The neuropharmacology of various diazepam antagonists

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

1977 • 1,246 citations

Selective antagonists of benzodiazepines

1981 • 1,235 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

Agonist and antagonist benzodiazepine receptor interaction in vitro

1981 • 383 citations

Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats

1981 • 225 citations

Benzodiazepine Antagonist Ro 15–1788: Binding Characteristics and Interaction with Drug‐Induced Changes in Dopamine Turnover and Cerebellar cGMP Levels

1982 • 222 citations

2-Arylpyrazolo[4,3-c]quinolin-3-ones: a novel agonist, a partial agonist and an antagonist of benzodiazepines

1982 • 215 citations

β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity

1980 • 193 citations

CGS 8216: Receptor binding characteristics of a potent benzodiazepine antagonist

1982 • 192 citations

Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system

1978 • 189 citations

The proconvulsant and diazepam-reversing effects of ethyl-β-carboline-3-carboxylate

1980 • 162 citations

Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788

1981 • 156 citations

INVESTIGATION IN MAN OF THE EFFICACY OF A BENZODIAZEPINE ANTAGONIST, Ro 15-1788

1981 • 128 citations

Benzodiazepine antagonism by harmane and other β-carbolines in vitro and in vivo

1981 • 124 citations

The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

1978 • 124 citations

Caffeine antagonizes several central effects of diazepam

1981 • 123 citations

1-Methyl-?-carboline (Harmane), a potent endogenous inhibitor of benzodiazepine receptor binding

1980 • 119 citations

A water lick conflict paradigm using drug experienced rats

1981 • 103 citations

Mechanisms of Action of Benzodiazepines

1979 • 91 citations

Differential effects of naloxone against the diazepam-induced release of behavior in rats in three aversive situations

1980 • 90 citations

Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain

1982 • 88 citations

Ethyl β-carboline-3-car☐ylate antagonizes the action of GABA and benzodiazepines in the hippocampus

1981 • 88 citations

Benzodiazepines: behavioral and neurochemical mechanisms

1977 • 80 citations

Concentration Oscillations and Efficiency: Glycolysis

1981 • 78 citations

Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions

1982 • 77 citations

Naloxone antagonism of diazepam-induced feeding in the Syrian hamster

1981 • 76 citations

EFFECTS OF DIAZEPAM ON ADENOSINE AND ACETYLCHOLINE RELEASE FROM RAT CEREBRAL CORTEX: FURTHER EVIDENCE FOR A PURINERGIC MECHANISM IN ACTION OF DIAZEPAM

1980 • 76 citations

Naloxone blocks the effect of diazepam and meprobamate on conflict behaviour in rats

1981 • 64 citations

The use of naloxone in the treatment of diazepam poisoning

1975 • 63 citations

Behavioral characterization of two long-lasting adenosine analogs: Sedative properties and interaction with diazepam

1981 • 61 citations

Interaction Between Purine and Benzodiazepine: Inosine Reverses Diazepam-Induced Stimulation of Mouse Exploratory Behavior

1981 • 61 citations

Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors

1981 • 58 citations

An in vitro binding assay which differentiates benzodiazepine ‘agonists’ and ‘antagonists’

1982 • 55 citations

Purinergic Regulation of Food Intake

1982 • 50 citations

Proconvulsant effects in baboons of β-carboline, a putative endogenous ligand for benzodiazepine receptors

1981 • 50 citations

Effects of combined treatment with trifluoperazine-HCl and amobarbital on punished behavior in rats

1969 • 49 citations

Central Nervous System Depressants

2000 • 49 citations

Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine.

1979 • 48 citations

Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons

1979 • 47 citations

Aminophylline is a Diazepam Antagonist

1982 • 46 citations

3-Hydroxymethyl-β-carboline antagonizes some pharmacologic actions of diazepam

1981 • 46 citations

Effects of naloxone on anti-conflict and hyperphagic actions of diazepam

1981 • 44 citations

The use of physostigmine as an antidote in accidental diazepam intoxication

1975 • 42 citations

Reversal of Diazepam-induced Postanesthetic Somnolence with Physostigmine

1979 • 39 citations

Specific benzodiazepine antagonist R015-1788 and thirst-induced drinking in the rat

1982 • 37 citations

Physostigmine Reversal of Diazepam-lnduced Hypnosis

1979 • 37 citations

Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures

1981 • 36 citations

Aminophylline Is a Diazepam Antagonist

1981 • 35 citations

Properties of [3H] ß-carboline-3-carboxylate ethyl ester binding to the benzodiazepine receptor

1981 • 31 citations

Benzodiazepine receptor increase following repeated pentylenetetrazole injections

1981 • 31 citations

Pharmacologic and behavioral effects of EMD 28422: A novel purine which enhances (3H) diazepam binding to brain benzodiazepine receptors

1980 • 30 citations

Physostigmine, a highly potent antidote for acute experimental diazepam intoxication

1978 • 27 citations

Bicuculline blocks diazepam-induced feeding in Syrian hamsters

1982 • 27 citations

Benzodiazepine antagonists abolish electrophysiological effects of sodium valproate in the rat

1982 • 26 citations

Physostigmine-Atropine Solution Fails to Reverse Diazepam Sedation

1981 • 23 citations

[3H]ethyl β-carboline-3-carboxylate binding to the benzodiazepine receptors is not affected by GABA

1981 • 22 citations

Food-choice in a food-preference test: comparison of two mouse strains and the effects of chlordiazepoxide treatment

1979 • 16 citations

Binding of β-Carboline-3-Carboxylic acid ethyl ester to mouse brain benzodiazepine receptors in vivo

1981 • 14 citations

Antagonism of benzodiazepine binding in rat and human brain by antiliriumR

1979 • 12 citations

Ethyl β-carboline-3-carboxylate reverses the diazepam effect on cerebellar cyclic GMP

1982 • 11 citations

Convulsant benzodiazepine Ro 5-3663 has anxiolytic properties

1982 • 10 citations

Oxolinic acid and diazepam: Their reciprocal antagonism in rodents

1980 • 10 citations

Physostigmine-Atropine Solution Fails to Reverse Diazepam Sedation

1980 • 9 citations

New Valiums and Anti-Valiums on the Horizon

1982 • 9 citations

Physostigmine reversal of diazepam-induced hypnosis

1980 • 5 citations