cAMP-dependent protein kinase and the disruption of learning in transgenic flies

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Classical conditioning and retention in normal and mutantDrosophila melanogaster

1985 • 1,170 citations

A cyclic nucleotide-gated conductance in olfactory receptor cilia

1987 • 1,134 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

1969 • 775 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Analysis of P transposable element functions in drosophila

1984 • 733 citations

DrosophilaMushroom Body Mutants are Deficient in Olfactory Learning

1985 • 695 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

dunce, a mutant of Drosophila deficient in learning.

1976 • 620 citations

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant

1984 • 589 citations

Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing

1986 • 568 citations

Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia

1973 • 493 citations

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

1981 • 444 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

Presynaptic Facilitation as a Mechanism for Behavioral Sensitization in Aplysia

1976 • 369 citations

Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.

1980 • 363 citations

Isolation of phosphorylated peptides and proteins on ion exchange papers

1978 • 359 citations

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

1988 • 286 citations

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase.

1986 • 253 citations

TWO CLOSELY LINKED MUTATIONS IN DROSOPHILA MELANOGASTER THAT ARE LETHAL TO OPPOSITE SEXES AND INTERACT WITH DAUGHTERLESS

1978 • 248 citations

Analysis of the Promoter of the ninaE Opsin Gene in Drosophila melanogaster

1987 • 230 citations

The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.

1987 • 223 citations

Facilitatory transmitter causes a selective and prolonged increase in adenosine 3':5'-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia

1982 • 215 citations

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

1982 • 207 citations

Neurogenetic Dissection of Learning and Short-Term Memory in Drosophila

1988 • 202 citations

Two genes encode related cytoplasmic elongation factors 1α (EF-1α) inDrosophila melanogasterwith continuous and stage specific expression

1988 • 191 citations

Isolation and characterization of Drosophila cAMP-dependent protein kinase genes.

1988 • 184 citations

Modulation of ION Channels in Neurons and Other Cells

1988 • 176 citations

Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase.

1985 • 174 citations

Complex modes of heat shock factor activation.

1990 • 141 citations

Recombinant Fragment of Protein Kinase Inhibitor Blocks Cyclic AMP-Dependent Gene Transcription

1987 • 139 citations

Colour vision inDrosophila melanogaster

1977 • 113 citations

Learning and Memory in Drosophila, Studied with Mutants

1983 • 113 citations

Characterization of a cyclic AMP-binding protein from bakers' yeast. Identification as a regulatory subunit of cyclic AMP-dependent protein kinase.

1980 • 111 citations

Are the structural changes in adult Drosophila mushroom bodies memory traces? Studies on biochemical learning mutants.

1987 • 109 citations

Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle.

1985 • 105 citations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.

1989 • 99 citations

Properties of learning and memory inDrosophila melanogaster

1977 • 85 citations

Pseudosubstrates turn off protein kinases

1988 • 81 citations

Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant.

1990 • 76 citations

Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period

1989 • 69 citations

Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis

1987 • 69 citations

Drosophila cAMP-dependent protein kinase.

1984 • 68 citations

The structural domains of cAMP-dependent protein kinase I. Characterization of two sites of proteolytic cleavage and homologies to cAMP-dependent protein kinase II.

1980 • 65 citations

Drosophila learning and memory revisited

1987 • 64 citations

Cloning, sequence, and expression of the Drosophila cAMP-dependent protein kinase catalytic subunit gene.

1988 • 63 citations

Expression of Wild-type and Mutant Subunits of the cAMP-dependent Protein Kinase

1988 • 46 citations

Ca²⁺-Dependent Proteolytic Modification of the Camp-Dependent Protein Kinase in Drosophila Wild-Type and Dunce Memory Mutants

1989 • 45 citations

Are the structural changes in adult Drosophila mushroom bodies memory traces? Studies on biochemical learning mutants

1987 • 42 citations

Work in Invertebrates on the Mechanisms Underlying Learning

1984 • 42 citations

Plasmids encoding PKI(1–31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells

1989 • 42 citations

Assay of cyclic nucleotide-dependent protein kinases.

1979 • 38 citations

cAMP-dependent Protein Kinase: A Framework for a Diverse Family of Enzymes

1988 • 31 citations

Shear Stability of drag-reducing Polyacrylic Acid Solutions

1973 • 16 citations

Versatile plasmid vectors for the construction, analysis and heat-inducible expression of hybrid genes in eukaryotic cells

1988 • 14 citations

A microtiter-based assay for protein kinase activity suitable for the analysis of large numbers of samples, and its application to the study of Drosophila learning mutants

1988 • 9 citations