Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Role of angiogenesis in tumor growth and metastasis

2002 • 2,310 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Specialization of tumour vasculature

2002 • 698 citations

Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

1999 • 638 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Phase I Clinical and Pharmacokinetic Study of Bcl-2 Antisense Oligonucleotide Therapy in Patients With Non-Hodgkin’s Lymphoma

2000 • 460 citations

In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse

2000 • 323 citations

The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors

1997 • 304 citations

Molecular angiogenesis

1999 • 228 citations

Angiogenesis modulation in cancer research: novel clinical approaches

2002 • 181 citations

Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins

2001 • 150 citations

Bcl‐2 overexpression enhances the metastatic potential of a human breast cancer line

1997 • 142 citations

Endothelin-1 Protects Ovarian Carcinoma Cells against Paclitaxel-Induced Apoptosis: Requirement for Akt Activation

2002 • 136 citations

Bcl‐2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF‐1mediated transcriptional activity

2002 • 125 citations

Bcl‐2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression andin vivoangiogenesis in a breast carcinoma line

2000 • 123 citations

Angiogenic Potential of Prostate Carcinoma Cells Overexpressing bcl-2

2001 • 101 citations

Current Targets for Anticancer Drug Discovery

2003 • 87 citations

Bcl-2 and bcl-xL Antisense Oligonucleotides Induce Apoptosis in Melanoma Cells of Different Clinical Stages

2002 • 82 citations

Bcl-2/bcl-xL Bispecific Antisense Treatment Sensitizes Breast Carcinoma Cells to Doxorubicin, Paclitaxel and Cyclophosphamide

2002 • 80 citations

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

1996 • 60 citations

Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti‐apoptotic potential under reoxygenation

2001 • 50 citations

Hypoxia upregulates Bcl‐2 expression and suppresses interferon‐γ induced antiangiogenic activity in human tumor derived endothelial cells

2002 • 35 citations

bcl-2 inhibits mitochondrial metabolism and lonidamine-induced apoptosis in adriamycin-resistant mcf7 cells

1999 • 34 citations

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used

2002 • 34 citations

Bcl‐2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity

2001 • 15 citations

Analysis of ribosyl-modified, mixed backbone analogs of a bcl-2/bcl-xL antisense oligonucleotide

2002 • 14 citations

Untitled

2002 • 9 citations

High-dose chemotherapy in breast cancer: Where are we now?

2002 • 8 citations

Targeted drugs take centre stage at US cancer meeting

2001 • 4 citations