Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers

Genomic sequencing.

1984 • 8,343 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies

1954 • 2,755 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

1991 • 385 citations

Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture.

1984 • 363 citations

Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

1995 • 313 citations

Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

1994 • 277 citations

Hepatitis C-associated hepatocellular carcinoma

1990 • 248 citations

Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC

1987 • 230 citations

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.

1994 • 168 citations

Telomere capture stabilizes chromosome breakage

1993 • 154 citations

p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis.

1994 • 139 citations

Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma

1992 • 139 citations

Telomere shortening in renal cell carcinoma.

1994 • 101 citations

Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C virus-positive cirrhotic patients

1994 • 98 citations

Control of G1 arrest after DNA damage.

1993 • 64 citations