Virus-immune T cells and the major histocompatibility complex: Evolution of some basic concepts over the past two years

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

The somatic generation of immune recognition

1971 • 974 citations

Cytotoxic T-Cell Immunity to Influenza

1983 • 932 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis

1974 • 832 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface

1985 • 579 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS

1975 • 488 citations

Hybrid antibodies can target sites for attack by T cells

1985 • 479 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Sequence and expression of transcripts of the human T-cell receptor β- chain genes

1984 • 380 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

1983 • 300 citations

Gene for α-Chain of Human T-Cell Receptor: Location on Chromosome 14 Region Involved in T-Cell Neoplasms

1985 • 300 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.

1977 • 285 citations

HLA restriction of cell-mediated lysis of influenza virus-infected human cells

1977 • 274 citations

Quantitative variation in la antigen expression plays a central role in immune regulation

1984 • 270 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

Ontogeny of the T-cell antigen receptor within the thymus

1985 • 250 citations

Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

1983 • 237 citations

Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells

1984 • 234 citations

Reorganisation of spinal cord sensory map after peripheral nerve injury

1978 • 232 citations

Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses

1977 • 229 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Expression of influenza A virus internal antigens on the surface of infected P815 cells.

1981 • 206 citations

The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

1984 • 204 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.

1982 • 199 citations

Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes

1985 • 193 citations

Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function

1984 • 185 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.

1984 • 178 citations

Genetics of Influenza Viruses

1983 • 175 citations

Antigen‐specific cytotoxic T cell and antigen‐specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3

1985 • 175 citations

Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus

1981 • 174 citations

Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

1978 • 166 citations

Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

1978 • 166 citations

The Human T Cell Receptor: Analysis with Cytotoxic T Cell Clones

1983 • 163 citations

Lymphokine‐Driven “Differentiation” of Cytotoxic T‐Cell Clones into Cells with NK‐Like Specificity: Correlations with Display of Membrane Macromolecules

1983 • 158 citations

Immunologic recognition of influenza virus-infected cells

1977 • 158 citations

Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture

1984 • 147 citations

Expression of genes of the T-cell antigen receptor complex in precursor thymocytes

1985 • 135 citations

Antigen processing and presentation to T cells

1985 • 120 citations

A viral polymerase involved in recognition of influenza virus-infected cells by a cytotoxic T-cell clone

1982 • 113 citations

Models for recognition of virally modified cells by immune thymus-derived lymphocytes

1976 • 111 citations

Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses.

1977 • 98 citations

Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene

1985 • 95 citations

Influenza virus-specific human cytotoxic T cell clones: Heterogeneity in antigenic specificity and restriction by class II MHC products

1984 • 92 citations

The gene encoding the T-cell receptor α-chain maps close to the Np-2 locus on mouse chromosome 14

1985 • 89 citations

Investigation of early T cell activation: Analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration

1985 • 88 citations

Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci.

1983 • 87 citations

Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer.

1984 • 84 citations

Vaccinia-specific cytotoxic T-cell responses in the context of H-2 antigens not encountered in thymus may reflect aberrant recognition of a virus-H-2 complex.

1979 • 80 citations

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

1985 • 79 citations

Monoclonal Antibodies and Functional Cell Lines

1984 • 76 citations

Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins.

1983 • 76 citations

Options for the control of influenza

1986 • 75 citations

Mhc RESTRICTION AND Ir GENES

1982 • 73 citations

Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor β-chain gene

1985 • 72 citations

HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus.

1979 • 70 citations

Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones.

1984 • 69 citations

Limiting dilution analysis of the specificity of influenza-immune cytotoxic T cells

1982 • 68 citations

The regulation of the immune system

1984 • 64 citations

The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (AG-B) in rats and identification of a new alloantigen system showing no AG-B restriction.

1977 • 62 citations

T-cell receptors generated via mutations are specific for various major histocompatibility antigens

1984 • 61 citations

Augmentation of immunity to herpes simplex virus by in vivo administration of interleukin 2.

1985 • 58 citations

B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg.

1985 • 58 citations

Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.

1982 • 58 citations

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells

1984 • 56 citations

The human T-cell receptor α-chain gene maps to chromosome 14

1985 • 54 citations

Specificity studies on cytotoxic thymus-derived lymphocytes reactive with influenza virus-infected cells: evidence for dual recognition of H-2 and viral hemagglutinin antigens.

1977 • 53 citations

Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA

1983 • 52 citations

Host immune response to reovirus: CTL recognize the major neutralization domain of the viral hemagglutinin.

1982 • 48 citations

Different rules govern help for cytotoxic T cells and B cells

1978 • 48 citations

Lyt phenotypes of primary cytotoxic T cells generated across the A and E region of the H‐2 complex

1981 • 46 citations

Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone

1984 • 45 citations

Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis

1985 • 44 citations

Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones.

1985 • 42 citations

Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis

1985 • 41 citations

THE IMMUNOLOGY OF INFLUENZA

1985 • 37 citations

T CELLS AND VIRAL INFECTIONS

1985 • 36 citations

Limit-dilution analysis of weak influenza-immune T cell responses associated with H-2Kb and H-2Db.

1982 • 34 citations

Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus.

1983 • 34 citations

Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. II. Competitive inhibition of I-E-restricted, antigen-specific T cell responses.

1984 • 34 citations

Cloned cytotoxic T lymphocytes recognize cells expressing discrete fragments of the SV40 tumor antigen.

1984 • 33 citations

Simian virus 40 specific cytotoxic lymphocyte clones localize two distinct TSTA sites on cells synthesizing a 48 kD SV40 T antigen

1984 • 30 citations

Development and Loss of Virus‐Specific Thymic Competence in Bone Marrow Radiation Chimeras and Normal Mice

1981 • 27 citations

Cell-extracellular matrix interactions in morphogenesis: an in vitro approach

1986 • 25 citations

Cross-reactivity patterns of vaccinia-specific cytotoxic T lymphocytes from H-2K b mutants

1983 • 22 citations

An Examination of MHC Restriction in the Context of a Minimal Clonal Abortion Model for Tolerance

1980 • 19 citations

Cell-mediated immunity and the CNS a key role for γ interferon

1985 • 14 citations

Negative selection experiments support the idea that T-T help is required for the H-Y-specific cytotoxic T cell response

1981 • 11 citations

Beneficial effect of cyclosporin A on the lymphocytic choriomeningitis virus infection in mice

1984 • 11 citations

Endogenous synthesis of Ia antigens by a cloned T cell line.

1984 • 11 citations

Genetics of influenza viruses

1985 • 9 citations

The T-Cell Receptor—the Genes and Beyond

1985 • 8 citations

Rat natural killer cell and cytotoxic T cell lysis of H‐2‐negative murine embryonal carcinoma cells

1985 • 8 citations

Molecular Bases of Neuronal Individuality

1984 • 6 citations

Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigens

1983 • 4 citations

Obscured Reactions in the Agglutination Test for Bacillary White Diarrhea

1926 • 3 citations

Not distinguish between serologically distinct type a viruses.

1977 • 1 citations