharmacology of various diazepam antagonists

1983 • 86 citations

First Clinical Investigation of the Benzodiazepine Antagonist Ro 15-1788 in Comatose Patients

1983 • 84 citations

ANXIETY

1982 • 84 citations

Determinants of drug effects on punished responding

1975 • 84 citations

RELATIVE POTENCIES OF BENZODIAZEPINES AS MEASURED BY THEIR EFFECTS ON CONFLICT BEHAVIOR.

1964 • 81 citations

Benzodiazepines: behavioral and neurochemical mechanisms

1977 • 80 citations

Evidence that GABA in the nucleus dorsalis raphé induces stimulation of locomotor activity and eating behavior

1979 • 79 citations

The central GABAergic system and control of food intake under different experimental conditions

1980 • 79 citations

Evidence that gaba mechanisms mediate the anxiolytic action of benzodiazepines: A study with valproic acid

1980 • 78 citations

Benzodiazepines modulate striatal enkephalin levels via a gabaergic mechanism

1980 • 78 citations

Rapid changes in enkephalin levels in rat striatum and hypothalamus induced by diazepam

1979 • 78 citations

Effects of reserpine and morphine on behavior suppressed by punishment

1963 • 77 citations

Naloxone antagonism of diazepam-induced feeding in the Syrian hamster

1981 • 76 citations

Effect of valproic acid on [3H]diazepam and [3H]dihydropicrotoxinin binding sites at the benzodiazepine-GABA receptor-ionophore complex

1981 • 74 citations

Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines

1981 • 73 citations

Lack of central 5-hydroxytryptamine influence on the anticonflict activity of diazepam

1982 • 73 citations

Hyponeophagia and arousal in rats: Effects of diazepam, 5-methoxy-N,N-dimethyltryptamine, d-amphetamine and food deprivation

1982 • 73 citations

Is Ro15-1788 a partial agonist at benzodiazepine receptors?

1983 • 72 citations

Partial anxiolytic action of morphine sulphate following microinjection into the central nucleus of the amygdala in rats

1979 • 72 citations

Sodium valproate enhancement of gamma-aminobutyric acid (GABA) inhibition: electrophysiological evidence for anticonvulsant activity.

1981 • 71 citations

The discriminative stimulus properties of LSD: Mechanisms of action☆

1978 • 70 citations

Evidence against the involvement of serotonergic neurons in the anti-punishment activity of diazepam in the rat

1984 • 69 citations

Inosine May Be an Endogenous Ligand for Benzodiazepine Receptors on Cultured Spinal Neurons

1979 • 69 citations

Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior

1983 • 67 citations

Naloxone blocks the effect of diazepam and meprobamate on conflict behaviour in rats

1981 • 64 citations

Displacement of [3H] diazepam binding in rat brain by dipyridamole and by 1-methylisoguanosine, a marine natural product with muscle relaxant activity

1980 • 63 citations

The effect of psychotropic drugs on food reinforced behaviour and on food consumption

1968 • 63 citations

Drugs and the Inheritance of Behavior

1978 • 59 citations

Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines

1982 • 58 citations

RESPONDING MAINTAINED BY THE OPPORTUNITY TO ATTACK DURING AN INTERVAL FOOD REINFORCEMENT SCHEDULE¹

1973 • 57 citations

Sex and strain differences in benzodiazepine receptor binding in Roman rat strains

1982 • 57 citations

Sodium di-n-propylacetate (valproate) potentiates responses to GABA and muscimol on single central neurones

1980 • 56 citations

Anorexic effects of ethanolamine-O-sulfate and muscimol in the rat: Evidence that GABA inhibits ingestive behavior

1980 • 54 citations

GABA and hypothalamic feeding systems. II. A comparison of GABA, glycine and acetylcholine agonists and their antagonists

1979 • 54 citations

Effects of diazepam and of serotonin agonists on hyponeophagia in rats

1982 • 54 citations

Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component

1980 • 53 citations

Clonazepam induces decreased serotoninergic activity in the mouse brain

1979 • 51 citations

Management of the Office Patient With Anxiety and Depression

1965 • 50 citations

Effects of combined treatment with trifluoperazine-HCl and amobarbital on punished behavior in rats

1969 • 49 citations

Adenosine receptor interactions and anxiolytics

1983 • 48 citations

Benzodiazepine-induced voraciousness in cats and inhibition of amphetamine-anorexia

1976 • 46 citations

Effects of naloxone on anti-conflict and hyperphagic actions of diazepam

1981 • 44 citations

The readiness to eat and drink: The effect of deprivation conditions.

1962 • 44 citations

The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents

1984 • 43 citations

Effect of diazepam on food consumption in rats

1978 • 43 citations

Enhanced choice of familiar food in a food preference test after chlordiazepoxide administration

1978 • 43 citations

β‐ADRENOCEPTOR BLOCKING AGENTS AND RESPONSES TO ADRENALINE AND 5‐HYDROXYTRYPTAMINE IN RAT ISOLATED STOMACH AND UTERUS

1974 • 42 citations

Effects of chlordiazepoxide and diazepam on feeding performance in a food-preference test

1980 • 42 citations

Effects compar�s du muscimol et du diaz�pam sur les inhibitions du comportement induites chez le rat par la nouveaut�, la punition et le non-renforcement

1979 • 41 citations

The effect of solvents on the potency of chlordiazepoxide, diazepam, medazepam and nitrazepam

1971 • 40 citations

Evidence for the involvement of brain GABA and serotonin systems in the anticonflict effects of chlordiazepoxide in rats

1984 • 40 citations

Diazepam-induced release of opioid activity in the rat brain

1980 • 39 citations

Benzodiazepine Receptors

1984 • 39 citations

Head twitches induced by benzodiazepines and the role of biogenic amines

1976 • 38 citations

Sodium valproate exerts anti-conflict activity in rats without any concomitant rise in forebrain GABA level

1981 • 37 citations

Reinforcement schedules and extrapolations to humans from animals in behavioral pharmacology

1975 • 37 citations

Action of the benzodiazepines on the cholinergic system.

1975 • 37 citations

Benzodiazepines and neurotransmitters.

1980 • 36 citations

Effects of chlordiazepoxide, food familiarization, and prior shock experience on food choice in rats

1980 • 35 citations

Anxiolytic actions of chlordiazepoxide determine its effects on hyponeophagia in rats

1984 • 35 citations

Effect of benzodiazepines on central serotonergic neuron systems

1977 • 34 citations

β-Adrenoceptor antagonists may attenuate hyponeophagia in the rat through a serotonergic mechanism

1982 • 33 citations

Effects of diazepam and picrotoxin on hyponeophagia in rats☆

1982 • 32 citations

Effects of γ-vinyl GABA on food intake of rats

1982 • 32 citations

Feeding parameters with two food textures after chlordiazepoxide administration, alone or in combination with d-amphetamine or fenfluramine

1979 • 31 citations

Electrophysiological actions of benzodiazepines.

1980 • 31 citations

Chlordiazepoxide-induced hyperphagia in rats: lack of effect of GABA agonists and antagonists

1984 • 30 citations

3H-Diazepam binding sites in roman high- and low-avoidance rats

1981 • 30 citations

The role of central glycine receptors in the pharmacologic actions of benzodiazepines.

1975 • 29 citations

The effects of parachlorophenylalanine on experimentally induced conflict behavior

1973 • 29 citations

Antagonism by propranolol of isolation-induced aggression in mice: Correlation with 5-hydroxytryptamine receptor blockade

1980 • 28 citations

FUNCTIONAL CHANGES IN CEREBRAL 5‐HYDROXYTRYPTAMINE METABOLISM IN THE MOUSE INDUCED BY ANTICONVULSANT DRUGS

1978 • 28 citations

Effect of sodium valporate on hypothalamic neurons in vivo and in vitro

1981 • 28 citations

Chlordiazepoxide and preference for free food in rats

1975 • 28 citations

Enhanced suppressive effects of aversive events induced in rats by picrotoxin: Possibility of a GABA control on behavioral inhibition

1979 • 28 citations

Bicuculline blocks diazepam-induced feeding in Syrian hamsters

1982 • 27 citations

Gaba and endorphln mechanisms in relation to the effects of benzodiazepines on feeding and drinking

1983 • 25 citations

Effects of enantiomers of oxazepam sodium hemisuccinate on water intake and antagonism of picrotoxin- or naloxone-induced suppression of drinking by chlordiazepoxide in the rat

1980 • 25 citations

Antagonism of the central effects of 3‐methylclonazepam.

1982 • 25 citations

THIP inhibits feeding behavior in fasted rats

1982 • 24 citations

Effects of chlordiazepoxide and of valproate on hyponeophagia in rats Evidence for a mutual antagonism between their anxiolytic properties

1984 • 24 citations

CHLORDIAZEPOXIDE AND FOOD INTAKE IN THE RAT

1965 • 23 citations

Effects of valproate on hyponeophagia in rats: Competitive antagonism with picrotoxin and non-competitive antagonism with RO 15-1788

1985 • 22 citations

Pyrazapon (CI-683): A new antianxiety agent

1974 • 22 citations

A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788

1983 • 22 citations

Reduction of conditioned suppression: actions of morphine compared with those of amphetamine, pentobarbital, nalorphine, cocaine, LSD-25 and chlorpromazine.

1967 • 20 citations

Hyponeophagia in the Roman rat strains: Effects of 5-methoxy-N,N-dimethyltryptamine, diazepam, methysergide and the stereoisomers of propranolol

1983 • 19 citations

Animal models of anxiety and benzodiazepine actions.

1980 • 19 citations

Effects of chronic chlordiazepoxide treatment on novel and familiar food preference in rats

1981 • 18 citations

Evidence of a role for GABA in benzodiazepine effects on food preference in rats

1981 • 18 citations

Propranolol antagonism of morphine-influenced behavior

1974 • 17 citations

Relationships between hyponeophagia, diazepam sensitivity and benzodiazepine receptor binding in eighteen rat genotypes

1984 • 17 citations

The effect of diazepam and picrotoxin on brainstem evoked dorsal root potentials

1976 • 16 citations

Comparison of chlordiazepoxide and food deprivation in rats on a fixed-ratio satiation schedule

1973 • 16 citations

GABA-benzodiazepine interactions: electrophysiological, developmental and pharmacological aspects

1979 • 15 citations

Mechanism of action of benzodiazepines—the GABA hypothesis

1978 • 14 citations

Effect of valproic acid on anxiety related behaviors in the rat

1979 • 12 citations

Effects of naloxone on aversive trigeminal and thalamic stimulation, and on peripheral nociception: a hypothesis of selective action and variability in naloxone testing

1979 • 11 citations

Drugs and the inheritance of behavior

1979 • 11 citations

An endogenous ligand to the benzodiazepine receptor: Preliminary evaluation of its bioactivity

1981 • 11 citations

The effect of morphine on fear extinction in rats

1978 • 10 citations

A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice

1981 • 10 citations

Behavioral neurochemistry of benzodiazepines.

1980 • 9 citations

Drugs and punished responding VI: body weight as a determinant of drug effects.

1976 • 9 citations

Antipunishment effects of diazepam: Interaction with shock and food deprivation levels in pigs

1978 • 8 citations

Age, type and duration of deprivation, and consummatory preference in the rat.

1963 • 4 citations

Deleted Work

1955 • 0 citations