Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Characteristics of a Serially Transplanted Mouse Mammary Tumor and Its Tissue-Culture-Adapted Derivative

1972 • 411 citations

Radiation response of multicell spheroids--an in vitro tumour model.

1976 • 236 citations

Proliferation and viability in cellular spheroids of human origin.

1978 • 106 citations

Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea

1977 • 65 citations

Tissue dispersion, cell harvest and fluid suspension culture by the use of bacterial neutral protease.

1975 • 58 citations

In vitro analysis of the response of multicellular tumor spheroids exposed to chemotherapeutic agents in vitro or in vivo.

1978 • 37 citations

CHANGES IN CELL PROLIFERATION KINETICS OCCURRING DURING THE LIFE HISTORY OF MONOLAYER CULTURES OF A MOUSE TUMOUR CELL LINE

1975 • 30 citations

Timing of assays: An important consideration in the determination of clonogenic cell survival both in vitro and in vivo

1979 • 24 citations

Experimental chemotherapy studies: intercomparison of assays.

1980 • 22 citations

Flow cytometric analysis of adriamycin-perturbed mouse mammary tumors.

1979 • 22 citations

Single-agent chemotherapy of a solid murine tumor assayed by growth delay and cell survival.

1980 • 22 citations

Drug or radiation changes to the host which could affect the outcome of combined modality therapy

1979 • 20 citations

Use of a bacterial neutral protease for disaggregation of mouse tumours and multicellular tumour spheroids

1980 • 19 citations